The Gui Zhi-Shao Yao herb pair in traditional Chinese medicine potentially treats chronic pain, anxiety, and depression through interactions with nine key targets.
Network Pharmacology Anxiety Depression Shao Yao
The methodology in this research utilised network pharmacology to explore the active components of the "Gui Zhi-Shao Yao" herb pair and their possible targets. Initially, 15 active compounds were identified through a series of analysis which revealed about 130 potential targets. By considering the intersections between the targets of the "Gui Zhi-Shao Yao" herb pair and chronic pain, anxiety disorder, and mental depression, nine vital targets were identified and listed in order of importance.
The results discussion revealed that the "Gui Zhi-Shao Yao" herb pairing acted on the nine identified key targets to alleviate chronic pain, anxiety, and depression. Gene ontology and pathway analysis demonstrated that there were 11 primary pathways, including AGE-RAGE signalling pathway, IL-17 signalling pathway, and TNF signalling pathway. These pathways appear to be actively involved in the pathological processes, providing a holistic understanding of how the "Gui Zhi-Shao Yao" herb pair functions therapeutically.
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