Insights & Discussion
Consuming carrots reduces the risk of gastric cancer by an indicated 26%.
Using specific search terms related to gastric cancer and carrot consumption, a comprehensive search through databases such as PubMed, Cochrane Library, Scopus, ScienceDirect, and some Persian databases was conducted. Comprehensive Meta Analysis/2.0 software was utilized for statistical analysis.
The initial search yielded 81 articles, but only 5 met the inclusion and exclusion criteria and were included in the study. Without mentioning specifics, a fixed effects model determined a significant reduction in the risk of gastric cancer associated with carrot consumption. The results showed no indication of publication bias through a funnel graph depiction. The results demonstrate an inverse relationship between carrot consumption and the risk of gastric cancer.
Discover Related Insights
Carrot consumption, beyond its β- and α-carotene content, significantly reduces cancer risk, highlighting polyacetylenes as potential anti-cancer agents, urging active promotion of carrot intake.
2023 SSRN Electronic Journal Carrot Intake is Consistently Negatively Associated with Cancer Incidence: A Systematic Review and Meta-Analysis of Prospective Observational Studies Ojobor CC, O'Brien GM, Siervo M, Ogbonnaya C, Brandt K
Systematic Review Carotene Carrot
The study conducted a comprehensive search across various databases for studies published until June 9, 2022, exploring the relationship between carrot intake, α-carotene intake, α-carotene plasma concentration, and cancer incidence. Involving 198 observational studies, the systematic review identified 50 prospective studies (52,000 cases) linking carrot intake (directly or as α-carotene) to a substantial reduction in cancer risk (RR 0.90, 95% CI 0.87–0.94, P < 0.0001). Additionally, 30 prospective studies (91,331 cases) examining plasma α-carotene levels revealed a similarly significant risk reduction (RR 0.80, 95% CI 0.72–0.89, P < 0.0001), with moderate inter-study heterogeneity (I2 = 36% and 26%) and nonsignificant interaction with cancer types.
The findings emphasize the robust association between carrot consumption and decreased cancer risk, urging active encouragement of carrot intake. While α-carotene was used as a marker, the study suggests the need for further investigations into non-carotene-focused hypotheses to understand the underlying mechanisms of this association.
Regular consumption of raw carrots is associated with a significant, dose-dependent reduction in lung cancer incidence, suggesting a potential cancer-protective effect attributed to polyacetylenic compounds, particularly falcarinol and falcarindiol, present in raw carrots.
2023 Nutrients Carrot Intake and Risk of Developing Cancer: A Prospective Cohort Study Deding U, Baatrup G, Kaalby L, Kobaek-Larsen M
Cohort Study Adenocarcinoma Cancer Carrot
This research involved a long-term study of 55,756 Danish citizens over a period of more than 25 years. The focus was on investigating the relationship between regular consumption of raw carrots and the development of various cancers, predominantly adenocarcinomas and leukemia. The study assessed whether the frequency of carrot consumption influenced the incidence of lung, pancreatic, breast, prostate cancer, and leukemia. Additionally, it compared the effects of eating raw versus processed carrots.
The study found that eating raw carrots regularly was associated with a reduced occurrence of lung cancer. This link was less clear for pancreatic cancer and non-existent for breast and prostate cancer. The research suggested that the cancer-preventive properties of raw carrots could be attributed to specific compounds, namely falcarinol and falcarindiol. These compounds are not present in cooked carrots. This significant finding points towards the potential of raw carrots in cancer prevention, particularly for lung cancer.
Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.
2023 Journal of the Science of Food and Agriculture Carrot and carotene and multiple health outcomes: an umbrella review of the evidence Yi X, Li J, Liao D, Peng G, Zheng X, Xu H, et al.
Review Article Alzheimer's Disease Anticancer Breast Cancer
An umbrella review methodology was adopted to identify connections between carrot and carotene intake and various health outcomes. We turned to databases such as Web of Science, PubMed, and Embase to find the needed data. The analysis included the collected evidence from both interventional and observational studies that focused on carrots, carotene, and any related health impact. To estimate the summary effect size for each correlation, both random and fixed effects models were employed.
The study reviewed a total of 1329 studies and utilized the data from 30 meta-analyses with 26 health outcomes that fit the eligibility requirements. These featured outcomes related to various types of cancer, fractures, age-related cataract, sunburn, and Alzheimer's disease. The associations were analyzed between the health outcomes and the intake of carrots, intake of carotene, and serum carotene levels.
Crocin, a compound derived from saffron, has shown considerable potential in hindering tumor growth and improving immune status, across various malignant tumors.
2023 PeerJ Advances on the anti-tumor mechanisms of the carotenoid Crocin Bao X, Hu J, Zhao Y, Jia R, Zhang H, Xia L
Review Article Anti-Tumour Breast Cancer Cervical Cancer
The methodology for the study involved an in-depth review of modern pharmacological studies that have analyzed the therapeutic effects of crocin, a natural compound that can be extracted from saffron. Various anti-tumor effects were assessed including the induction of tumor cell death (apoptosis), restrictions on tumor cell proliferation, and potential barriers to invasion and metastasis of these cells. The potential for enhancement of sensitivity to chemotherapy and improvement of immune status were also examined.
Following the review, the study revealed that crocin has significant anti-tumor properties. It showed that this natural compound can induce apoptosis in tumor cells, inhibit their expansion and progression, and even prevent their invasiveness and metastasis. Furthermore, crocin demonstrated the potential to enhance the body’s responsiveness to chemotherapy and help boost the immune system. These effects were observed across a range of different malignant tumors, including stomach, liver, cervical, breast, and colorectal cancers.
Consuming carrots can significantly decrease the risk of cancer.
2023 Critical Reviews in Food Science and Nutrition Carrot intake is consistently negatively associated with cancer incidence: A systematic review and meta-analysis of prospective observational studies Ojobor CC, O’Brien GM, Siervo M, Ogbonnaya C, Brandt K
Meta-Analysis Cancer Carrot
The methodology used in this research involved examining the links between carrot intake and the incidence of cancer. The scope was broad, examining all studies published before June 2022 that offered risk estimates connecting cancer incidence with either carrot consumption, α-carotene intake, or α-carotene plasma levels. Possible sources of such studies included those found via digital searches, manually identified within other studies, or garnered from existing reviews. Analysis was carried out comparing the highest and lowest reported intakes from prospective studies, estimating summary relative risks using a random-effects model.
The study's results indicated a strong correlation between carrot consumption and a notable reduction in cancer risk. This conclusion was derived from the analysis of 198 observational studies, 50 of which were prospective studies involving a total of 52,000 cases that specifically recorded carrot intake. Comparatively, on the correlation between α-carotene plasma levels and cancer risk, analysis from 30 prospective studies with 9,331 cases indicated that a higher presence of α-carotene also resulted in decreased cancer risk. Despite a moderate variance between studies, these findings serve as significant evidence in support of the anticancer benefits of carrots.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.