Saffron possesses major bioactive compounds such as safranal, crocin, and picrocrocin that are hypothesized to be integral to its antidepressant effects.
2018 Journal of Pharmacy And Bioallied Sciences Saffron (Crocus sativus L.): As an antidepressant Siddiqui MJ, Saleh MSM, Basharuddin SNBB, Zamri SHB, Mohd Najib MH, Che Ibrahim MZ, et al.
Review Article Benefit Crocin Depression
In this research, a chemical analysis was undertaken on the saffron plant, a perennial herb native to various mountainous regions, ranging from Asia Minor to India. During this in-depth analysis, the researchers identified and elucidated almost 150 volatile and nonvolatile compounds from the plant. A key focus of the analysis was the three major bioactive compounds - safranal, crocin, and picrocrocin, believed to be the primary factors behind saffron's aroma and bitter taste.
On the subject of the findings, it was concluded that these major bioactive compounds are likely playing a pivotal role in the medicinal potential of the saffron plant. Specifically, the plant's well-documented antidepressant properties could largely be attributed to these compounds. The study also focused on the pharmacokinetic and pharmacodynamic properties of the plant, indicating that saffron could have efficacious and safe potential for use. It was inferred that this potential mainly pertains to its antidepressant effects, spurring increased interest in further exploration of its assorted bioactive compounds.
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