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Honeysuckle extract could provoke anaphylaxis and specific ingredients in honeysuckle potentially trigger this reaction.
2021 Chinese Herbal Medicines Anaphylaxis effect and substance basis of honeysuckle extract Feng Y, Qin G, Jing Z, Wang Y, Zhou Y
Network Pharmacology Anaphylaxis Jin Yin Hua
In the methodology, rat peritoneal mast cells were separated and purified, then incubated with a compound, saline, and honeysuckle extract at 37°C for varying time intervals. Cell degranulation was observed under microscopes, and the percentage of Annexin V positive cells, which reflect cell degranulation rate, was detected via flow cytometry. Rats were given honeysuckle extract injections, and afterward, symptoms, histamine, and tryptase levels were analysed to study the anaphylaxis effect.
In the discussion of results, it was discovered that the percentage of Annexin V positive cells and cell degranulation ratio significantly rose in cells treated with honeysuckle extract. Histamine and tryptase levels also increased noticeably after injection of honeysuckle extract. Regression analysis identified certain peaks as potential anaphylactoid ingredients, indicating that honeysuckle could induce anaphylaxis and there were likely specific substances in honeysuckle that caused this reaction.
Honey is more effective than usual care alternatives for improving upper respiratory tract infection symptoms, particularly cough frequency and cough severity.
2020 BMJ Evidence-Based Medicine Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis Abuelgasim H, Albury C, Lee J
Systematic Review Antimicrobial Antimicrobial Resistance Cough
We identified 1345 unique records, and 14 studies were included. Overall risk of bias was moderate. Compared with usual care, honey improved combined symptom score, cough frequency. We combined two studies comparing honey with placebo for relieving combined symptoms.
Honey was superior to usual care for the improvement of symptoms of upper respiratory tract infections. It provides a widely available and cheap alternative to antibiotics. Honey could help efforts to slow the spread of antimicrobial resistance, but further high quality, placebo controlled trials are needed.
Honey can be used as an alternative to antibiotics by clinicians who wish to offer treatment for upper respiratory tract infections, which may help to combat antimicrobial resistance.
2020 BMJ Evidence-Based Medicine Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis Abuelgasim H, Albury C, Lee J
Systematic Review Antimicrobial Antimicrobial Resistance Cough
Upper respiratory tract infections (URTIs) are the most frequent reason for antibiotic prescription. Since the majority of URTIs are viral, antibiotic prescription is both ineffective and inappropriate. However, a lack of effective alternatives, as well as a desire to preserve the patient–doctor relationship, both contribute to antibiotic over prescription. Antibiotic overuse is a key driver of antimicrobial resistance, rated by the UK government as one of the top 10 risks facing Britain. Furthermore, drug resistant infections are associated with worse patient outcomes than antibiotic susceptible infections, underlining the impact of antimicrobial resistance on individual patients.
Moderate‐certainty evidence showed that honey probably reduces cough duration to a greater extent than salbutamol or placebo. Honey group participants were first to get total relief of cough compared to salbutamol or placebo.
2018 Cochrane Database of Systematic Reviews Honey for acute cough in children Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM
Review Article Children's Health Honey URTI
Honey probably relieves cough symptoms to a greater extent than no treatment, diphenhydramine, and placebo, but may make little or no difference compared to dextromethorphan. Honey probably reduces cough duration better than placebo and salbutamol. There was no strong evidence for or against using honey. Most of the children received treatment for one night, which is a limitation to the results of this review. There was no difference in occurrence of adverse events between the honey and control arms.
Honey, in general, and particularly manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.
2014 Archives of Medical Research Anti-influenza Viral Effects of Honey In Vitro: Potent High Activity of Manuka Honey Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N
Network Pharmacology Antiviral Honey Influenza
Antiviral activities of honey samples were evaluated using MDCK cells. To elucidate the possible mechanism of action of honey, plaque inhibition assays were used. Synergistic effects of honey with known anti-influenza virus drugs such as zanamivir or oseltamivir were tested.
Manuka honey efficiently inhibited influenza virus replication (IC50 = 3.6 ± 1.2 mg/mL; CC50 = 82.3 ± 2.2 mg/mL; selective index = 22.9), which is related to its virucidal effects. In the presence of 3.13 mg/mL manuka honey, the IC50 of zanamivir or oseltamivir was reduced to nearly 1/1000th of their single use.
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