Insights & Discussion
Consuming bicarbonate-calcium mineral water, low in sodium, can help manage calcium imbalance and support bone health in perimenopausal women.
The study involved 120 perimenopausal women who consumed 2 liters of a specific bicarbonate-calcium mineral water (Lete) daily for six months. This water was chosen because it is rich in calcium and bicarbonate but low in sodium. The study aimed to determine the impact of this water on bone health and overall metabolism. The participants’ urine and blood serum were analyzed using NMR-based metabolomic procedures. These analyses were conducted to assess the effects of the water not only on calcium metabolism but also on the broader systemic metabolism.
The findings indicated that the Lete water effectively compensated for calcium dysmetabolism and supported bone health and integrity in perimenopausal women. While the study primarily focused on bone metabolism, it also provided insights into the potential system-wide metabolic effects of this specific type of mineral water. This suggests that such water could be a valuable dietary supplement for addressing calcium-related metabolic issues, particularly in perimenopausal women.
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A combination of soybean germ extract and a probiotic significantly improved menopause-related conditions and mood in an ovariectomized rat model.
2023 Nutrients Anti-Menopausal Effect of Soybean Germ Extract and Lactobacillus gasseri in the Ovariectomized Rat Model Lee SH, Lim TJ, Yun EJ, Kim KH, Lim S
Animal Study Menopause
The study employed an ovariectomized rat model to understand the effects of a combination of soybean germ extract containing 30% isoflavone and a probiotic. The methodology included assessing the effects of this combination on several health markers including body weight, estrogen markers, uterine and bone health, vascular markers, and neurotransmitter levels in these rats.
Once implemented, the combination of soybean germ extract and the probiotic showcased significant improvement in body weight and uterine and bone health of the rats. There were also noticeable effects on the lipid profile, liver function, and vascular markers. Most interestingly, the combination had a positive impact on the levels of serotonin and norepinephrine, indicating potential mood-enhancing effects, which are crucial in managing symptoms post-menopause. This essentially shows the potential of a dietary approach towards menopausal management, especially given the observed benefits without the side effects typically associated with hormone replacement therapy.
Saffron shows promising improvements in dealing with women's health issues related to labor, childbirth, premenstrual syndrome and menopause.
2023 Modern Care Journal Efficacy of Saffron (Crocus sativus L.) in Premenstrual Syndrome, Labor, Childbirth, and Menopause: A Systematic Review of Clinical Trials Irani M, Rahmanian A, Soltani N
Systematic Review Menopause
For the methodology, the investigators implemented a systematic review by utilizing the PICO process to explore various databases like PubMed, Scopus, Cochrane, among others, until February 2023. A strategically designed search was conducted using a set of keywords related to saffron and women's health conditions. From a pool of 164 articles, 20 randomized controlled trials that met the minimum score based on the Jadad scale were included in the study.
In terms of results, the investigation revealed that saffron holds positive impacts on labor and childbirth, such as enhancing Bishop's score, fostering labor progression, and reducing labor pain intensity and fatigue. Moreover, it helps with episiotomy healing and ameliorates mood swings and psychological symptoms associated with menopause and premenstrual syndrome. The study also acknowledges some influence of saffron on postpartum depression.
Soybean lettuce extract effectively reduces symptoms of menopause syndrome without notable side effects.
2022 Nutrients Evaluation of the Effectiveness of Fermented Soybean-Lettuce Powder for Improving Menopausal Symptoms Han AL, Lee HK, Chon HS, Pae HO, Kim MS, Shin YI, et al.
Randomised Controlled Trial Lettuce Menopause
The study targeted adult women suffering from menopausal syndrome with a Kupperman index of 15 or more. Participants were split into two groups – the experimental group and the placebo group. The research spanned over a four-week period and embraced a total of 39 participants (with one dropping out). Measurements of body mass index, waist circumference, and several cholesterol levels were taken before and after the study, but these didn't show any significant changes.
In the results discussion, the most notable finding was a significant reduction in the Kupperman index in the experimental group. They were given the natural nitric oxide-containing soybean lettuce extract. This decrease denotes the alleviation of menopausal symptoms, offering an effective, natural alternative to hormone therapy. Conversely, the placebo group didn't show any substantial change, reinforcing the efficacy of the soybean lettuce extract.
Current evidence shows that short-term honey supplementation following surgical or physiological menopause exerts an oestrogenic, antioxidant and anti-inflammatory effect on the female reproductive system.
2021 Molecules Augmentation of the Female Reproductive System Using Honey: A Mini Systematic Review Ismail NH, Ibrahim SF, Jaffar FHF, Mokhtar MH, Chin KY, Osman K
Systematic Review Female Reproductive System Honey Menopause
A systematic literature search using Scopus, MEDLINE via Ovid and Cochrane Library databases was conducted. Records were screened and identified for preclinical and clinical studies addressing the effects of HS on the FRS. Data on populations, interventions, outcomes and methodological quality were extracted. Studies were synthesised using tables and written summaries. Of the 198 identified records, six fulfilled the inclusion criteria. All six records were used for data extraction: two experimental studies using rats as the model organism and four human clinical studies of honey on female reproductive health. HS elevated the progesterone levels, restrained body weight increase, prevented uterine and vaginal atrophies in ovariectomised rats, attenuated symptoms of candidiasis and improved oxidative status in patients.
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
2021 Complementary Therapies in Medicine Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data Coyle ME, Liu J, Yang H, Wang K, Zhang AL, Guo X, et al.
Experimental Study Gan Mai Da Zao Tang Licorice Menopause
The methodology of this study involved exploring classical Chinese medicine textbooks to find the most frequent herbal mix used for symptoms similar to menopause. The approach taken was to sort and identify the formulas from the Encyclopedia of Traditional Chinese Medicine, a comprehensive resource in this field. Following this, a thorough review of randomized controlled trials was performed in order to determine the efficacy of the most common formula.
In terms of results, it was discovered that the Licorice and Jujube formula (LJF) was the most commonly found, mentioned in 36% of the analyzed references. The review of controlled trials revealed that the LJF might be effectively utilized for the improvement of sleep-related symptoms. Additionally, experimental studies hinted at potential benefits of the LJF, including sedative, antidepressant-like, estrogenic, and antiprogestogenic effects.
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