This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
Insights & Discussion
The ethanol extract from adzuki beans significantly reduces lung metastasis and invasion of melanoma cells, showing potential for functional food development.
The methodology of the study involved extracting the 40% ethanol eluent from the fraction of hot-water extract from adzuki beans adsorbed onto a type of resin. This extract, dubbed EtEx.40, was then tested on B16-BL6 melanoma cells, examining specifically its effects on adhesion, migration, and invasion into extracellular matrix components and their invasion into reconstituted basement membrane (colloquially referred to as matrigel), while ensuring it did not affect cell proliferation in vitro.
The results illustrated a significant difference in the presence of tumor colonies when treated with EtEx.40. The extract showed a considerable inhibitory effect on the experimental lung metastasis, as well as the invasion of the melanoma cells. Furthermore, the adhesion and migration of the melanoma cells into the extracellular matrix components were also reduced. The results demonstrated a strong antimetastatic role of the ethanol extract of adzuki beans.
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Pumpkin seeds are recognised for their medicinal, nutritional, and cosmetic benefits, including anti-diabetic, heart disease prevention, anti-cancer, and antioxidant qualities.
2024 The Natural Products Journal Pumpkin Seeds (Cucurbita spp.) as a Nutraceutical Used In Various Lifestyle Disorders Wal A, Singh MR, Gupta A, Rathore S, Rout RR, Wal P
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The review article undertakes a comprehensive exploration of the nutraceutical importance of pumpkin seeds. The methodology includes an examination of the various known substances in the seeds, such as phytoestrogens, unsaturated fatty acids, and vitamin E. The study then delves into the different benefits and therapeutic uses of these components stretching from medicinal to nutritional to cosmetic applications.
The results of this research are diverse and impressive, with implications for several major health sectors. Their potential anti-diabetic and hypoglycemic properties could suggest a significant role in the management and prevention of diabetes. Meanwhile, the seeds' potential in cardiovascular disease prevention could help to address one of the most pressing global health issues. Moreover, potential anti-cancer properties imply that these seeds could even have a part to play in cancer prevention. The review also described potential additional qualities, such as antidepressant, anti-helminthic (parasite-removing), and antioxidant effects.
Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.
2023 Journal of the Science of Food and Agriculture Carrot and carotene and multiple health outcomes: an umbrella review of the evidence Yi X, Li J, Liao D, Peng G, Zheng X, Xu H, et al.
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An umbrella review methodology was adopted to identify connections between carrot and carotene intake and various health outcomes. We turned to databases such as Web of Science, PubMed, and Embase to find the needed data. The analysis included the collected evidence from both interventional and observational studies that focused on carrots, carotene, and any related health impact. To estimate the summary effect size for each correlation, both random and fixed effects models were employed.
The study reviewed a total of 1329 studies and utilized the data from 30 meta-analyses with 26 health outcomes that fit the eligibility requirements. These featured outcomes related to various types of cancer, fractures, age-related cataract, sunburn, and Alzheimer's disease. The associations were analyzed between the health outcomes and the intake of carrots, intake of carotene, and serum carotene levels.
Purple carrot roots, rich in bioactive compounds like anthocyanin, may be effective in preventing metabolic syndrome and cancer by reducing inflammation and metabolic changes.
2022 Applied Sciences Delving into the Nutraceutical Benefits of Purple Carrot against Metabolic Syndrome and Cancer: A Review Rasheed H, Shehzad M, Rabail R, Kowalczewski P, Kidoń M, Jeżowski P, et al.
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The methodology employed in the research deeply studies the role of purple carrot’s main bioactive compounds against metabolic syndrome and cancer. The main focus lies on anthocyanin, a phenolic compound present in purple carrot roots. This natural food source was shifted towards as a healthier nutritional approach instead of dietary supplements. The research leans on the effectiveness of these compounds in evading or delaying the onset of cardiovascular diseases, obesity, diabetes, and cancer by inhibiting inflammatory effects.
The discussion primarily surrounds the role of bioactive compounds found in purple carrots, specifically anthocyanin, in their potential prevention of metabolic syndrome and cancer. The study focused on how these components could disrupt the onset of cardiovascular disease, obesity, diabetes, and similar health issues. The results suggest that these compounds were successful in decreasing metabolic changes and inflammation. It has been suggested that purple carrots' inherent components might serve as a major tool in the prevention and treatment of metabolic syndrome and cancer.
Compounds found in green tea, especially EGCG, show significant anti-cancer activity and hold promise as potential anticancer drugs or adjuvants to standard chemotherapy.
2022 International Journal of Molecular Sciences Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer Farhan M
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The study used a combination of epidemiological and laboratory studies to examine the effects of catechins in green tea on combating cancer. The researchers focused their attention on the four main catechin derivatives found in green tea: epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate—the latter found to be most potent. Attention was given to the quantity of hydroxyl groups and the presence of certain structural groups in these compounds, and how these factors affected antioxidant activity.
The study centered around the effects of catechins on tumor survival, proliferation, invasion, angiogenesis, and metastasis. By doing this, the researchers could observe the influence of the identified compounds on the various processes that lead to the development and spread of cancer. The main point of observation was the capacity of catechins to neutralize reactive oxygen species, a key facet in their anti-cancer activity.
The underutilized pomegranate peel, full of abundant bioactive substances, could be repurposed for its potential health benefits like anti-inflammatory, anti-cancer, cardiovascular protection, and antibacterial activities.
2022 Frontiers in Nutrition Pomegranate Peel as a Source of Bioactive Compounds: A Mini Review on Their Physiological Functions Mo Y, Ma J, Gao W, Zhang L, Li J, Li J, et al.
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This paper conducts a miniature review of the characterization and physiological functions of the key bioactive compounds present in pomegranate peel. The exploration underscores the main phenolic compounds in the peel, illustrating substances such as tannins, flavonoids, phenolic acids, dietary fibers, alkaloids, minerals, and vitamins. A deep understanding of these components and their potential benefits is vital to the study and future applications.
The research finds that these core components essentially function as antioxidants, either enhancing oxidative biomarkers or proactively neutralizing reactive oxygen species. By establishing these key functions, it essentially links these activities to a broader context of benefits, including but not limited to anti-inflammatory, anti-cancer, cardiovascular protection, and antibacterial attributes, thereby indicating a potential for substantial health benefits. With comprehensive understanding and appropriate application of these substances, the pomegranate peels, often classified as waste, could find a new life as robust health-enhancing elements.
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