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Walnut seed skin extract demonstrates potential hepato-renal protective effects, inhibiting inflammatory responses, oxidative stress and apoptosis, in kidney-damaged Sprague-Dawley rats.
2022 Cytokine The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia/reperfusion damage Askin S, Askin H, Dursun E, Palabiyik E, Uguz H, Cakmak , et al.
Animal Study Acute Kidney Injury Acute Renal Ischemia Anti-Inflammatory
In the methodology, Sprague-Dawley rats in acute kidney injury state were divided into three groups: a healthy control, a group induced with renal ischemia/reperfusion (IR), and another group induced with renal IR and treated with walnut seed skin (WSS) extract. Blood, liver and kidney tissues were collected for serum evaluations of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, urea, and creatinine. Histopathological studies were performed on liver and kidney tissues, and gene markers related to anti-oxidant, anti-inflammatory, and apoptotic effects were measured.
The results showed an improvement in deteriorated serum parameters in rats with renal ischemia pre-treated with WSS extract. Histopathological analysis revealed a protective effect of WSS on kidney and liver tissues. Though gene expression studies yielded diverse results for liver and kidney tissues, the consensus was that WSS had a pronounced protective impact on the liver. It was inferred that WSS's healing potential in renal and hepatic tissues seems to work via inhibiting inflammatory response, oxidative stress, and apoptosis.
Shen Ling Bai Zhu San was found to inhibit inflammatory damage in nonalcoholic fatty liver disease, thus offering potential as a preventive and therapeutic treatment.
2021 Journal of Integrative Medicine Hepatic protective effects of Shenling Baizhu powder, a herbal compound, against inflammatory damage via TLR4/NLRP3 signalling pathway in rats with nonalcoholic fatty liver disease Pan M, Zheng C, Deng Y, Tang K, Nie H, Xie J, et al.
Animal Study Hepatoprotective Effects NAFLD Shen Ling Bai Zhu San
In the study, rats were put on a high-fat diet, with or without the addition of Shenling Baizhu powder or probiotics. Assessments were made at week 16, using an echo magnetic resonance imaging analyser to examine body composition, a micro-computed tomography imaging system to measure whole body and liver fat, and a laser perfusion imager to study liver microcirculation. After this, the rats were sacrificed and biochemical markers in the blood as well as liver ultrastructure were evaluated. The expression of proteins associated with liver inflammatory signaling pathways were scrutinized via Western blot analysis alongside a high-throughput screening of 29 relevant inflammatory factors in liver tissue.
The results indicated that supplementing with Shenling Baizhu powder reduced body weight, serum free fatty acid, and insulin resistance. It also improved liver microcirculation and ultrastructural abnormalities. Quantitative analyses manifested that the treatment lowered fat mass and visceral fat. Moreover, the powder reduced the expression of certain inflammatory signaling pathway-related proteins and modified the expression levels of some inflammatory cytokines found in liver tissues. Thus, indicating that Shenling Baizhu powder could inhibit the activation of inflammatory agents and suppress related expressions, making it potentially beneficial for the prevention and treatment of inflammatory damage and associated diseases.
The Chrysanthemum indicum L. plant has been discovered to have multiple pharmacological capabilities including anti-inflammatory, antioxidation, antipathogenic, anticancer, immune regulation, and hepatoprotective effects.
2020 The American Journal of Chinese Medicine Chrysanthemum indicum L.: A Comprehensive Review of its Botany, Phytochemistry and Pharmacology Shao Y, Sun Y, Li D, Chen Y
Review Article Anti-Inflammatory Anticancer Antioxidant
In their study, the researchers undertook an extensive review of Chrysanthemum indicum L., a longstanding staple of traditional Chinese medicine. They examined the botany, phytochemistry, and pharmacology of the plant, integrating historical records relating to traditional medicinal usage with modern scientific analyses.
In the discussion of their findings, they made note of the plant's impressive pharmacological portfolio. More than 190 chemical compounds have been identified within the plant, including flavonoids, terpenoids, phenylpropanoids, and phenolic acids. These contribute to a variety of medical benefits - illustratively, its extracts show anti-inflammatory and anti-oxidation properties, and compounds isolated from the plant suggest potential anticancer, antipathogenic microorganism, immune regulation, and hepatoprotective effects.