This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
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Peptic ulcers may be prevented and cured by well-chewed food rich in vegetable fibers and fermented milk products, which increase protective salivary mucus and decrease damaging bile flow.
2024 Psychoneuroendocrinology New approaches to the pathogenesis of peptic ulcer based on the protective action of saliva with special reference to roughage, vegetable fibre and fermented milk products Malhotra SL
Review Article Stomach Ulcer
The research conducted a review of epidemiologic studies focusing on the variations of diet and eating patterns related to the prevalence of peptic ulcer disease across various communities. The effects of dietary patterns were assessed on saliva, gastric juice, and bile. The role of bile was specifically examined in the pathogenesis of peptic ulcer, with the argument that it, rather than hydrochloric acid, played a causal role. The role of saliva in preventing peptic ulcers was emphasized, particularly the protective nature of salivary mucus which is swallowed with food.
The study then suggested the types of diets that can help prevent peptic ulcers, including those rich in roughage, cellulose, vegetable fibers, and fermented milk products such as ghee and yogurt. The research posited this kind of diet can increase the amount of salivary mucus and consequently decrease the flow rate of harmful bile. The study also noted that these insights showed minor changes in diet, and a slower pace of consumption could lead to substantial health benefits.
Moving from dietary composition to eating behaviors, it was suggested that food should be well-masticated to ensure these beneficial digestive processes have an opportunity to occur. At the same time, the research made the case that specific dietary components, particularly short-chain fatty acids like those found in milk products, can retard gall bladder contraction, thereby reducing the amount of bile entering the duodenal lumen. This secondary action further contributes to the potential prevention of peptic ulcers.
Consumption of apple cider vinegar significantly improves certain risk factors for cardiometabolic syndrome, notably fasting blood glucose, glycosylated hemoglobin, and total cholesterol.
2023 Current Medicinal Chemistry The Effects of Apple Cider Vinegar on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Clinical Trials Dadkhah Tehrani S, Keshani M, Rouhani MH, Moallem SA, Bagherniya M, Sahebkar A
Systematic Review Apple Cider Vinegar Blood Sugar Cholesterol
This study applied a systematic review and meta-analysis of clinical trials found in PubMed, Scopus, and ISI Web of Science databases. In this process, trials evaluating the effects of apple cider vinegar consumption on cardiometabolic syndrome risk factors were sought. In total, 25 clinical trials were included in the study, these trials encompassed 1320 adult participants.
The consumed apple cider vinegar led to a general improvement in fasting blood glucose, glycosylated hemoglobin, and total cholesterol. However, for body mass index, insulin resistance, serum insulin, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, no significant results were observed. Conducting a subgroup analysis, the study identified a significant decrease in fasting blood glucose, glycosylated hemoglobin, total cholesterol, and triglycerides in diabetic patients. Further, it was observed that the apple cider vinegar significantly reduced fasting blood glucose levels regardless of the duration of administration and also decreased triglycerides concentration when consumed for 12 weeks or more.
Vincentka natural mineral water reduces gastric damage and improves antioxidant capacity in an animal model of acute gastric ulcers.
2022 Physiological Research Mineral Water Vincentka and its Influence on Mucosal Ulcers BUDINSKAYA K, NÁDENÍČEK J, STRAČINA T, HENDRYCH M, PÍREK O, BARTÁKOVÁ A, et al.
Experimental Study Mineral Water Mucosal Ulcers Stomach Ulcer
This pilot study involved 16 male Wistar rats, divided into two groups: an experimental group and a control group, each with eight rats. The study was conducted in three phases: a 7-day handling phase, a 7-day phase where the experimental group received Vincentka mineral water and the control group received tap water, and a final phase of acute gastritis induction lasting one day. After 24 hours post-induction, the animals were sacrificed for analysis. Tissue samples from the stomach and duodenum, as well as blood samples, were examined using histological microscopy, immunohistochemical, and biochemical methods.
The histopathological analysis showed significantly less damage to the stomach lining in the experimental group compared to the control group. There were notable differences in blood plasma antioxidant capacity, oxidative stress parameters, and other biochemical values between the groups. These findings indicate that Vincentka mineral water positively affects the development and symptoms of acute gastric ulcers in this animal model, suggesting potential benefits for similar human conditions.
Apple cider vinegar intake can significantly decrease total cholesterol and fasting plasma glucose levels contributing to better cardiovascular health among adults.
2021 BMC Complementary Medicine and Therapies The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A
Systematic Review Apple Cider Vinegar Cholesterol HbA1C
The research process involved a thorough examination of electronic databases such as Medline, Scopus, Cochrane Library, and Web of Knowledge, from their creation until January 2020. The goal was to discover any clinical trial that explored the influence of apple cider vinegar (ACV) on lipid profiles and glycemic indicators. Studies where ACV was combined with other interventions or where the intervention duration was less than two weeks were excluded. To manage the differences between studies, a random-effects model was applied during the meta-analysis process comprising nine studies, including ten study arms.
ACV use demonstrated a remarkable decrease in total cholesterol and fasting plasma glucose (FPG) levels. However, there wasn't a noticeable impact observed on LDL-C, HDL-C, fasting insulin concentrations, or HOMA-IR serum levels. When analyzed further, it was found that a reduction in serum TC and TG occurred in a patient subgroup with type 2 diabetes, those who consumed less than or equal 15 mL/day of ACV, and those who consumed it for over 8-weeks. Consequently, a significant decrease in FPG levels was found in studies where participants consumed ACV for more than 8 weeks. Interestingly, FPG and HDL-C levels appeared to increase in participants who were otherwise healthy.
Honey exhibits significant anti-Helicobacter pylori activity, with at least 10% concentration proving effective in inhibiting gastric and duodenal ulcers, highlighting its therapeutic potential.
2020 Sains Malaysiana In vitro Study of Anti-Helicobacter pylori Activity of Honey: A Systematic Review Adam Q, Annuar F, Alfizah H, Mohd Fahami NA
Systematic Review Gastritis H Pylori Honey
The research involved a comprehensive review of 53 articles from electronic databases such as Medline via Ovid Medline, Scopus, and ScienceDirect spanning from 2000 to 2018. Selection criteria focused on studies reporting honey's effects on H. pylori-induced gastric and duodenal ulcers. Nine chosen articles detailed the positive impact of honey, suggesting a minimum 10% concentration as effective against H. pylori. The review underscores the need for further exploration into honey's active components and molecular mechanisms.
The positive outcomes reported in selected studies support honey's potential in inhibiting H. pylori infections, emphasizing the need for further investigations to elucidate the active components and underlying molecular mechanisms. The review sets the stage for future research aiming to provide robust evidence for the use of honey in clinical settings.
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