This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
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Acupuncture is a safe and effective treatment for Seasonal Allergic Rhinitis, significantly improving symptoms without needing relief medication or causing side effects.
2022 The American Journal of Chinese Medicine Effect of Acupuncture in the Treatment of Seasonal Allergic Rhinitis: A Randomized Controlled Clinical Trial Xue CC, English R, Zhang JJ, Da Costa C, Li CG
Randomised Controlled Trial Acupuncture
The study was a two-phase, single-blind, crossover clinical trial where randomly assigned subjects, split into two groups, were treated with either real or sham acupuncture. All participants received treatment thrice a week for four weeks straight before being flipped onto the other form of treatment for another four uninterrupted weeks without a washout period. The real acupuncture treatment plan was guided by Chinese Medicine Theory. The subjects' responses were measured at various stages - before, during, and after the trials.
In the study, significant improvement was marked in the subjective symptom scores, both nasal and non-nasal, between the group that received the genuine acupuncture and the sham treatment. It was noteworthy, however, that no marked differences were found in the relief medication scores between the two groups. There were also no recorded side effects from either the real or sham acupuncture groups. This suggests that acupuncture proves to be a safe and effective alternative for managing Seasonal Allergic Rhinitis.
Jia Wei Yu Ping Feng San, a traditional Chinese medicine, alleviates allergic asthma by reducing airway inflammation, mediated by suppressing group 2 innate lymphoid cells.
2021 Frontiers in Pharmacology Jia-Wei-Yu-Ping-Feng-San Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation in Allergic Asthma Xue L, Li C, Ge G, Zhang S, Tian L, Wang Y, et al.
Clinical Study Yu Ping Feng San
In this study, a model of allergic asthma was established by sensitizing and challenging female C57BL/6 mice with Ovalbumin (OVA). Following this, the assessment of airway hyperresponsiveness was done using direct airway resistance analysis. Levels of inflammation were examined in bronchoalveolar lavage fluid (BALF), and lung tissue sections were analyzed through HE and PAS staining, studying mucus hypersecretion and inflammatory cell infiltration. The number and proportion of ILC2s, their related transcription factors (GATA3, IRF4), and type 2 cytokines were also measured from lung tissue samples. Moreover, the ILC2s were extracted from mouse lungs followed by evaluation of ILC2s-related cytokines, and transcription factors GATA3 and IRF4 after IL33-induced activation of ILC2s.
The results showed that JWYPFS treatment significantly mitigated airway resistance and decreased inflammatory cells such as eosinophils in these mice. It also hindered mucus production and type 2 cytokines. Importantly, JWYPFS dramatically decreased the number and proportion of ILC2s, and the mRNA levels of their related transcription factors - GATA3, and IRF4. This research indicates that JWYPFS could be an effective agent in treating allergic asthma by alleviating ILC2s-mediated airway inflammation.
Allergic rhinitis in children, according to traditional Chinese medicine, is interrelated with the functionality of lungs, spleen, and kidney and can be treated with combined Western and Chinese herbal medicines.
2021 Translational Pediatrics Current status of Chinese herbal medicine to treat allergic rhinitis in children: from the perspective of Western medicine—a narrative review Liang J, Gu Q
Review Article
The methodology of this study was based on a review of both traditional Chinese and Western medical theories and practices. Chinese theory postulates that BiQiu, or allergic rhinitis in children, is primarily related to a congenital deficiency in vital qi, dysfunction of the lungs inhibiting nose orifices, and a deficiency of spleen and kidney leading to lung qi deficiency. The review looked into herbal monomers and compounds of Chinese herbal medicines as potential treatments for allergic rhinitis, while also considering the impact of external factors like the cold and inadequate diet.
The review highlighted some of the effects and shortcomings of Chinese herbal medicines used alongside Western medicines for treating allergic rhinitis. Particularly, it focussed on how the unique perceptions of life science of the human body from both Eastern and Western cultures can be brought together for a comprehensive method of treatment. The study also outlined future trends of research to enhance this combined treatment approach.
Gui Zhi Decoction and associated formulas significantly improve the effectiveness of allergic rhinitis treatments when used alone or combined with Western medicine.
2021 Evidence-Based Complementary and Alternative Medicine Efficacy and Safety of Guizhi Decoction AssociatedFormulas for Allergic Rhinitis: A Systematic Review Yang S, Fu Q, Deng H, Wu J, Zhang Q, Wang L, et al.
Systematic Review Gui Zhi Gui Zhi Tang
The study aimed to evaluate the efficacy of Guizhi Decoction and associated formulas for treating allergic rhinitis. It included a comprehensive search of seven online databases for studies published until February 23, 2020. Each selected study's quality was assessed using the Cochrane Collaboration risk of bias tool. The research used systematic reviews based on the Cochrane systematic review method, facilitated by RevMan 5.3 Software. Interventions in the study varied from using Guizhi Decoction and associated formulas alone to combining them with Western medicine, acupoint-based therapy, Chinese patent medicine, and placebo control.
Data from 23 trials involving 2281 participants were collected and systematically analysed. The results showed that Guizhi Decoction and associated formulas, either alone or in conjunction with Western medicine or acupoint-based therapies, exhibited higher efficacy compared to Western medicine alone. The study also reported that adding nasal traditional Chinese medicine fumigation therapy to the Guizhi Decoction formulations could further improve treatment effectiveness. Adverse events were primarily mild and primarily associated with the control groups that used Western medicine alone, requiring no specific medical intervention.
The use of Yu Ping Feng San for pediatric allergic rhinitis appears relatively safe compared to Western medical therapy yet its routine use remains unsupported.
2021 Medicine Yu ping feng san for pediatric allergic rhinitis Liao Y, Zhong J, Liu S, Dai M, Liu Y, Li X, et al.
Systematic Review Children's Health
The study undertakes a systematic search across multiple databases, including PubMed, the Excerpta Medical Database, Cochrane library and more, for randomized controlled trials (RCTs) concerning the use of YPFS for pediatric allergic rhinitis. Extracted results were subjected to stringent bias-risk analysis based on the Cochrane Handbook. A meta-analysis was then implemented using RevMan 5.3 software, and the Grading of Recommendations Assessment, Development and Evaluation methodology was applied to check the quality of evidence for every outcome.
The study pooled 10 RCTs covering 1,069 participants aged between 3-15 years for initial inclusion. After certain exclusions, it was determined from the remaining eight RCTs that the overall efficacy did not show any notable advantage for the test group. In addition, inspections into variation of serum immunoglobulin levels showed no statistical significance. However, the safety of YPFS displayed better results, demonstrating a relatively safer approach with lower recurrence rates compared to Western medical therapy.
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