This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
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Pumpkin seeds are recognised for their medicinal, nutritional, and cosmetic benefits, including anti-diabetic, heart disease prevention, anti-cancer, and antioxidant qualities.
2024 The Natural Products Journal Pumpkin Seeds (Cucurbita spp.) as a Nutraceutical Used In Various Lifestyle Disorders Wal A, Singh MR, Gupta A, Rathore S, Rout RR, Wal P
Review Article Anti-Parasite Anticancer Antioxidant
The review article undertakes a comprehensive exploration of the nutraceutical importance of pumpkin seeds. The methodology includes an examination of the various known substances in the seeds, such as phytoestrogens, unsaturated fatty acids, and vitamin E. The study then delves into the different benefits and therapeutic uses of these components stretching from medicinal to nutritional to cosmetic applications.
The results of this research are diverse and impressive, with implications for several major health sectors. Their potential anti-diabetic and hypoglycemic properties could suggest a significant role in the management and prevention of diabetes. Meanwhile, the seeds' potential in cardiovascular disease prevention could help to address one of the most pressing global health issues. Moreover, potential anti-cancer properties imply that these seeds could even have a part to play in cancer prevention. The review also described potential additional qualities, such as antidepressant, anti-helminthic (parasite-removing), and antioxidant effects.
Noni fruit and its compounds demonstrate significant potential in cancer therapy by inducing apoptosis, arresting cell cycle, inhibiting angiogenesis, and modulating immune system.
2024 Phytotherapy Research Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update Kitic D, Miladinovic B, Randjelovic M, Szopa A, Seidel V, Prasher P, et al.
Systematic Review Anticancer Noni
In this study, a systematic review was put forth to scrutinize the therapeutic effectiveness of Morinda citrifolia L., commonly known as Noni, specifically looking into its effects on various forms of cancer. The review employed an extensive search of various scientific databases to gather relevant literature. This included both in vitro and in vivo studies, as well as clinical trials, specifically focusing on the outcomes of Noni fruit and its phytoconstituents - anthraquinones, flavonoids, sugar derivatives, and neolignans - on cancer. A carefully structured keyword and criteria search ensured a robust collection and analysis of data.
The plethora of studies compiled point out to Noni's complex role in cancer therapy, underlining its various bioactive elements and their methods of activity. Significant anticancer and chemopreventive potential of Noni was observed, establishing it as potentially a safe and effective option in cancer prevention and treatment.
Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.
2023 Journal of the Science of Food and Agriculture Carrot and carotene and multiple health outcomes: an umbrella review of the evidence Yi X, Li J, Liao D, Peng G, Zheng X, Xu H, et al.
Review Article Alzheimer's Disease Anticancer Breast Cancer
An umbrella review methodology was adopted to identify connections between carrot and carotene intake and various health outcomes. We turned to databases such as Web of Science, PubMed, and Embase to find the needed data. The analysis included the collected evidence from both interventional and observational studies that focused on carrots, carotene, and any related health impact. To estimate the summary effect size for each correlation, both random and fixed effects models were employed.
The study reviewed a total of 1329 studies and utilized the data from 30 meta-analyses with 26 health outcomes that fit the eligibility requirements. These featured outcomes related to various types of cancer, fractures, age-related cataract, sunburn, and Alzheimer's disease. The associations were analyzed between the health outcomes and the intake of carrots, intake of carotene, and serum carotene levels.
The ethanol extract from adzuki beans significantly reduces lung metastasis and invasion of melanoma cells, showing potential for functional food development.
2023 Bioscience, Biotechnology, and Biochemistry Potential Ability of Hot Water Adzuki (Vigna angularis) Extracts to Inhibit the Adhesion, Invasion, and Metastasis of Murine B16 Melanoma Cells ITOH T, UMEKAWA H, FURUICHI Y
Network Pharmacology Anticancer Lung Metastasis Melanoma
The methodology of the study involved extracting the 40% ethanol eluent from the fraction of hot-water extract from adzuki beans adsorbed onto a type of resin. This extract, dubbed EtEx.40, was then tested on B16-BL6 melanoma cells, examining specifically its effects on adhesion, migration, and invasion into extracellular matrix components and their invasion into reconstituted basement membrane (colloquially referred to as matrigel), while ensuring it did not affect cell proliferation in vitro.
The results illustrated a significant difference in the presence of tumor colonies when treated with EtEx.40. The extract showed a considerable inhibitory effect on the experimental lung metastasis, as well as the invasion of the melanoma cells. Furthermore, the adhesion and migration of the melanoma cells into the extracellular matrix components were also reduced. The results demonstrated a strong antimetastatic role of the ethanol extract of adzuki beans.
Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.
2023 Food Chemistry Advances The whole pomegranate (Punica granatum. L), biological properties and important findings: A review Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, et al.
Review Article Anticancer Antimicrobial Antiviral
In the methodological approach of the study, a comprehensive review was undertaken to collate information on the bioactive components found within pomegranates and their by-products (aril, seed, and peel). The study emphasized the pomegranate peel's properties owing to its high content of the bioactive compounds. The aim was to elucidate the nutritional and functional aspects of pomegranates, particularly as a functional food.
The results outlined that pomegranates, especially their peel, contain bioactive compounds, including punicalagin, punicalin, ellagic acid, punicic acid, and anthocyanins. Therefore, they have potential functional properties such as antimicrobial, anticancer, and antiviral characteristics. These results suggest that pomegranates could be explored to develop nutraceutical or functional food products due to their profound properties. The peel of the pomegranate, specifically, showcases significant potential for development due to its higher bioactive compound content compared to other parts of the fruit.
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