Insights & Discussion
Simultaneous administration of vitamin D and Epigallocatechin gallate significantly reduces the size of uterine fibroids in premenopausal women, and decreases menstrual flow duration.
In this study, 16 premenopausal women with uterine fibroids of varying sizes aged over 40 years old were given doses of Epigallocatechin gallate, Vitamin B6 and Vitamin D daily for 90 days. The women were selected based on specific criteria including their fibroid size and lack of other causes for abnormal uterine bleeding. Each woman kept a detailed daily diary recording details about their bleeding and pelvic pain.
The analysis of the data revealed that there was a noteworthy decrease in both the average size of fibroids for each woman and the size of individual fibroids. This effect was especially pronounced in women with predominantly intramural fibroids in comparison to subserosal fibroids. While menstrual cycle duration and intensity did not change, the length of menstrual flow was decreased. Uterine and ovarian volume as well as endometrial thickness did not exhibit any significant changes. The treatment was generally highly satisfactory to the participants, with no adverse effects reported.
Discover Related Insights
Recent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.
2022 Melatonin Research Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey Kim TK, Fabisiak A, Brzeminski P, Reiter RJ, Slominski AT
Review Article Honey Melatonin Vitamin D
The identification of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey aligns with their presence in insects and plants. Serotonin and melatonin, integral to tryptophan metabolism, serve diverse roles as hormones, neurotransmitters, and antioxidants. Dopamine and tryptamine, essential neurotransmitters, have broad significance across species. The detection of these molecules in honey, a widely consumed health-promoting substance, enhances its beneficial effects on human health.
The findings highlight the multifaceted composition of honey, encompassing compounds with recognized roles in neurotransmission, antioxidant activity, and hormonal regulation. The presence of these molecules not only broadens honey's spectrum of health benefits for humans but also implies their significance in the intricate physiology of social insects, influencing bee development and colony functions. The co-detection of these compounds with vitamin D3 derivatives further underscores the interconnectedness of honey with insect and plant biology, shedding light on potential synergies that contribute to the diverse positive effects of honey on human health.
Vitamin D and Omega 3 fatty acids supplementation appears to reduce the risk of autoimmune diseases.
2022 BMJ Open Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes V, et al.
Cohort Study Autoimmune Disease Omega-3 Fatty Acids Vitamin D
In this nationwide, double-blind, randomized, controlled trial, 25,871 male and female participants over the ages of 50 and 55 respectively, were given either Vitamin D (2000 IU/day), Omega 3 fatty acids (1000 mg/day), both, or a placebo. Over the median follow-up period of 5.3 years, participants self-reported cases of autoimmune diseases, and these were verified by thorough medical record review.
In the discussion of results, it was found that Vitamin D supplementation, regardless of the presence of Omega 3, seemed to reduce the occurrence of autoimmune diseases by 22%. Meanwhile, Omega 3 supplementation alone didn't show a statistically significant reduction in autoimmune diseases, but it did show a larger effect in reducing autoimmune diseases than the reference arm (that received placebo for both Vitamin D and Omega 3).
We determined the concentration of 20(OH)D3 in honey to be 0.26 µg/g, corresponding to approximately 10 IU/g.
2020 Molecules Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey Kim TK, Atigadda V, Brzeminski P, Fabisiak A, Tang EKY, Tuckey RC, et al.
Experimental Study 20(OH)D3 Honey Vitamin D
Using an LC-MS assay utilizing 20(OH)D3-d3 as internal standard, we determined the concentration of 20(OH)D3 in honey to be 0.26 µg/g, corresponding to approximately 10 IU/g based on the conversion for vitamin D3 (400 IU = 10 µg). While this may seem relatively low, it must be noted that 20(OH)D3, unlike vitamin D3, is an activated form of the vitamin. It is non-calcemic but exerts many of the other activities of 1,25(OH)2D3 seen in cell culture and in animal studies, with comparable potency. Thus, while the amount of 20(OH)D3 in honey is relatively low, it could potentially be of physiological significance.
Honey contains 20(S)-Hydroxyvitamin D3 (20(OH)D3) and its derivatives, including 20(OH)-7DHC, 25(OH)D3, and 1,25(OH)2D3, indicating their production in bees and suggesting potential health implications.
2020 Molecules Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey Kim TK, Atigadda V, Brzeminski P, Fabisiak A, Tang EKY, Tuckey RC, et al.
Experimental Study 20(OH)D3 Honey Vitamin D
This study explores the presence of vitamin D3 derivatives in honey, emphasizing the detection of 20(OH)D3 and related compounds. Analysis using LC-MS revealed distinct peaks corresponding to these derivatives, implying their production in bees during the summer in Alabama.
The identification of 20(OH)D3, 20(OH)-7DHC, 25(OH)D3, and 1,25(OH)2D3 in honey suggests their synthesis within bees, highlighting potential biochemistry and photochemistry processes. This finding opens avenues for understanding the health-related implications of these compounds in honey.
High doses of omega-3 fatty acids, Vitamin D supplementation, and dietary sodium restriction showed significant improvement in reducing rheumatoid arthritis symptoms.
2020 Nutrition Reviews Rheumatoid arthritis and dietary interventions: systematic review of clinical trials Philippou E, Petersson SD, Rodomar C, Nikiphorou E
Systematic Review Omega-3 Fatty Acids Rheumatoid Arthritis Vitamin D
The study method involved conducting a systematic review, with all methods prespecified, in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant articles were found on Medline and Embase. Data were extracted from these articles by two independent reviewers, eventually identifying a total of 70 human studies that fit the scope of the research.
The results indicated that the administration of omega-3 polyunsaturated fatty acids in high doses led to a decrease in rheumatoid arthritis disease activity, as well reduced failure rates of pharmacotherapy. Also, supplementing with Vitamin D and dietary sodium restriction had beneficial effects on some rheumatoid arthritis outcomes. Fasting resulted in significant but brief subjective improvements. Whilst the Mediterranean diet showed improvements in some rheumatoid arthritis disease activity measures, the results from vegetarian, elimination, peptide, or elemental diets implied that the responses are very individualized.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.