Insights & Discussion
There is a significant effect of Chinese herbal medicine for improving Expanded Disability Status Score, annual relapse frequency and the total clinical efficacy rate for multiple sclerosis compared with western conventional treatment.
A total of 1,100 participants were included in the 20 studies from 2004 to 2015. The number of risk of bias which met the criteria varied from 5/12 to 7/12. The top 5 most frequently used herbs are ordinally Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, and Bombyx Batryticatus.
In analysis of annual relapse rate and annual relapse interval, there was a significant difference between CHMs and western conventional treatment. Adverse effects were monitored in 6 studies, and were well tolerated in all MS patients.
The available evidence from present study supported but limited to recommend the routine use of CHM adjuvant therapy for MS because of the poor methodological quality and clinical heterogeneity. However, we identified an area that is worthy of further study.
Discover Related Insights
Magnesium, essential for harmonising nerve signals and preserving the blood-brain barrier, may be linked to neurodegenerative disorders when its balance is disrupted.
2022 International Journal of Molecular Sciences Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration Maier JAM, Locatelli L, Fedele G, Cazzaniga A, Mazur A
Review Article Alzheimer's Disease Magnesium Multiple Sclerosis
The researchers performed a narrative review, beginning with a quick overview of the role of magnesium in the brain. Magnesium is crucial for healthy nerve signal transmission and the upkeep of the blood-brain barrier, which protects the brain from harmful substances in the blood. Then, they discussed evidence suggesting a connection between disrupted magnesium balance and a variety of neurodegenerative disorders.
In the discussion of the results, it was posited that a deficiency in magnesium might contribute to low-grade systemic inflammation, which is common in many illnesses. Specifically, they argued that such inflammation in the brain is a characteristic feature of neurodegenerative diseases. The review found evidence that disruptions in the body's magnesium balance could be associated with multiple sclerosis, Alzheimer's, and Parkinson's diseases.
Acupuncture, when used as an integrative therapy in conjunction with traditional treatments, significantly improves the quality of life in patients with Multiple Sclerosis.
2022 Multiple Sclerosis and Related Disorders Acupuncture for multiple sclerosis: A literature review Khodaie F, Abbasi N, Kazemi Motlagh AH, Zhao B, Naser Moghadasi A
Review Article Acupuncture Multiple Sclerosis
In the methodology of this study, the PUBMED database was meticulously searched in September 2021, for English articles or at least ones with English abstracts, surfacing every article published from the inception of the literature up until the latter part of 2021. The search terms included keywords such as 'acupuncture', 'electroacupuncture', and 'multiple sclerosis' in the titles and abstracts. Out of the 75 articles discovered, just a little over a third, precisely 31 articles, were incorporated into this study.
The discovery from the methodology outlined was that acupuncture provides an array of benefits for Multiple Sclerosis patients. These benefits are primarily seen in the regulation of the neuro-immune system, enhancement of life quality, fatigue reduction, improved bladder functionality, diminished limb spasm and pain, deceleration of disease progression, and decreased relapses. Traditional Chinese acupuncture and scalp acupuncture were observed to be particularly helpful in alleviating Multiple Sclerosis symptoms such as fatigue, neural functional deficits, pain, gait abnormalities, and bladder dysfunction, alongside reducing relapse occurrences. This makes acupuncture a viable integrated therapy option for patients with Multiple Sclerosis.
Acupuncture shows promising results in managing autoimmune diseases by potentially regulating immune responses.
2022 The American Journal of Chinese Medicine Therapeutic Effect and Mechanism of Acupuncture in Autoimmune Diseases Jing Wang, Fangyi Zhu, Wei Huang, Zhengyi Chen, Ping Zhao, Yanting Lei, et al.
Review Article Inflammatory Bowel Disease Multiple Sclerosis Rheumatoid Arthritis
The methodology of the study involved a comprehensive review of how acupuncture, a form of traditional Chinese medicine, may be employed as a treatment method for autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. The research was based on existing knowledge and accumulating data, investigating the role of acupuncture in regulating immune responses during these conditions.
The discussion of the results revealed that acupuncture showed promise in managing these diseases. It was noted that the positive outcomes observed might be linked to the potential of acupuncture to regulate abnormal immune responses which are characteristic of autoimmune diseases. Despite the fact that the precise mechanism through which this achieved is not fully understood, the findings indicate a promising alternative method of managing autoimmune conditions.
Green tea's catechins demonstrate therapeutic effects against neurodegenerative diseases via anti-inflammatory, antioxidant actions, and activating diverse brain cellular pathways.
2022 Molecules Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits Afzal O, Dalhat MH, Altamimi ASA, Rasool R, Alzarea SI, Almalki WH, et al.
Review Article Alzheimer's Disease Cognitive Function Green Tea
The research primarily evaluates the effect of polyphenolic compounds found in green tea, known as catechins, on neurodegenerative diseases. By conducting several interventional and observational studies on humans, the research explores the anti-cancer, anti-obesity, antidiabetic, anti-inflammatory, and neuroprotective properties of these compounds. The biological, pharmacological, antioxidant, and metal chelating abilities of catechins, particularly their influence on different cellular pathways within the brain, are intensively studied.
The results elucidate that catechins exhibit multiple neuroprotective effects. Their anti-inflammatory and antioxidant properties help to inhibit excessive production of cytokines, and inflammatory pathways, while also controlling metal ions and free radicals. Researchers have further established that catechins may curb the phosphorylation of the tau protein and aggregation of amyloid beta, both key markers in neurodegenerative diseases. Additionally, these compounds show potential in reducing alpha-synuclein levels and augmenting dopamine levels. Hence, they significantly contribute to the prevention and treatment of neurodegenerative diseases, including Alzheimer's, Parkinson's, multiple sclerosis, and cognitive deficits.
Traditional Chinese herbal medicine shows promising efficacy in improving clinical symptoms and reducing recurrence of multiple sclerosis.
2021 Frontiers in Neurology Current Utilization and Research Status of Traditional East Asian Herbal Medicine Treatment for Multiple Sclerosis: A Scoping Review Seo Y, Jin C, Cho S-Y, Park S-U, Jung W-S, Moon S-K, et al.
Systematic Review Multiple Sclerosis
In the methodological process for this research, a scoping review was conducted using the Arksey and O'Malley framework, focusing on studies related to the use of herbal medicine treatments for MS patients. The researchers carried out the investigation in March 2020, by reviewing articles published until 2019 found in six databases which include PubMed, Embase, Cochrane, KoreaMed, NDSL, and OASIS.
In the findings, 14 studies were identified out of the 1,445 articles and were analysed in line with the study's questions. Predominantly, these were single and serial case reports, with the majority of the studies being conducted in China. It was noted that a total of 20 prescriptions which contained 95 types of herbs were used in intervention and observational studies. The results of the research revealed that herbal medicines were successful in improving clinical symptoms of MS and reducing recurrence rates, with oxidative stress identified as the main presumed cause of MS.
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