Insights & Discussion
Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.
Vitamin D screening assay is readily available, but the reported lower limit of the normal range is totally inadequate for disease prevention. Based on the epidemiologic studies, ∼75% of all adults worldwide have serum 25(OH)D levels of <30 ng/mL. Because of the recent increase in global awareness, vitamin D supplementation has become a common practice, but Mg deficiency still remains unaddressed. Screening for chronic magnesium deficiency is difficult because a normal serum level may still be associated with moderate to severe deficiency. To date, there is no simple and accurate laboratory test to determine the total body magnesium status in humans.
Discover Related Insights
Magnesium, essential for harmonising nerve signals and preserving the blood-brain barrier, may be linked to neurodegenerative disorders when its balance is disrupted.
2022 International Journal of Molecular Sciences Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration Maier JAM, Locatelli L, Fedele G, Cazzaniga A, Mazur A
Review Article Alzheimer's Disease Magnesium Multiple Sclerosis
The researchers performed a narrative review, beginning with a quick overview of the role of magnesium in the brain. Magnesium is crucial for healthy nerve signal transmission and the upkeep of the blood-brain barrier, which protects the brain from harmful substances in the blood. Then, they discussed evidence suggesting a connection between disrupted magnesium balance and a variety of neurodegenerative disorders.
In the discussion of the results, it was posited that a deficiency in magnesium might contribute to low-grade systemic inflammation, which is common in many illnesses. Specifically, they argued that such inflammation in the brain is a characteristic feature of neurodegenerative diseases. The review found evidence that disruptions in the body's magnesium balance could be associated with multiple sclerosis, Alzheimer's, and Parkinson's diseases.
Alginate, as a treatment option for laryngopharyngeal reflux, is equally effective as proton pump inhibitors and may serve as a potential alternative treatment.
2022 European Archives of Oto-Rhino-Laryngology Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux: a non-inferiority randomized controlled trial Pizzorni N, Ambrogi F, Eplite A, Rama S, Robotti C, Lechien J, et al.
Randomised Controlled Trial Alginate GERD Magnesium
Researchers employed a non-inferiority randomized controlled trial with fifty participants, all of whom exhibited laryngopharyngeal symptoms. They were divided into two treatment groups; one group received the alginate suspension Gastrotuss in three daily doses, while the other was administered Omeprazole once daily. The Reflux Symptom Index and Reflux Finding Score were used to measure the severity of symptoms both before the treatment and after the two-month treatment period.
It was found that both groups had similar Reflux Symptom Index and Reflux Finding Score values initially. After the two-month treatment, both groups demonstrated significant decrease in these indices, suggesting that the symptoms and signs of laryngopharyngeal reflux were significantly reduced, regardless of the treatment given. The difference between the changes in both Reflux Symptom Index and Reflux Finding Score from the two groups was found to be insignificant, thereby indicating that the effectiveness of Alginate is non-inferior to Proton Pump Inhibitors.
Consumption of pumpkin seeds enhances the nutritional status and improves the attention deficit of deaf female children exhibiting ADHD symptoms.
2021 African Journal of Biological Sciences Improvement of attention deficit hyperactive disorder for deaf female children by intake pumpkin seeds Ataya H
Clinical Study ADHD Children's Health Iron
This study investigated 40 deaf female children, aged between 10 and 12 years, who exhibited symptoms of attention-deficit hyperactivity disorder (ADHD). These children were selected from El Amal school for the deaf and divided into two groups; control and experimental. Various data were gathered on personal and socio-economic factors, food habits, diet history, and clinical signs, along with performing the Attention Deficit Disorder Connected with Hyperactivity for Deaf Children test. The experimental group underwent a dietary intervention, consuming 50g of magnesium and iron-rich pumpkin seeds daily over three months.
The results indicated an improvement in both iron and magnesium levels within the experimental group following the dietary intervention. Notably, compared to the control group, the levels of magnesium and iron were significantly higher in the experimental group after introducing pumpkin seeds into their diet. Furthermore, on evaluating the ADHD symptoms via the Attention Deficit Disorder Connected with Hyperactivity for Deaf Children test, the experimental group showed a more substantial improvement after dietary intervention than the control group. Over time, the findings demonstrated the potential beneficial effects of consuming pumpkin seeds on the nutritional status and ADHD symptoms in the studied population.
Magnesium sulfate-rich natural mineral waters are effective and safe as a natural treatment for functional constipation.
2020 Nutrients Magnesium Sulfate-Rich Natural Mineral Waters in the Treatment of Functional Constipation–A Review Dupont C, Hébert G
Review Article Constipation Magnesium
This paper reviews clinical data on the efficacy of magnesium sulfate-rich natural mineral waters in treating functional constipation (FC), a chronic type of constipation with no identifiable physiological, anatomical, or iatrogenic causes. The condition is known to significantly affect patients’ quality of life and increase healthcare costs. The study examines the historical use of magnesium sulfate in treating FC and its longstanding recognition for laxative properties, especially in the context of magnesium sulfate-rich mineral waters.
The review highlights that, despite the long history of using magnesium sulfate-rich mineral waters for their laxative effects, clinical studies specifically demonstrating their effectiveness in FC were scarce before the 21st century. The collected data indicate that these mineral waters are not only effective in treating FC but also safe, positioning them as a viable natural treatment option for this condition.
Magnesium-rich mineral water effectively treats and prevents constipation in children, leading to regular, painless bowel movements.
2020 Russian Journal of Physiotherapy, Balneology and Rehabilitation The use of magnesium-containing mineral waters for functional constipation in children and adolescents Kulikov AG, Zakharova IN, Tvorogova TM, Stepurina LL, Elezova LI
Clinical Study Children's Health Constipation Magnesium
This randomized, prospective, open, comparative study involved 95 children and adolescents aged 10-16 years with functional constipation. They received sanatorium therapy for 18 days, including a sparing-exercise regimen, therapeutic nutrition, health-improving massage, and physiotherapy exercises. Participants were divided into two groups: Group 1 (55 patients) received basic treatment plus magnesium-containing mineral water, while Group 2 (40 patients) received only basic treatment. The study assessed the frequency and nature of defecation, vegetative status, and functional body reserves.
By day 5, 49% of Group 1 patients achieved daily defecation, increasing to 89.1% by the end of treatment. In contrast, only 55% of Group 2 showed positive changes by the end. The mineral water group also had softer, pain-free bowel movements, with most achieving a morning defecation reflex after consuming the water. The control group saw less significant changes in defecation nature, with only 18% reaching softer bowel movements by the end of treatment. The results indicate the effectiveness and safety of magnesium-containing mineral water in treating and preventing functional constipation in children.
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