Insights & Discussion
Chrysanthemums, popular floricultural crops, not only hold significant ornamental value but also exhibit various therapeutic potentials including antioxidant, antimicrobial, and anticancer activities.
The method involved in this research aimed at studying the genus Chrysanthemum through a decade-long review (2010-2020) of scientific evidence, focusing on its therapeutic potential, phytochemistry, and pharmacological activities. Various phytochemical compounds including flavonoids, terpenoids, polysaccharides, and unsaturated fatty acids, which are present in the genus Chrysanthemum, were identified. In addition, the taxonomy, distribution, horticultural, and traditional uses of the genus were also studied.
The results demonstrated that Chrysanthemum species show numerous potential medicinal benefits, ranging from antioxidant to antimicrobial, anti-inflammatory, anticancer, anti-allergic, anti-obesity, immune regulation, hepatoprotective and nephroprotective activities. The research also underlined the opportunity of medicinal exploitation of the genus Chrysanthemum, given the extreme popularity of these plants and the wide range of phytochemical compounds they contain. The ornamental, medicinal, environmental, and industrial values of these plants further establish them as leading floricultural crops.
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Pumpkin seeds are recognised for their medicinal, nutritional, and cosmetic benefits, including anti-diabetic, heart disease prevention, anti-cancer, and antioxidant qualities.
2024 The Natural Products Journal Pumpkin Seeds (Cucurbita spp.) as a Nutraceutical Used In Various Lifestyle Disorders Wal A, Singh MR, Gupta A, Rathore S, Rout RR, Wal P
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The review article undertakes a comprehensive exploration of the nutraceutical importance of pumpkin seeds. The methodology includes an examination of the various known substances in the seeds, such as phytoestrogens, unsaturated fatty acids, and vitamin E. The study then delves into the different benefits and therapeutic uses of these components stretching from medicinal to nutritional to cosmetic applications.
The results of this research are diverse and impressive, with implications for several major health sectors. Their potential anti-diabetic and hypoglycemic properties could suggest a significant role in the management and prevention of diabetes. Meanwhile, the seeds' potential in cardiovascular disease prevention could help to address one of the most pressing global health issues. Moreover, potential anti-cancer properties imply that these seeds could even have a part to play in cancer prevention. The review also described potential additional qualities, such as antidepressant, anti-helminthic (parasite-removing), and antioxidant effects.
Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.
2023 Food Chemistry Advances The whole pomegranate (Punica granatum. L), biological properties and important findings: A review Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, et al.
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In the methodological approach of the study, a comprehensive review was undertaken to collate information on the bioactive components found within pomegranates and their by-products (aril, seed, and peel). The study emphasized the pomegranate peel's properties owing to its high content of the bioactive compounds. The aim was to elucidate the nutritional and functional aspects of pomegranates, particularly as a functional food.
The results outlined that pomegranates, especially their peel, contain bioactive compounds, including punicalagin, punicalin, ellagic acid, punicic acid, and anthocyanins. Therefore, they have potential functional properties such as antimicrobial, anticancer, and antiviral characteristics. These results suggest that pomegranates could be explored to develop nutraceutical or functional food products due to their profound properties. The peel of the pomegranate, specifically, showcases significant potential for development due to its higher bioactive compound content compared to other parts of the fruit.
The compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside from chrysanthemum flowers demonstrated superior antioxidant and anti-osteoporosis effects.
2023 Journal of Science and Technology - HaUI Investigate the antioxidant and anti-osteoporosis activities of compounds isolated from chrysanthemum indicum flowers Le The Hoai, Nguyen Thi Huong, Bui Thi Thu Trang
Experimental Study Antioxidant Chrysanthemum Osteoporosis
The research involved isolating five compounds from Chrysanthemum indicum L flowers: Syringin, Dihydrosyringin, Benzyl-O-β-D- glucopyranoside, -Phenylethoxy-O--D-glucopyranoside, and (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside. The identification and structure determination of these compounds were performed via the interpretation of their 1D - NMR spectra and comparison to established literature. The collected compounds were then assessed for their antioxidative and anti-osteoporosis activities.
During the analysis of results, it was observed that the compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside exhibited significantly higher antioxidant activity and anti-osteoporosis effects compared to the others. It showed a strong capacity for peroxyl radical scavenging, surpassing the protection offered by the standard Trolox. Dihydrosyringin also demonstrated a good reducing capacity, as indicated by its CUPRAC values. Furthermore, (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside displayed strong inhibitory effects on osteoclast differentiation, indicating its potential as an anti-osteoporosis agent.
Chrysanthemum morifolium contains natural bioactive compounds, including 29 types of phenolics, which display significant antioxidant activity.
2023 Egyptian Journal of Chemistry Chemical Investigation of Phenolic Profiles and Antioxidant Activity of Chrysanthemum morifolium Youssef H, Ali S, Sanad M, Dawood D
Experimental Study Antioxidant Chrysanthemum
The study determined the antioxidant properties of Chrysanthemum morifolium by using methanol and ethyl acetate as solvents to extract and then analyse the plant's phenolic profile. The antioxidant activity was assessed with three separate in vitro tests: a reducing power assay, a Phosphomolybdenum antioxidative power assay, and the testing of inhibition of free radical 1,1-di phenyl-2-picryl hydrazyl. The content of total phenolics and total flavonoids was measured using the Folin Ciocalteu reagent, yielding a range of values.
In relation to the results, it was established that the examined plant was a significant source of bioactive compounds with notable antioxidant properties. A total of 29 phenolics, divided into 15 phenolic acids and 14 flavonoids were identified and quantified using high-performance liquid chromatography. Ellagic acid was the most present phenolic in the methanol extract and ethyl acetate fraction of green aerial parts. Meanwhile, Hesperidin was the most common flavonoid in the flower methanol extract. The ethyl acetate fraction from the flowers showed the highest efficiency in all tested antioxidant methods, indicating that different parts of the plant can vary in their antioxidant potential.
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
2022 Pharmacological Research - Modern Chinese Medicine Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
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The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19.
Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.
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