Investigating the Molecular Mechanism of Xijiao Dihuang Decoction for the Treatment of SLE Based on Network Pharmacology and Molecular Docking Analysis

2022 Jan 20   BioMed Research International   Wei F, Song Y, Gong A, Pan C, Zhuang Y, Zhang X, et al.

The study identified 30 potential active ingredients and 289 potential targets of XJDHT, with 129 intersection targets between XJDHT and SLE. Network topology analysis revealed 23 core targets, including AKT1, TNF, IL6, IL1B, and INS. GO and KEGG enrichment analyses suggested involvement in processes such as the response to lipopolysaccharide and signaling pathways like lipid and atherosclerosis. Molecular docking confirmed strong binding activity between XJDHT compounds and core targets, providing a theoretical basis for further clinical and experimental studies on XJDHT in treating SLE.