Insights & Discussion
Regular intake of goji berries can increase Macular Pigment Optical Density, potentially helping to prevent or delay the development of age-related macular degeneration.
The research was a randomized, parallel-arm study involving 27 participants aged between 45 and 65. These participants were divided into two groups; one group consumed 28 grams of goji berries five times weekly for 90 days, while the other consumed a supplement containing 6mg of lutein and 4mg of zeaxanthin in the same frequency and duration. This method intended to evaluate the effects of zeaxanthin-rich goji berry intake on Macular Pigment Optical Density and skin carotenoids, both key in AMD risk assessment, while also drawing a comparison to the effects of lutein and zeaxanthin supplements.
As the study progressed to its end, the group consuming goji berries showed a significant increase in Macular Pigment Optical Density and skin carotenoids, key biomarkers in assessing the risk of developing age-related macular degeneration. The lutein and zeaxanthin supplement group, however, did not present any noteworthy changes. This suggests the potential superiority of goji berries in the prevention or delay of AMD development compared to the given supplement.
Discover Related Insights
Greater intake of blueberries considerably decreases the risk of age-related macular degeneration, while a remarkable dietary intake of anthocyanins inversely correlates with cataract incidents.
2024 The Journal of Nutrition Intake of Blueberries, Anthocyanins, and Risk of Eye Disease in Women Sesso HD, Rautiainen S, Park SJ, Kim E, Lee IM, Glynn RJ, et al.
Cohort Study Age-Related Macular Degeneration Anthocyanins Blueberry
Middle-aged and older women, numbering 36,653 and 35,402 originally without cataract and AMD, provided data for the study via semiquantitative food frequency questionnaires. Insights were derived on the consumption of blueberries by these women, with frequency varied from none to over two servings weekly. Additionally, total anthocyanin consumption was analysed, with major subclasses adjusted for energy and then into quintiles. Self-reported risk factors for eye diseases were adjusted in the multivariable hazard ratios.
On analysis, it was found that a significant portion of participants consumed a minimum of one serving of blueberries weekly. Thus, compared to no blueberry intake, it was observed that those consuming the fruit exhibited a decrease in the total instances of AMD, while visually significant AMD remained unaffected. Furthermore, dietary anthocyanin showed a modest yet significant inverse association with cataract occurrences, but no notable correlation with AMD.
Acupuncture, either alone or as an adjunct, improved the clinical efficacy and visual acuity of age-related macular degeneration patients, particularly those with dry AMD.
2023 PLOS One Effects of acupuncture on age-related macular degeneration: A systematic review and meta-analysis of randomized controlled trials Sun W, Zhao Y, Liao L, Wang X, Wei Q, Chao G, et al.
Meta-Analysis Acupuncture Age-Related Macular Degeneration
The study conducted a meta-analysis on nine out of 226 articles selected from various databases such as PubMed, Ovid Medline, Embase, Cochrane Library, The Chinese National Knowledge Infrastructure Database, VIP, Wanfang, and SINOMED up until September 4, 2022. Two separate reviewers independently carried out the literature screening and data extraction and used RevMan 5.4 software for the meta-analysis.
In the discussion of the results, it was found that 508 AMD patients (representing a total of 631 eyes), including 360 dry eyes and 271 wet eyes, showed improvement in both clinical efficacy and best-corrected visual acuity after receiving acupuncture treatment. The treatment also led to a reduction in their central macular thickness. However, while the benefits of acupuncture were seen, the quality of evidence supporting these outcomes was judged as ranging from "low" to "very low".
Chrysanthemum extract has protective effects on light-damaged retinas, reducing oxidative stress and improving cellular viability.
2022 BMC Complementary Medicine and Therapies The effect of a chrysanthemum water extract in protecting the retina of mice from light damage Gong Y, Wang X, Wang Y, Hao P, Wang H, Guo Y, et al.
Experimental Study Age-Related Macular Degeneration Chrysanthemum
The experiment incorporated both in-vitro and in-vivo tests. In the lab, ARPE-19 cells were divided into four groups (control, light-damaged, low-dose extract, high-dose extract), treated with varying levels of chrysanthemum extract, and then exposed to light. Cellular viability and reactive oxygen species production were then observed. A similar grouping approach was used with C57BL/6J mice, where chrysanthemum extract concentration was administered before light exposure. The retinas were evaluated for function, morphology, and apoptosis post-exposure.
Light-damage caused a decrease in cellular viability and an increase in reactive oxygen species production. However, treatment with chrysanthemum extract showed improvement in viability and reduction in reactive oxygen species. In mice, light damage caused dysfunction in the retinas, destruction of morphology and increased apoptosis, particularly in the retinal pigment epithelium and photoreceptor layer. Again, chrysanthemum extract treatment improved retinal function, maintained retinal structures, and reduced apoptosis. The extract achieved this by increasing concentration of anti-oxidative enzymes.
Phytochemicals in carrots, particularly carotenoids, are effective at reducing eyesight degeneration and treating chronic eye defects due to their antioxidant and anti-inflammatory properties.
2021 SSRN Electronic Journal The Nutraceutical potential of Carrots carotenoids in Chronic Eyes Defects (CEDs): A Review Taiwo EA, Abdulkareem TT, Fajemisin E
Review Article Age-Related Macular Degeneration Carrot Cataracts
Throughout the review process, seventy original research and review articles were examined, all published between 2000 and 2020 across four major journal databases: Elsevier, PubMed, ResearchGate and Plos One. The focus of the search was directed by six keywords, centring on both in-vivo and in-vitro study results related to the topic of interest.
Among the various findings, it was consistently revealed that carrots contain a multitude of bioactive compounds, notably carotenoids, which have been proven to be effective in halting and treating eye degenerations including Nyctalopia, Myopia, Cataracts, Age-related Macular Diseases and Glaucoma. Carotenoids have been found to work as potent antioxidants and anti-inflammatory agents, defending eyes against vision loss due to oxidative stress. Thus, the increased consumption of carrots can potentially serve as a natural therapeutic approach and enhancer of vision.
Goji berry supplementation can improve macular pigment and visual acuity in patients with early age-related macular degeneration by increasing serum zeaxanthin levels.
2018 International Journal of Ophthalmology Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration Shang Li, Na Liu, Li Lin, et al.
Randomised Controlled Trial Age-Related Macular Degeneration Goji Berry Zeaxanthin
In this prospective, randomized controlled study, 114 patients, aged 51 to 92 and with early age-related macular degeneration, were divided into two groups. One group was given a daily supplementation of 25 grams of Goji berries for 90 days while the control group continued with their normal diet. The study used Heterochromatic Flicker Photometry to measure the Macular Pigment Optical Density (MPOD) and High-Performance Liquid Chromatography to analyze the levels of serum lutein and zeaxanthin. These were recorded at the beginning and at the end of the study.
In the Goji berry group, by the end of the study, there was no significant change in serum lutein levels. However, there was an increase in serum zeaxanthin levels which coincided with the group's improvement in MPOD. In comparison to the control group, the Goji group had higher zeaxanthin levels and MPOD. The visual acuity of the Goji berry group also showed a relative decrease compared to the baseline. These results suggest Goji berry supplementation can beneficially impact early age-related macular degeneration patients by boosting serum zeaxanthin levels, thus raising MPOD and improving visual acuity.
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