Insights & Discussion
Clinical trials categorize botanical parts of date palm as being most effective in eight different areas such as obstetrics, oncology, and endocrinology.
In the study, a comprehensive review was conducted on all types of clinical trials (including randomized, pilot, quasi-experimental, cross-over, and non-randomized) assessing the clinical impacts of date palm for the period between 2000 to August 2019. These trials were sourced from both English and Persian language papers. The methodological quality of these trials was scrutinized based on the risk of bias assessment laid out by the Cochrane handbook of systematic reviews and subsequently, results were reported via the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement.
The study saw twenty-six research works fitting the criteria set for inclusion. These studies spanned across eight categories based on the varied botanical derivatives of the date palm. These categories consisted of fields like obstetrics, gynecology, oncology, dermatology, hematology, gastroenterology, endocrinology, metabolism, and infertility. However, there were concerns raised regarding existing biases in trial conduction, with about 80% of the studies indicating performance and detection bias, roughly half indicating selection bias, and about 20% indicating attrition and reporting bias. Regardless, these clinical trials provide useful insights into the possible health benefits of various date palm components.
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The ethanol extract from adzuki beans significantly reduces lung metastasis and invasion of melanoma cells, showing potential for functional food development.
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The methodology of the study involved extracting the 40% ethanol eluent from the fraction of hot-water extract from adzuki beans adsorbed onto a type of resin. This extract, dubbed EtEx.40, was then tested on B16-BL6 melanoma cells, examining specifically its effects on adhesion, migration, and invasion into extracellular matrix components and their invasion into reconstituted basement membrane (colloquially referred to as matrigel), while ensuring it did not affect cell proliferation in vitro.
The results illustrated a significant difference in the presence of tumor colonies when treated with EtEx.40. The extract showed a considerable inhibitory effect on the experimental lung metastasis, as well as the invasion of the melanoma cells. Furthermore, the adhesion and migration of the melanoma cells into the extracellular matrix components were also reduced. The results demonstrated a strong antimetastatic role of the ethanol extract of adzuki beans.
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
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This quasi-experimental study with a pretest-posttest design involved 30 pregnant women divided into two groups: one receiving Fe (Control Group) and the other Honey + Fe (Intervention Group) for 60 days. Blood and urine analyses revealed a remarkable increase in hemoglobin levels in the Honey + Fe group (2.80 ± 0.26 g/dl), surpassing the Fe control group (0.80 ± 0.13 g/dl). Moreover, the Intervention Group demonstrated a notable decrease in 8-Ohdg levels (-4.23 ± 1.32 nmol/ml, p = 0.031), indicating reduced oxidative stress, while the Fe control group exhibited less significant changes (2.98 ± 1.30 nmol/ml, p = 0.322). Independent T Test confirmed the Honey + Fe group's superior effectiveness in increasing hemoglobin levels and decreasing 8-Ohdg levels in anemic pregnant women (p = 0.001 and p = 0.002, respectively).
The study underscores the synergistic benefits of honey and iron supplementation in enhancing hemoglobin levels and mitigating oxidative stress among anemic pregnant women. The robust findings, supported by statistical significance, emphasize the potential clinical relevance of incorporating honey into anemia management strategies, offering a more effective approach compared to iron supplementation alone.
Purple carrot roots, rich in bioactive compounds like anthocyanin, may be effective in preventing metabolic syndrome and cancer by reducing inflammation and metabolic changes.
2022 Applied Sciences Delving into the Nutraceutical Benefits of Purple Carrot against Metabolic Syndrome and Cancer: A Review Rasheed H, Shehzad M, Rabail R, Kowalczewski P, Kidoń M, Jeżowski P, et al.
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The methodology employed in the research deeply studies the role of purple carrot’s main bioactive compounds against metabolic syndrome and cancer. The main focus lies on anthocyanin, a phenolic compound present in purple carrot roots. This natural food source was shifted towards as a healthier nutritional approach instead of dietary supplements. The research leans on the effectiveness of these compounds in evading or delaying the onset of cardiovascular diseases, obesity, diabetes, and cancer by inhibiting inflammatory effects.
The discussion primarily surrounds the role of bioactive compounds found in purple carrots, specifically anthocyanin, in their potential prevention of metabolic syndrome and cancer. The study focused on how these components could disrupt the onset of cardiovascular disease, obesity, diabetes, and similar health issues. The results suggest that these compounds were successful in decreasing metabolic changes and inflammation. It has been suggested that purple carrots' inherent components might serve as a major tool in the prevention and treatment of metabolic syndrome and cancer.
Compounds found in green tea, especially EGCG, show significant anti-cancer activity and hold promise as potential anticancer drugs or adjuvants to standard chemotherapy.
2022 International Journal of Molecular Sciences Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer Farhan M
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The study used a combination of epidemiological and laboratory studies to examine the effects of catechins in green tea on combating cancer. The researchers focused their attention on the four main catechin derivatives found in green tea: epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate—the latter found to be most potent. Attention was given to the quantity of hydroxyl groups and the presence of certain structural groups in these compounds, and how these factors affected antioxidant activity.
The study centered around the effects of catechins on tumor survival, proliferation, invasion, angiogenesis, and metastasis. By doing this, the researchers could observe the influence of the identified compounds on the various processes that lead to the development and spread of cancer. The main point of observation was the capacity of catechins to neutralize reactive oxygen species, a key facet in their anti-cancer activity.
The jujube tree bears fruit endowed with substantial nutritional value and contains numerous phytochemical components with reported antioxidant, anti-cancer and neuroprotective properties.
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The research implemented an analysis of the jujube tree, its fruit, and its long history of usage in traditional medicine, focusing primarily on its use in traditional Persian and Chinese medicines. The varied geographical distribution of the tree was studied, especially its presence in tropical and subtropical regions across Europe and Asia. Researchers took into account the tree’s resilience to soil salinity and alkalinity as part of its general characteristics.
The core of the study involved an in-depth investigation into the nutritional composition and pharmacological properties of the jujube fruit. The fruit's contents were categorized into proteins, minerals, vitamins, organic acids, and carbohydrates. Furthermore, a range of phytochemical components such as polyphenols, flavonoids, terpenoids, anthocyanins, alkaloids, and carotenoids were identified.
Research noted both the fruit's nutraceutical and cosmeceutical potential. It also explored the medicinal properties of all elements of the plant, not just the fruit.
The physiological impacts of the jujube were also evaluated across various medical contexts, seeking to understand its impact on different organs and tissues, as well as its influence on various health conditions and concerns. Culminating in the identification of antioxidant, anti-cancer, antimicrobial, neuroprotective, cardioprotective, hepatoprotective properties. Noteworthy, are also its health-promoting effects, with strong references to anti-aging properties.
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