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Green tea's catechins demonstrate therapeutic effects against neurodegenerative diseases via anti-inflammatory, antioxidant actions, and activating diverse brain cellular pathways.
The research primarily evaluates the effect of polyphenolic compounds found in green tea, known as catechins, on neurodegenerative diseases. By conducting several interventional and observational studies on humans, the research explores the anti-cancer, anti-obesity, antidiabetic, anti-inflammatory, and neuroprotective properties of these compounds. The biological, pharmacological, antioxidant, and metal chelating abilities of catechins, particularly their influence on different cellular pathways within the brain, are intensively studied.
The results elucidate that catechins exhibit multiple neuroprotective effects. Their anti-inflammatory and antioxidant properties help to inhibit excessive production of cytokines, and inflammatory pathways, while also controlling metal ions and free radicals. Researchers have further established that catechins may curb the phosphorylation of the tau protein and aggregation of amyloid beta, both key markers in neurodegenerative diseases. Additionally, these compounds show potential in reducing alpha-synuclein levels and augmenting dopamine levels. Hence, they significantly contribute to the prevention and treatment of neurodegenerative diseases, including Alzheimer's, Parkinson's, multiple sclerosis, and cognitive deficits.
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Honey exhibits multifaceted benefits for brain health, acting as a memory booster, neuroprotective agent, anti-stress, and anti-nociceptive substance, fostering potential therapeutic applications to enhance overall cognitive well-being.
2023 Frontiers in Aging Neuroscience Honey on brain health: A promising brain booster Zamri NA, Ghani N, Ismail CAN, Zakaria R, Shafin N
Review Article Brain Health Cognitive Function Honey
This review scrutinizes 34 original articles exploring the impact of honey on brain health. Honey, traditionally known as a natural sweetener, emerges as a versatile substance with applications in nutrition, health supplementation, and brain health enhancement. The analysis identifies four key benefits: memory enhancement, neuroprotection, stress reduction, and pain alleviation. The review emphasizes the growing interest in understanding the mechanisms that underlie these effects, paving the way for potential therapeutic roles of honey in promoting cognitive well-being.
The literature review underscores the significant role of honey in brain health research, shedding light on its diverse benefits, including memory improvement, neuroprotection, stress mitigation, and pain relief. The emphasis on unraveling the underlying mechanisms reflects a broader interest in establishing honey's therapeutic potential for enhancing overall brain health. This comprehensive exploration of honey's effects on cognition opens avenues for developing novel therapeutic strategies harnessing honey's natural properties.
Magnesium, essential for harmonising nerve signals and preserving the blood-brain barrier, may be linked to neurodegenerative disorders when its balance is disrupted.
2022 International Journal of Molecular Sciences Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration Maier JAM, Locatelli L, Fedele G, Cazzaniga A, Mazur A
Review Article Alzheimer's Disease Magnesium Multiple Sclerosis
The researchers performed a narrative review, beginning with a quick overview of the role of magnesium in the brain. Magnesium is crucial for healthy nerve signal transmission and the upkeep of the blood-brain barrier, which protects the brain from harmful substances in the blood. Then, they discussed evidence suggesting a connection between disrupted magnesium balance and a variety of neurodegenerative disorders.
In the discussion of the results, it was posited that a deficiency in magnesium might contribute to low-grade systemic inflammation, which is common in many illnesses. Specifically, they argued that such inflammation in the brain is a characteristic feature of neurodegenerative diseases. The review found evidence that disruptions in the body's magnesium balance could be associated with multiple sclerosis, Alzheimer's, and Parkinson's diseases.
Fermented soybean products alleviate and possibly prevent neurodegenerative conditions, including Parkinson's and Alzheimer's diseases.
2021 Foods Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases Jang CH, Oh J, Lim JS, Kim HJ, Kim JS
Review Article Alzheimer's Disease Neurodegenerative Diseases Parkinson's Disease
The study involved the fermentation of cooked soybeans with specified bacteria and fungi species, a process known to produce a range of bioactive compounds. These unique compounds, which are most often beneficial to health, are contained in fermented soybean products that are a staple in East Asian diets.
In analyzing the results, the focus was on the potential of these fermented soy foods and their components in managing neurodegenerative diseases. Notably, the findings suggested a significant preventive and curative effect of these products on such ailments as Alzheimer's and Parkinson's diseases. The paper, therefore, presents fermented soy foods as potentially reliable natural solutions to these neurodegenerative conditions.
These reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases.
2020 Nutrients Beneficial Effects of Walnuts on Cognition and Brain Health Chauhan A, Chauhan V.
Systematic Review Alzheimer's Disease Brain Health Cognitive Function
Walnuts contain several components that have antioxidant and anti-inflammatory effects. Animal and human studies from our and other groups suggest that supplementation with walnuts in the diet may improve cognition and reduce the risk and/or progression of mild cognitive impairment and Alzheimer's disease.
Furthermore, several animal and human studies have suggested that walnuts may also decrease the risk or progression of other brain disorders such as Parkinson’s disease, stroke, and depression, as well as of cardiovascular disease and type 2 diabetes. Together, these reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases.
High phenolic early harvest extra virgin olive oil shows notable improvement in cognitive function compared to a moderate phenolic version and the Mediterranean diet alone.
2020 Journal of Alzheimer's Disease A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study Tsolaki M, Lazarou E, Kozori M, Petridou N, Tabakis I, Lazarou I, et al.
Clinical Study Alzheimer's Disease Cognitive Function Extra Virgin Olive Oil
A randomized prospective study was conducted examining the effects of high phenolic early harvest extra virgin olive oil (HP-EH-EVOO) and moderate phenolic extra virgin olive oil (MP-EVOO) against the Mediterranean Diet (MeDi) in individuals with mild cognitive impairment. Participants were genetically tested for susceptibility to Alzheimer's disease and had their cognitive functions tested at the start and after 12 months. They were then randomly put into one of three groups: those who received HP-EH-EVOO, those who received MP-EVOO, and those who only received instructions on following the MeDi.
The results showed that participants who consumed HP-EH-EVOO demonstrated better cognitive performance in almost all areas over the course of the study, compared to those who consumed MP-EVOO and those who followed the MeDi. MP-EVOO consumers also demonstrated noticeable cognitive improvement compared to the MeDi group, who exhibited worse or similar cognitive performance to their baseline in almost all areas. Moreover, participants who consumed either form of olive oil performed better in cognitive tests, regardless of their predisposition to Alzheimer's disease.
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