This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
Insights & Discussion
Needling at the GB20 acupoint in Traditional Chinese Medicine can reverse the expression of certain genes related to axon development and regeneration in optic neuritis.
To explore the molecular mechanisms of GB20 acupoint needling treatment on Optic Neuritis, a common symptom of Multiple Sclerosis, an Experimental Autoimmune Encephalomyelitis (EAE) mouse model with EAE-associated optic neuritis was utilized. Traditional Chinese Medicine practices of needling at the GB20 acupoint and GV16 acupoint control treatment were applied, followed by RNA sequencing of the retinal transcriptome to identify differentially expressed genes.
In the discussion of the results, it was found that of the genes affected by optic neuritis, needling at the GB20 acupoint reversed the expression of 21 genes, including Nr4a3, Sncg, Uchl1, and Tppp3. These genes are particularly involved in axon development and regeneration, suggesting a beneficial effect from GB20 acupoint needling. Moreover, it was discovered that GB20 needling also influenced the circadian rhythm in the mouse retina with optic neuritis. The GV16 was also identified to be an effective control site for GB20 treatment in animal studies.
Discover Related Insights
Acupuncture and moxibustion therapies have shown effectiveness in treating ulcerative colitis according to the summarised-findings of various systematic reviews and meta-analyses.
2024 Heliyon Effects of acupuncture and moxibustion on ulcerative colitis: An overview of systematic reviews Wang D, Wang Q, Wang Y, Li T, Tian M
Systematic Review Acupuncture Moxibustion Ulcerative Colitis
Methodology: This evaluative study used an extensive and systematic methods to search data from seven different databases. The selected data were further refined by using different screening and evaluation frameworks like AMSTAR-2, PRISMA, ROBIS, and GRADE systems. These were used to determine the methodological quality, reporting quality, risk of bias, and the quality of evidence in the selected studies.
Discussion of results: After critical evaluation, the study found ten relevant reviews and analyses that showed potential for acupuncture and moxibustion therapies being effective in ulcerative colitis treatment. However, many the identified studies were reported to have several problems in their overall design and quality of outcomes. The researchers therefore stress caution when interpreting these results due to the lack of high-quality evidence in the existing studies.
Acupuncture may enhance the effectiveness of cognitive-behavioral therapy for people suffering from insomnia and related conditions.
2023 Sleep Medicine Clinics Acupuncture as an Adjunct Treatment to Cognitive-Behavioral Therapy for Insomnia Kutana S, Mao JJ, Garland SN
Theoretical Article Acupuncture Insomnia
The research methodology used in this paper is mainly a theoretical analysis and discussion of the potential synergistic effects of combining cognitive-behavioral therapy for insomnia (CBT-I) and acupuncture. This involves analysis of the current evidence base for the efficacy of acupuncture in treating insomnia and related conditions, along with examination of the practical, logistical, and regulatory aspects of combining these two treatments.
In the discussion of their results, the researchers found that there is a growing body of evidence that supports the potential benefit of acupuncture in treating insomnia and its comorbidities, enhancing the current standard treatment approach of CBT-I. This appears to be an innovative approach that could potentially enhance the treatment effectiveness and outcomes for those struggling with insomnia, though it concurrently raises complex issues in terms of its practical and regulatory implementation.
Acupuncture, either alone or as an adjunct, improved the clinical efficacy and visual acuity of age-related macular degeneration patients, particularly those with dry AMD.
2023 PLOS One Effects of acupuncture on age-related macular degeneration: A systematic review and meta-analysis of randomized controlled trials Sun W, Zhao Y, Liao L, Wang X, Wei Q, Chao G, et al.
Meta-Analysis Acupuncture Age-Related Macular Degeneration
The study conducted a meta-analysis on nine out of 226 articles selected from various databases such as PubMed, Ovid Medline, Embase, Cochrane Library, The Chinese National Knowledge Infrastructure Database, VIP, Wanfang, and SINOMED up until September 4, 2022. Two separate reviewers independently carried out the literature screening and data extraction and used RevMan 5.4 software for the meta-analysis.
In the discussion of the results, it was found that 508 AMD patients (representing a total of 631 eyes), including 360 dry eyes and 271 wet eyes, showed improvement in both clinical efficacy and best-corrected visual acuity after receiving acupuncture treatment. The treatment also led to a reduction in their central macular thickness. However, while the benefits of acupuncture were seen, the quality of evidence supporting these outcomes was judged as ranging from "low" to "very low".
Acupuncture can enhance visual function in people with myopia via particular changes in brain activity.
2023 Frontiers in Integrative Neuroscience The effect of acupuncture at the Taiyang acupoint on visual function and EEG microstates in myopia Su K, Wang L, Wang Z, Ma J, Zhang C, Bi H, et al.
Experimental Study Acupuncture Myopia
In this study, a group of 21 myopic patients received acupuncture at a specific acupoint. To assess the impact of this treatment on their vision, a technique known as contrast sensitivity (CS) was used to analyse vision quality before and after the acupuncture process. At the same time, electroencephalography (EEG) was employed to record changes in brain activity throughout the procedure.
It was observed post-acupuncture that patients' contrast sensitivity was generally better, implying improved visual abilities. Moreover, EEG data divulged certain changes in brain states labelled as 'microstates', particularly a decrease in the contribution of 'microstate C' and a lower transition probability between 'microstate A' and 'microstate C'. Furthermore, analysis showed a negative correlation between the contribution of 'microstate C' and contrast sensitivity. These findings suggest a connection between the enhancement of visual function and specific neurophysiological processes.
Acupuncture combined with moxibustion has shown significant benefits in the treatment of mild to moderate Crohn's disease.
2023 Journal of Pharmacopuncture The Effects of Acupuncture on Crohn’s Disease: a systematic review and meta-analysis Bae JH, Kang SY, You SE, Jeong HI, Jang S, Kim KH
Meta-Analysis Acupuncture Crohn's Disease
In this systematic review, the researchers conducted a comprehensive search of 12 databases for randomized controlled trials on the impact of acupuncture on Crohn's disease. Three independent reviewers assessed the risk of bias for each study. The level of evidence from meta-analyses was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology.
The review included a total of 12 studies. Findings suggest that acupuncture combined with moxibustion, a traditional East Asian treatment involving burning a small bunch of herbs on particular points on the body, had an effect on the treatment outcomes for patients with mild to moderate Crohn's disease when compared to a group given sham acupuncture and sham moxibustion treatments. Notably, findings on the effectiveness of acupuncture treatment only, without the addition of moxibustion, were less clear. It is also important to emphasize that this review was firmly focused on the benefits of the treatment on patients with mild to moderate symptoms of Crohn's disease.
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