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Consuming “Sneznik-1/79” mineral water significantly improves intestinal health and reduces cholesterol in type 2 diabetes patients.
2023 Heliyon The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus Jovicic N, Andjic M, Novakovic J, Jeremic N, Zivkovic V, Srejovic I, et al.
Cohort Study Gut Microbiota Intestinal Peristalsis Mineral Water
The study involved 60 patients with confirmed Type 2 Diabetes, who drank “Sneznik-1/79” mineral water from Serbia daily for 28 days. Researchers conducted standard biochemical tests, including glucose level, lipid profile, and stool analysis. Additionally, blood samples were taken to assess the impact of the water on oxidative stress markers.
Post consumption of “Sneznik-1/79” water, a substantial decrease in total cholesterol levels was noted. Notably, all patients experienced regular daily bowel movements, indicating improved intestinal peristalsis. Half of the participants showed elimination of dysbiosis. Furthermore, there was an increase in antioxidants like superoxide dismutase and reduced glutathione, suggesting enhanced antioxidant capacity. The study highlights “Sneznik-1/79” water as a potential complementary treatment for improving gut health and reducing cholesterol in Type 2 Diabetes patients.
Berry fruits such as blueberries, cranberries, raspberries, and strawberries could potentially improve gut microbiota and reverse dysbiosis in chronic kidney disease patients.
2023 Nutrition Reviews Blueberry, cranberry, raspberry, and strawberry as modulators of the gut microbiota: target for treatment of gut dysbiosis in chronic kidney disease? From current evidence to future possibilities Coutinho-Wolino KS, Melo MFS, Mota JC, Mafra D, Guimarães JT, Stockler-Pinto MB
Review Article Chronic Kidney Disease Cranberry Gut Microbiota
Methodology: This research explores the therapeutic potential of berry fruits, including blueberries, cranberries, raspberries, and strawberries, in relation to modulating gut microbiota in chronic kidney disease (CKD) patients. The fruit’s rich polyphenol and nutrient content are assumed to promote the selective growth of beneficial bacteria, thus improving the clinical status of these patients. The study scrutinizes the impact on the abundance of mucus-producing bacteria and short-chain fatty acids specifically.
Discussion of Results: The gathered evidence illustrates that berry fruits, particularly with a daily intake of 5 mg, can promote diversity in the gut microbiota and possibly reverse dysbiosis, a common issue in chronic kidney disease patients. These fruits are found to increase the expression of mRNA involved in gut tight junctions such as occludin, TJP1, and mucin, and they may reduce uremic toxins by controlling the gut microbiota, improving the uremic condition. As such, long-term use of berry fruits could be an effective strategy for CKD patients.
Goji berry leaves have stronger anti-colitis effects than mulberry leaves, ameliorating tissue damage and better regulating inflammatory responses and gut microbiota.
2023 Food & Function Goji berry leaf exerts a comparable effect against colitis and microbiota dysbiosis to its fruit in dextran-sulfate-sodium-treated mice Yu C, Chen Y, Ahmadi S, Wu D, Wu J, Ding T, et al.
Experimental Study Anti-Colitis Anti-Inflammatory Colitis
The research entailed a comparative study conducted on goji berry and mulberry leaves versus their respective fruits. To determine their anti-colitis effects, the experiment was administered to C57BL/6N mice that had been induced with colitis through dextran-sulfate-sodium. Through the utilization of measures such as ELISA and western blotting analysis, researchers were able to observe how each leaf versus its corresponding fruit ameliorated colitic symptoms, tissue damage, and was able to influence the overproduction of certain pro-inflammatory cytokines.
The results showed that both the goji berry leaf and fruit significantly reduced symptoms of colitis and improved tissue damage while the mulberry leaf did not show similar improvements. The goji berry leaf exhibited the strongest performance in restraining the overproduction of pro-inflammatory cytokines and further repairing the damaged colonic barrier. It also effectively adjusted gut microbiota equilibrium by increasing beneficial bacteria and decreasing harmful ones. The berries and leaves similarly restored certain dietary fibers to alleviate inflammation, but the mulberry leaf did not achieve this for butyrate. This is the first report to provide a comprehensive contrast of anti-colitis effects between the leaves and fruits of goji and mulberry.
Changes in gut microbiome associated with a low-fat, vegan diet and cooked soybeans may reduce the frequency and severity of postmenopausal hot flashes.
2023 Complementary Therapies in Medicine A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome. An exploratory analysis Kahleova H, Holtz DN, Strom N, La Reau A, Kolipaka S, Schmidt N, et al.
Randomised Controlled Trial Gut Microbiota Hot Flushes Low Fat Diet
In this study, 84 postmenopausal women experiencing two or more moderate-to-severe hot flashes daily were randomly assigned to a low-fat, vegan diet with daily cooked soybeans or allowed to maintain their usual diet. Over a 12-week period, the frequency and severity of hot flashes were tracked using a mobile application. In 11 women from the group, gut microbiome was analyzed at the start and after 12 weeks of the dietary intervention, using deep shotgun metagenomic sequencing.
The women who underwent gut microbiome testing experienced a substantial decrease in total hot flashes during the dietary intervention, and severe hot flashes disappeared entirely in this group. Alpha and beta diversity within the microbiome showed no significant difference in the intervention group between baseline and the end of the 12 weeks. Interestingly, adjustments in the relative abundance of certain bacterial strains, notably Porphyromonas and Prevotella corporis, were linked with the reduction in severe day hot flashes, while changes in the relative abundance of Clostridium asparagiforme were associated with a reduction in total severe hot flashes and severe night hot flashes.
Long-term intake of traditionally made Doenjang, particularly high in certain species, may improve symptoms of estrogen deficiency more effectively than unfermented soybeans.
2023 Foods Improvement of Estrogen Deficiency Symptoms by the Intake of Long-Term Fermented Soybeans (Doenjang) Rich in Bacillus Species through Modulating Gut Microbiota in Estrogen-Deficient Rats Zhang T, Yue Y, Jeong SJ, Ryu MS, Wu X, Yang HJ, et al.
Animal Study Bacillus Gut Microbiota Menopause
The study involved using four different types of traditionally made Doenjang (TMD), distinguished based on the quantities of certain species and biogenic amines they contained. These were used to observe possible alterations in energy, glucose, and lipid metabolism in estrogen-deficient female rats via potential modification of the gut microbiota. This involved comparing a control group of rats that underwent ovary removal with five other groups that were supplemented with different types of TMD and cooked soybeans.
The outcomes revealed that weight gain and visceral fat mass were lower and lean body mass was higher in the TMD and cooked soybean intake groups compared to the control group, however, these figures were not as good as those in the normal control group. Additionally, the hepatic triglyceride content was lower with TMD intake. It was further observed that the intestinal health significantly improved in the TMD groups, and some groups revealed more improvements than others. Concerning gut microbiota, certain groups showed an increase in certain types of organisms, suggesting a benefit from high amounts of the specific species in TMD. The study inferred that TMD rich in certain species correlates positively with the regulation of estrogen-related markers.
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