Systematic Elaboration of the Pharmacological Targets and Potential Mechanisms of ZhiKe GanCao Decoction for Preventing and Delaying Intervertebral Disc Degeneration

2022 Apr 22   Evidence-Based Complementary and Alternative Medicine   Sun W, Chen Y, Li M

The study identified 154 active ingredients and 133 common genes in the "Intersecting genes-active components" network, with ten key genes (AKT1, TNF, IL6, TP53, IL1B, JUN, CASP3, STAT3, MMP9, and MAPK3). Quercetin, luteolin, and kaempferol were highlighted as the most important core active ingredients. KEGG enrichment analysis revealed pathways related to inflammation, apoptosis, senescence, and autophagy, including the AGE-RAGE signaling pathway, TNF signaling pathway, IL-17 signaling pathway, cellular senescence, apoptosis, and PI3K-Akt signaling pathway.