Existing trials show a positive impact of Xuefu Zhuyu decoction (XZD), a traditional herbal formula that treats primary dysmenorrhea.

2019 Medicine Herbal medicine (Hyeolbuchukeo-tang or Xuefu Zhuyu decoction) for treating primary dysmenorrhea Leem J, Jo J, Kwon CY, Lee H, Park KS, Lee JM

Systematic Review Xue Fu Zhu Yu Tang

The study conducted a systematic review and meta-analysis to evaluate the effectiveness of Xuefu Zhuyu decoction (XZD), a traditional herbal formula, in treating primary dysmenorrhea. Out of 475 initially screened studies, 8 randomized controlled trials (RCTs) involving 1048 patients were included. XZD, either alone or combined with western medication (WM), showed promise in relieving pain associated with primary dysmenorrhea compared to WM alone. However, the evidence is limited due to the risk of bias in the included trials, methodological flaws, and small sample sizes. Further high-quality, large-scale RCTs are needed to establish the role of XZD in managing primary dysmenorrhea effectively. The potential mechanisms of XZD's effects on dysmenorrhea involve anti-inflammatory activity, improved blood circulation, and antinociceptive effects.

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