Gui Zhi Decoction and associated formulas significantly improve the effectiveness of allergic rhinitis treatments when used alone or combined with Western medicine.

2021 Evidence-Based Complementary and Alternative Medicine Efficacy and Safety of Guizhi Decoction AssociatedFormulas for Allergic Rhinitis: A Systematic Review Yang S, Fu Q, Deng H, Wu J, Zhang Q, Wang L, et al.

Systematic Review Gui Zhi Gui Zhi Tang Hay Fever

The study aimed to evaluate the efficacy of Guizhi Decoction and associated formulas for treating allergic rhinitis. It included a comprehensive search of seven online databases for studies published until February 23, 2020. Each selected study's quality was assessed using the Cochrane Collaboration risk of bias tool. The research used systematic reviews based on the Cochrane systematic review method, facilitated by RevMan 5.3 Software. Interventions in the study varied from using Guizhi Decoction and associated formulas alone to combining them with Western medicine, acupoint-based therapy, Chinese patent medicine, and placebo control.

Data from 23 trials involving 2281 participants were collected and systematically analysed. The results showed that Guizhi Decoction and associated formulas, either alone or in conjunction with Western medicine or acupoint-based therapies, exhibited higher efficacy compared to Western medicine alone. The study also reported that adding nasal traditional Chinese medicine fumigation therapy to the Guizhi Decoction formulations could further improve treatment effectiveness. Adverse events were primarily mild and primarily associated with the control groups that used Western medicine alone, requiring no specific medical intervention.

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