Compounds found in green tea, especially EGCG, show significant anti-cancer activity and hold promise as potential anticancer drugs or adjuvants to standard chemotherapy.
Review Article Anticancer Cancer EGCG
The study used a combination of epidemiological and laboratory studies to examine the effects of catechins in green tea on combating cancer. The researchers focused their attention on the four main catechin derivatives found in green tea: epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate—the latter found to be most potent. Attention was given to the quantity of hydroxyl groups and the presence of certain structural groups in these compounds, and how these factors affected antioxidant activity.
The study centered around the effects of catechins on tumor survival, proliferation, invasion, angiogenesis, and metastasis. By doing this, the researchers could observe the influence of the identified compounds on the various processes that lead to the development and spread of cancer. The main point of observation was the capacity of catechins to neutralize reactive oxygen species, a key facet in their anti-cancer activity.
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