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Wen Dan Tang potentially treats neurological, psychiatric disorders, cardiovascular diseases, and digestive disorders, and might improve life quality in headache patients.
2022 Medicines Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders? Pradhan SK, Li Y, Gantenbein AR, Angst F, Lehmann S, Shaban H
Systematic Review Wen Dan Tang
The methodology of the study included the utilization of various online databases like PubMed, Medline, Cochrane Library, AcuTrials, Embase, Semantic Scholar, Jstor, and internet research. The study also involved reviewing ancient and modern Chinese medical textbooks.
The research noted that while there were no dedicated studies on Wen Dan Tang in the context of migraine and tension-type headaches, it gathered and examined data for each compound found in the formula.
The discussion of the results revealed the therapeutic potential of the bioactive compounds present in Wen Dan Tang. This was especially in the case of patients with neurological and psychiatric disorders, cardiovascular diseases, metabolic syndrome, and digestive disorders. Additionally, the correlations between Wen Dan Tang and the reduction of headaches were explored. A potential improvement in the quality of life was highlighted, especially for patients suffering from migraines and tension-type headaches.
Evidence indicates that acupuncture treatment may be of benefit in several neuropsychiatric disorders, including depression, anxiety, schizophrenia, and Alzheimer's Disease.
2019 Frontiers in Psychiatry The Effects of Acupuncture on Glutamatergic Neurotransmission in Depression, Anxiety, Schizophrenia, and Alzheimer's Disease: A Review of the Literature Tu CH, MacDonald I, Chen YH
Review Article Alzheimer's Disease Anxiety Depression
The pathophysiology of these disorders may be associated with glutamate dysregulation, marked by a high rate of glutamate release and elevated expression of glutamate receptors and glutamate transporters in the CNS. The ability of acupuncture stimulation to modulate glutamate receptor and EAAT expression suggests that the treatment effects of acupuncture are underpinned by its intervention in the dysregulated glutamate system. Further preclinical and clinical studies are needed to clarify the possible mechanisms of acupuncture in these neuropsychiatric disorders and to establish protocols for treatment guidelines.
Serotonin function, influenced by vitamin D and omega-3 fatty acids, plays a critical role in neuropsychiatric disorders and certain behavioral functions.
2015 The FASEB Journal Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior Patrick RP, Ames BN
Review Article ADHD Bipolar Disorder Impulsive Behaviour
The paper synthesizes prior research into serotonin's role in managing various brain functions and behaviours, and how its dysfunction is commonly seen in conditions like attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior. The researchers then put forward potential mechanisms showing the influence of vitamin D and the marine omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, on serotonin synthesis, release, and function in the brain. Serotonin in the brain is synthesized from tryptophan by tryptophan hydroxylase 2, a process that is activated by a vitamin D hormone.
Possible mechanisms proposed include eicosapentaenoic acid increasing serotonin release from presynaptic neurons by lowering E2 series prostaglandins, and docosahexaenoic acid affecting serotonin receptor action by increasing cell membrane fluidity in postsynaptic neurons. The study posits that suboptimal levels of vitamin D and omega-3 fatty acids, in combination with genetic factors at key developmental stages, could lead to dysfunctional serotonin activation and function – a possible underlying mechanism behind neuropsychiatric disorders and depression. The paper suggests that optimizing vitamin D and marine omega-3 fatty acid intake could potentially curtail and modulate the severity of brain dysfunction.