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Simultaneous administration of vitamin D and Epigallocatechin gallate significantly reduces the size of uterine fibroids in premenopausal women, and decreases menstrual flow duration.
In this study, 16 premenopausal women with uterine fibroids of varying sizes aged over 40 years old were given doses of Epigallocatechin gallate, Vitamin B6 and Vitamin D daily for 90 days. The women were selected based on specific criteria including their fibroid size and lack of other causes for abnormal uterine bleeding. Each woman kept a detailed daily diary recording details about their bleeding and pelvic pain.
The analysis of the data revealed that there was a noteworthy decrease in both the average size of fibroids for each woman and the size of individual fibroids. This effect was especially pronounced in women with predominantly intramural fibroids in comparison to subserosal fibroids. While menstrual cycle duration and intensity did not change, the length of menstrual flow was decreased. Uterine and ovarian volume as well as endometrial thickness did not exhibit any significant changes. The treatment was generally highly satisfactory to the participants, with no adverse effects reported.
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Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency.
2023 Nutrients Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women Siblini H, Al-Hendy A, Segars J, González F, Taylor HS, Singh B, et al.
Cohort Study EGCG Green Tea Uterine Fibroids
The study involved the pre-testing of a green tea substance known as Epigallocatechin gallate (EGCG) on a cohort of premenopausal women, aged 18 to 40, with and without uterine fibroids, in order to evaluate its safety. The subjects were randomized into three groups, each receiving different treatments. One group took just a daily dose of 800 mg of EGCG, one group combined this EGCG dose with 100 mg of Clomiphene citrate for five days, and the third group combined it with 5 mg of Letrozole for the same period.
The results showed that none of the subjects displayed signs of drug-induced liver injury, and all had normal serum folate levels. Hence, the findings suggest that the daily intake of 800mg of EGCG, whether consumed alone or in combination with Clomiphene citrate or Letrozole for five days, is well-tolerated and not related to any liver toxicity or folate deficiency in women of reproductive age.
Combining Crila with green tea extract (EGCG) has been found to synergistically hinder the growth of human uterine fibroid cells.
2023 F&S Science The combination of natural compounds Crila and epigallocatechin gallate (EGCG) showed enhanced antiproliferative effects on human uterine fibroid cells compared to single treatments. Bai T, Ali M, Somers B, Yang Q, McKinney S, Al-Hendy A
Network Pharmacology Crila EGCG Green Tea
In the methodological process, human uterine leiomyoma (HuLM) cells were treated with varying concentrations of Crila, either alone or combined with epigallocatechin gallate (EGCG), employing various tests. Prominently, assays were performed to examine cell proliferation, with additional analyses conducted to measure protein and gene expressions of proliferation markers.
The interaction of Crila and EGCG resulted in a notable reduction in HuLM cell viability, showing an increased inhibitory effect over singular treatments. This decrease in cell proliferation is attributed to a synergistic efficacy derived from using Crila and EGCG in combination. It was notably characterised by the reduced presence of the proliferation marker, proliferating cell nuclear antigen, both at the messenger RNA and protein levels. It was observed that the process does not induce cell apoptosis, implying that the cell viability reduction is primarily due to decreased cell proliferation.
Recent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.
2022 Melatonin Research Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey Kim TK, Fabisiak A, Brzeminski P, Reiter RJ, Slominski AT
Review Article Honey Melatonin Serotonin
The identification of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey aligns with their presence in insects and plants. Serotonin and melatonin, integral to tryptophan metabolism, serve diverse roles as hormones, neurotransmitters, and antioxidants. Dopamine and tryptamine, essential neurotransmitters, have broad significance across species. The detection of these molecules in honey, a widely consumed health-promoting substance, enhances its beneficial effects on human health.
The findings highlight the multifaceted composition of honey, encompassing compounds with recognized roles in neurotransmission, antioxidant activity, and hormonal regulation. The presence of these molecules not only broadens honey's spectrum of health benefits for humans but also implies their significance in the intricate physiology of social insects, influencing bee development and colony functions. The co-detection of these compounds with vitamin D3 derivatives further underscores the interconnectedness of honey with insect and plant biology, shedding light on potential synergies that contribute to the diverse positive effects of honey on human health.
Vitamin D and Omega 3 fatty acids supplementation appears to reduce the risk of autoimmune diseases.
2022 BMJ Open Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes V, et al.
Cohort Study Autoimmune Disease Omega-3 Fatty Acids Vitamin D
In this nationwide, double-blind, randomized, controlled trial, 25,871 male and female participants over the ages of 50 and 55 respectively, were given either Vitamin D (2000 IU/day), Omega 3 fatty acids (1000 mg/day), both, or a placebo. Over the median follow-up period of 5.3 years, participants self-reported cases of autoimmune diseases, and these were verified by thorough medical record review.
In the discussion of results, it was found that Vitamin D supplementation, regardless of the presence of Omega 3, seemed to reduce the occurrence of autoimmune diseases by 22%. Meanwhile, Omega 3 supplementation alone didn't show a statistically significant reduction in autoimmune diseases, but it did show a larger effect in reducing autoimmune diseases than the reference arm (that received placebo for both Vitamin D and Omega 3).
Green tea extract, specifically epigallocatechin gallate, can inhibit tumor growth and enhance the quality of life in women suffering from uterine fibroids.
2022 International Journal of Health Sciences The use of green tea in the treatment of symptomatic uterine fibroids Badawy A, Shady NW, Maklad SMA, Ait-Allah AS
Randomised Controlled Trial EGCG Green Tea Uterine Fibroids
A total of 75 reproductive-age women with symptomatic uterine fibroids were included in a prospective, randomized control trial. The selection of participants for either group, those receiving 900 mg of green tea extract or those receiving symptomatic treatment, was done via a random, blind method using sealed envelopes. This trial took place over a span of 4 months and the overall study lasted around 3 years.
The results of the study showcased the potency of green tea extract, particularly EGCG, with special regard to its anticancer properties. These manifested as anti-inflammatory, antiproliferative, and antioxidant effects. It was found that the administration of EGCG managed to influence tumor growth pathways, indicating its efficacy in dealing with uterine fibroids. Moreover, another significant progression was observed in the quality of life for the women partaking in this trial. It was confirmed that the use of EGCG could bring about an overall improvement in the living conditions of these women, contributing towards a better, healthier life amidst the struggle with their condition.
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