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Concentrated pomegranate juice consumption can potentially lower cardiovascular disease risk factors in women with polycystic ovary syndrome.
The study used a randomized clinical approach, enrolling 44 women identified with polycystic ovary syndrome, aged 18 to 40 years and above a certain body weight index. These participants were randomly divided into two groups: one group was given concentrated pomegranate juice (CPJ), while the other served as a control. Both groups were monitored over a period of 8 weeks, with baseline measurements taken for anthropometric measures, blood pressure, and biochemical parameters set at the onset and then compared at the end of the trial.
Upon completion, the group that consumed CPJ showed reductions in blood pressure and serum triglyceride levels — a known risk factor for cardiovascular diseases. There was also an increase in the amount of high density lipoprotein-cholesterol (good cholesterol) and a decrease in the triglyceride to high-density lipoprotein-cholesterol ratio. However, an increase was observed in levels of low-density lipoprotein-cholesterol (bad cholesterol). No adverse events or complications arose from CPJ consumption during the study period.
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Green tea helps alleviate symptoms in multiple benign gynecological disorders, primarily due to a compound called Epigallocatechin-3-gallate.
2023 Nutrients Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage? Hazimeh D, Massoud G, Parish M, Singh B, Segars J, Islam MS
Review Article Adenomyosis Endometriosis PCOS
The paper reviews the role of the compound Epigallocatechin-3-gallate found in green tea, and its effects on various benign gynecological conditions. The compound is noted for its antioxidant and prooxidant qualities, allowing it to interact with multiple cellular pathways that are crucial for disease pathogenesis. The studied conditions include uterine fibroids, endometriosis, dysmenorrhea, adenomyosis, menopause, and polycystic ovary syndrome. The research accounts for the specific mechanisms through which the compound might affect each condition, such as anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms.
The results suggest that green tea consumption can lead to improved symptom management in these disorders. It was found to lessen the intensity of symptoms associated with uterine fibroids and endometriosis, by invoking anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms. It also helped manage pain linked with dysmenorrhea and adenomyosis through reducing uterine contractility and widely felt pain. Additionally, it showed efficacy in weight and osteoporosis control during menopause, and showed potential benefits in managing polycystic ovary syndrome. However, claims regarding its influence on fertility were deemed controversial.
The compounds apocarotenoids and carotenoids found in saffron extract could potentially interact with multiple targets, helping to manage the symptoms of polycystic ovary syndrome.
2023 Medicine Network pharmacology-based strategic prediction and target identification of apocarotenoids and carotenoids from standardized Kashmir saffron (Crocus sativus L.) extract against polycystic ovary syndrome Tiwari A, Modi SJ, Girme A, Hingorani L
Network Pharmacology PCOS
The study utilized a network pharmacology-based approach to identify the possible therapeutic pathways for apocarotenoids and carotenoids in Crocus sativus on polycystic ovary syndrome. The Ultra-High-Performance Liquid Chromatography with Photodiode Array detector (UHPLC-PDA) standardized stigma-based Crocus sativus extract (CSE) was analyzed for these phytochemicals.
Information about polycystic ovary syndrome related genes was collected from a knowledge database and networks were established between these targets and Crocus sativus extract phytochemicals to understand its mechanism of action.
Through network analysis and screening conditions, the study found four significant targets, including serine/threonine kinase 1, signal transducer and activator of transcription, and two types of mitogen-activated protein kinases. Gene ontology and Kyoto Encyclopaedia of genes and genomes analysis showed that MAP kinase and serine-threonine pathways were crucial targets in polycystic ovary syndrome.
Further molecular docking studies were conducted, and carotenoids apocarotenoids were assessed for absorption, distribution, metabolism, excretion, and toxicity predictions. Elements like crocetin, picrocrocin, and safranal showed strong binding affinity for the identified targets. This analysis also revealed that these compounds had excellent bioavailability and could cross the blood-brain barrier without demonstrating toxicity.
In summary, the study demonstrated that these phytochemicals could act on the identified targets, thus pointing towards the potentiality of Crocus sativus extract in managing polycystic ovary syndrome.
In women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones.
2022 Frontiers in Nutrition A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, et al.
Randomised Controlled Trial Ceylon Cinnamon Cinnamon FSH
In the methodology of the study, 100 women diagnosed with polycystic ovary syndrome were divided into four groups. Each group received a different treatment: cinnamon, ginger, metformin, or placebo. The dosage for these treatments was 500 mg, three times a day, administered over a period of 8 weeks. The participants' sex hormones, weight revelations, along with glycemic and lipid markers were monitored before and after this period. Several participants were disqualified because of unspecified factors, resulting in a final sample size of 83.
In terms of results, all groups saw a decrease in weight and body mass index. The metformin and cinnamon groups specifically had notably decreases in their insulin resistance, meaning that these treatments were effective in improving metabolic health. Additionally, the ginger group experienced a reduction in follicle-stimulating hormone and luteinizing hormone levels unlike the other groups. Testosterone levels were lowered in the metformin and cinnamon groups, but no significant changes in dehydroepiandrosterone were observed in any of the groups. These results indicate the potential use of cinnamon and ginger as alternative treatments in managing polycystic ovary syndrome.
Green tea supplementation can significantly reduce body weight in women with polycystic ovary syndrome, hence potentially beneficial in its clinical management.
2022 Nutrition Research Green tea promotes weight loss in women with polycystic ovary syndrome: Systematic review and meta-analysis Colonetti L, Grande AJ, Toreti IR, Ceretta LB, da Rosa MI, Colonetti T
Meta-Analysis Body Weight Green Tea Obesity
The research carried out was a systematic review of randomized controlled trials that focused on women with polycystic ovary syndrome, examining the effects of green tea supplementation versus a placebo. Relevant studies were sourced from electronic databases such as MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Library, LILACS via BVS, and Web of Science using specific terms related to the illness and green tea. Criteria for the evaluation included effects on body weight, fasting insulin, body mass index, body fat percentage, daily caloric intake, waist and hip circumference, and the waist/hip ratio.
Among the studies considered, there were a total of 169 women, with 85 allocated to the green tea group and 84 to the placebo group. It became apparent that there was a significant reduction in body weight for the group that received green tea supplementation. This leans towards the potential of green tea to be beneficial in the management of this syndrome.
The addition of CHM to clomiphene may improve pregnancy rates.
2021 Cochrane Database of Systematic Reviews Chinese herbal medicine for subfertile women with polycystic ovarian syndrome Zhou K, Zhang J, Xu L, Lim CED
Systematic Review PCOS
The study aimed to assess the effectiveness and safety of Chinese herbal medicine (CHM) for subfertile women with polycystic ovarian syndrome (PCOS). They conducted a comprehensive search across databases and trials registries, ultimately including eight randomized controlled trials with 609 participants. The trials compared various interventions, such as CHM versus clomiphene, CHM plus clomiphene versus clomiphene alone, CHM plus other treatments versus those treatments alone. The evidence quality was generally very low, and the primary outcome of live birth rate was not reported. While some comparisons suggested potential benefits, such as the addition of CHM to clomiphene leading to higher pregnancy rates, the overall uncertainty and lack of consistent evidence hindered conclusive findings. The study underscores the need for well-designed trials focusing on live birth rates and safety indicators in assessing the use of CHM for subfertile women with PCOS.
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