This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
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Pomegranate, due to its polyphenols, flavonoids and fatty acids, exhibits significant pain-relieving effects and could potentially be used as a treatment for various types of pain.
2020 Plants Pomegranate as a Potential Alternative of Pain Management: A Review Guerrero-Solano JA, Jaramillo-Morales OA, Velázquez-González C, De la O-Arciniega M, Castañeda-Ovando A, Betanzos-Cabrera G, et al.
Review Article Chronic Pain Neuropathic Pain Pomegranate
The methodology utilized in the research consisted of conducting a review of scientific articles that met specific inclusion criteria. They focused on the use of different parts of a pomegranate and how they impact different kinds of pain. Special attention was given to the antinociceptive effect of pomegranate, with the potential mechanisms of action being closely scrutinized.
The results of the review have provided evidence that the pomegranate plant contains elements that have an antinociceptive effect and that this effect could be due to the presence of compounds like polyphenols, flavonoids, and fatty acids. The analyses suggest that these effects might be due to the activation of the L-arginine / NO pathway, TRP superfamily members (TRPA1 or TRPV1) and the opioid system. Implications for the field include understanding the mechanisms by which this effect is generated to potentially develop alternative treatments for specific types of pain, aiming to both alleviate discomfort and reduce the adverse effects produced by traditional drugs. The research proposes that the pomegranate could be further considered for the treatment of inflammatory, nociceptive, and neuropathic pain.