Multiple Mechanisms of Shenqi Pill in Treating Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking

2022 Jun 26   Evidence-Based Complementary and Alternative Medicine   Tong X, Xu S, Zhai D

The study identified 15 anti-NAFLD bioactive ingredients in SQP, including quercetin, kaempferol, stigmasterol, diosgenin, and tetrahydroalstonine. Key target proteins against NAFLD were AKT1, TNF, MAPK8, IL-6, and VEGFA. The main pathways involved PI3K/Akt signaling, HIF-1 signaling, MAPK signaling, and TNF signaling. Molecular docking predicted binding of quercetin, kaempferol, stigmasterol, diosgenin, and tetrahydroalstonine with AKT1, TNF, and MAPK8, suggesting their potential role in SQP's anti-NAFLD effects.