Ureaplasma Urealyticum Infection Contributes to the Development of Pelvic Endometriosis Through Toll-Like Receptor 2

2019 Oct 04   Frontiers in Immunology   Noh EJ, Kim DJ, Lee JY, Park JH, Kim JS, Han JW, et al.

The study demonstrated, using a mouse model of endometriosis, that U. urealyticum infection increased the numbers and sizes of ectopic endometriotic lesions, upregulated the production of inflammatory mediators (IL-6, CXCL1, CCL2), and enhanced expression of adhesion molecules (ICAM-1, VCAM-1) and MMP-2 in PMCs. The inflammatory responses were mediated primarily through TLR2 signaling, and infection-induced pelvic inflammation was proposed to contribute to the initiation and progression of endometriosis.