Insights & Discussion
Chinese herbal medicines or their components can potentially delay aging by regulating aging-related genes via different signaling pathways.
The methodology for this paper involved conducting a systematic literature review of studies published in the past five years. The databases used for this purpose included PubMed, EMBASE, Scopus, and Web of Science. Out of a total of 2485 papers initially located, 212 were selectively screened based on the elimination of duplicate entries and their title relevance. The final selection comprised 23 studies suitable for the review. Among these studies, 13 utilized mice as the animal model, while 10 employed alternative animal models or cell lines.
The results showed that Chinese herbal medicine and their active components play a significant role in combating aging. This is achieved through the regulation of genes associated with aging via various signaling pathways. This leads to the conclusion that there is significant potential for the development of Chinese herbal medicines as antiaging drugs, or for their utilization within the medical cosmetology industry.
Discover Related Insights
Regular nut consumption, particularly peanuts and walnuts, is associated with a lower incidence of frailty in aging female populations.
2023 The Journal of Nutrition Long-Term Consumption of Nuts (Including Peanuts, Peanut Butter, Walnuts, and Other Nuts) in Relation to Risk of Frailty in Older Women: Evidence from a Cohort Study Wang R, Hannan MT, Wang M, Schwartz AW, Lopez-Garcia E, Grodstein F
Cohort Study Anti-Ageing Frailty Walnut
The methodology of the study includes a population-based observational study of nonfrail women aged 60 and above from 11 states across the US, from the Nurses' Health Study. The outcome focused on incidence of frailty, defined through the FRAIL components such as fatigue, lower strength, reduced aerobic capacity, multiple chronic conditions, and significant weight loss. These were assessed every four years from 1992 to 2016. Food Frequency Questionnaires were used to examine the intake of peanuts, peanut butter, walnuts, and other nuts every four years from 1990 to 2014. Total nut consumption was calculated and categorized into varying serving sizes, and the relation of intake of each type of nut with frailty was examined separately using Cox proportional hazard models, adjusted for various factors such as age, smoking, BMI, diet quality, and medication use.
In discussing the results, out of 71,704 participants, 14,195 frailty cases arose over a million person-years. Notably, regular consumption of nuts, particularly peanuts and walnuts, showed a significant inverse relation with frailty. That is, a higher intake of these types of nuts were associated with lower cases of frailty. However, the same didn't apply to peanut butter. This affirms the potential benefits of regular nut consumption in aging female population's health and well-being.
Chinese herbal medicines (CHMs) possess multiple advantages, including multiple targets, pathways, and low toxicity, for the treatment of prostate cancer.
2023 Chinese Herbal Medicines Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice Kong F, Wang C, Zhang J, Wang X, Sun B, Xiao X, et al.
Review Article Prostate Cancer
The research team undertook an in-depth review of experimental research and clinical practices related to the use of CHMs for prostate cancer treatment, with the data being sourced from PubMed, Embase, and Web of Science. The focus of the review was on recent studies published within the last five years. The research identified five CHM formulas and six single CHM extracts, along with 12 CHM-derived compounds.
The research findings demonstrated that CHMs induced apoptosis, autophagy, and cell cycle arrest in prostate cancer cells, and concurrently suppressed angiogenesis, proliferation, and cell migration. The CHMs also displayed efficacy in overturning drug resistance and in enhancing anti-tumor immunity. The modes of action were identified as the phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin, androgen receptor, epidermal growth factor receptor, and Wnt/beta-catenin signaling pathways which are known to play key roles in the development of prostate cancer. Additionally, the researchers discussed the benefits of CHMs in treating hormone-sensitive and castration-resistant prostate cancer.
Chinese herbal medicine has shown effectiveness in treating amenorrhea caused by antipsychotic drugs, with an overall treatment effectiveness rate of 0.91, but the duration of treatment is relatively long, and further research is required to explore its application in this context.
2022 Journal of Ethnopharmacology Traditional Chinese herbal medicine in treating amenorrhea caused by antipsychotic drugs: Meta-analysis and systematic review Liu L, Li H, Tan G, Ma Z
Systematic Review Antipsychotic
The passage presents a meta-analysis of traditional Chinese herbal medicine for treating amenorrhea caused by antipsychotic drugs. Chinese herbal medicine was found to be effective, with an overall success rate of 0.91, but the treatment duration was often lengthy, exceeding three months. Commonly used herbal remedies included Danggui, Chuanxiong, Taoren, Honghua, Gancao, Fuling, Baizhu, Xiangfu, Chaihu, Shudihuang, and Baishao. The study suggests that Chinese herbal medicine can be a viable option for managing this condition, but further research is needed to understand its mechanisms and optimize treatment approaches.
Chinese Herbal Medicines may help with chronic sinusitis and acute rhinosinusitis symptoms with LDXGT and modified CEZS working well, especially for CRS.
2022 PLOS One Chinese herbal therapy in the management of rhinosinusitis—A systematic review and meta-analysis Cui J, Lin W, May BH, Luo Q, Worsnop C, Zhang AL, et al.
Systematic Review Rhinosinusitis
The review assessed the effectiveness of Chinese herbal medicines (CHMs) in treating chronic rhinosinusitis (CRS) and acute rhinosinusitis (ARS). It found that certain CHMs showed potential in improving CRS symptoms and measures related to sinus health, with the best evidence for LDXGT and modified CEZS formulas. However, more blinded randomized controlled trials are needed to confirm these findings.
Chinese herbal medicine can significantly reduce the risks of complications and need for surgery associated with benign prostatic hyperplasia.
2022 International Journal of Urology Effects of Chinese herbal medicine in patients with benign prostatic hyperplasia: A nationwide cohort study in Taiwan Ou SC, Huang ST, Lin MC, Chen WC, Huang CP, Lin HJ
Cohort Study Benign Prostatic Hyperplasia Dan Shen Ji Sheng Shen Qi Wan
The methodology of the retrospective cohort study involved analyzing data from Taiwan's National Health Insurance Research Database, covering the period between 2001 to 2013. 4142 patients newly diagnosed as having benign prostatic hyperplasia were divided into Chinese herbal medicine users and non-users. To compare these groups, they employed 1:1 propensity score matching, and the risk of complications related to benign prostatic hyperplasia was evaluated using the Cox proportional hazard model.
The results showed that during the study period, the risk of complications related to benign prostatic hyperplasia was considerably lower in the Chinese herbal medicine group compared to the non-Chinese herbal medicine group, even when other variables were controlled for. The Chinese herbal medicine users had a significantly lower risk of urinary tract infection and urine retention. Plus, the Chinese herbal medicine users experienced a lower incidence rate of surgery related to benign prostatic hyperplasia and enjoyed a longer surgery-free interval than non-Chinese herbal medicine users. Among the Chinese herbal medicine, Salviae miltiorrhizae and Ji-Sheng-Shen-Qi-Wan were prescribed the most by traditional Chinese medicine practitioners.
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