Insights & Discussion
Kushen-based traditional Chinese medicine formulations show considerable potential and effectiveness in treating ulcerative colitis with meaningful improvement in clinical remission rate.
In the study, researchers sourced multiple databases, specifically PubMed, EMBASE, Chinese Biomedical Literature database, China National Knowledge Infrastructure database, Chongqing VIP Information database, and Wanfang database, to find articles published from January 2000 to July 2020. These articles focused on randomized controlled trials using Kushen-based traditional Chinese medicine formulations for ulcerative colitis treatment. Additionally, they utilized a network pharmacology approach to discern the potential pathways of Kushen's influence against ulcerative colitis.
Regarding the results, eight randomized controlled trials encompassing a total of 983 subjects were analyzed. When compared to subjects treated with standard therapy, patients who underwent treatment with Kushen-based formulations showed an increased clinical remission rate alongside a decreased incidence of adverse events. A detailed component-target-pathway network associated with Kushen treatment against ulcerative colitis was established. This highlighted five primary components, three primary targets, and one crucial therapeutic pathway.
Discover Related Insights
Acupuncture and moxibustion therapies have shown effectiveness in treating ulcerative colitis according to the summarised-findings of various systematic reviews and meta-analyses.
2024 Heliyon Effects of acupuncture and moxibustion on ulcerative colitis: An overview of systematic reviews Wang D, Wang Q, Wang Y, Li T, Tian M
Systematic Review Acupuncture Moxibustion Ulcerative Colitis
Methodology: This evaluative study used an extensive and systematic methods to search data from seven different databases. The selected data were further refined by using different screening and evaluation frameworks like AMSTAR-2, PRISMA, ROBIS, and GRADE systems. These were used to determine the methodological quality, reporting quality, risk of bias, and the quality of evidence in the selected studies.
Discussion of results: After critical evaluation, the study found ten relevant reviews and analyses that showed potential for acupuncture and moxibustion therapies being effective in ulcerative colitis treatment. However, many the identified studies were reported to have several problems in their overall design and quality of outcomes. The researchers therefore stress caution when interpreting these results due to the lack of high-quality evidence in the existing studies.
Adding Compound Kushen Injection (CKI), a traditional Chinese medicine, to chemotherapy treatment enhanced treatment response and reduced side effects in advanced colorectal cancer patients.
2024 Integrative Cancer Therapies Efficacy and Safety of Compound Kushen Injection for Advanced Colorectal Cancer: A Systematic Review and Meta-Analysis of Randomized Clinical Trials with Trial Sequential Analysis Wu J, Ma X, Wang X, Zhu G, Wang H, Zhang Y, et al.
Meta-Analysis Colorectal Cancer Ku Shen
This study systematically collected data from a myriad of sources including, but not limited to, PubMed, the Cochrane Library, and ClinicalTrials.gov up to April 20, 2024. An assessment tool, ROB2, was used to measure the quality of the included trials, while data analysis was done using Stata 16. Publication bias was evaluated with the funnel plot and Egger's test. To calculate the final required sample size in this meta-analysis and verify whether the results presented a stable conclusion, trial sequential analysis was used.
The data collected from these sixteen trials, consisting of 1378 patients showcased that when compared to chemotherapy alone, the combination of CKI and chemotherapy resulted in improved response rates and enhancement of the patient's performance status. Furthermore, this combination therapy was associated with fewer adverse reactions like leukopenia, thrombocytopenia, gastrointestinal reactions, and liver damage. Patients also exhibited high CD4 ratios and comparatively low CD8 T cell ratios. A subgroup analysis further demonstrated that the response rates improved significantly when CKI was combined with specific chemotherapy regimens. Overall, this data strongly suggests that the addition of CKI to chemotherapy provided statistically significant and clinically relevant improvements in treatment response rates, patient wellbeing, reduction in adverse reactions, and enhanced immune function.
Diverse acupuncture therapies, especially moxibustion, emerged as superior methods for alleviating ulcerative colitis symptoms in clinical practice.
2024 SSRN Electronic Journal Efficacy and Safety of Different Acupuncture Therapies for Patients with Ulcerative Colitis：A Systematic Review And Network Meta-Analysis Zhang X, Yang S, Jin Y, Cheng X, Lu H, Wu H, et al.
Meta-Analysis Acupuncture Moxibustion Ulcerative Colitis
Methodology: The researchers carried out a systematic review and network meta-analysis of clinical efficacy of various acupuncture therapies for ulcerative colitis patients. They accomplished this by sourcing for Clinical Randomized Controlled trial articles from databases such as PubMed, Embase, Cochrane Library, and other data knowledge service platforms, all of which were independently reviewed by two researchers. Several quality assessments were made through Review Manager software, and the meta-analysis was conducted with Stata 16 software. Interventions examined in the analysis included acupuncture, moxibustion, acupoint catgut embedding, and combinations of these therapies with Western medicine.
Discussion of results: 52 articles encompassing 3924 patients participated in randomized control trials. The investigation revealed a range of interventions, including different acupuncture therapies and combinations of these therapies with Western medicine. Namely, moxibustion, either on its own or combined with Western medicine, consistently surfaced as top-ranked for overall effectiveness and specific outcomes. Moreover, moxibustion displayed impressive performance in reducing adverse reactions and recurrence rates. Thus, various acupuncture therapies were confirmed as safe and effective for the treatment of ulcerative colitis, with moxibustion emerging as the most effective.
A combined Mediterranean, low-FODMAP diet along with partial enteral nutrition has shown promise in reducing ulcerative colitis activity and improving patients' quality of life.
2024 Scientific Reports Effectiveness of a novel diet in attenuation of clinical activity of disease in patients with ulcerative colitis: a randomized, clinical trial Narimani B, Sadeghi A, Daryani NE, Shahrokh S, Nilghaz M, Ghods M, et al.
Randomised Controlled Trial Low FODMAP Ulcerative Colitis
In the study, fifty patients with active, mild to moderate ulcerative colitis were randomly allotted one of two diets: a combined Mediterranean, low-FODMAP diet supplemented with partial enteral nutrition, or a standard diet. These diets were implemented for a duration of 6 weeks. Before and after the intervention, various indicators of the patients' conditions were measured. These variables included a disease activity index, the patients' quality of life, and concentrations of various inflammatory and oxidative stress factors in the blood. All of these were measured using tested and trustworthy questionnaires, in conjunction with blood sampling.
The combined diet was found to result in significantly decreased disease activity index values, compared to both the control diet and the baseline data. Simultaneously, patients on the combined diet reported greater enhancements in their quality of life, compared to both the control group and the initial data. Lastly, the serum level of a protein called "high sensitive C-reactive protein," known to be a general marker of inflammation within the body, was found to be reduced in the combined diet group. However, changes in the serum total antioxidant capacity were found to be statistically insignificant across both groups.
Acupoint application has been proven to be a safe and effective method for the treatment of ulcerative colitis.
2023 Medicine Efficacy and safety of acupoint application in the treatment of ulcerative colitis: A systematic review and meta-analysis Tong Y, Yu Y, Yin S, Lin S, Chen Y, Su X
Meta-Analysis Ulcerative Colitis
The methodology incorporated a systematic review of various databases including China National Knowledge Infrastructure, Chinese Biology Medicine, VIP, Wanfang, Embase, PubMed, the Cochrane Library and Web of Science up to July 2022 to find published randomized controlled trials on the use of acupoint application in treating ulcerative colitis. Meta-analysis and trial sequential analysis were then performed on the selected studies.
The results from the 13 analyzed trials involving a total of 878 cases revealed that the use of acupoint application improved the rates of effective clinical comprehensive and syndrome in ulcerative colitis treatment compared to conventional western medicine. The method also showed advantages in increasing interleukin-4 and reducing interferon-gamma. Also noted was that there were no variances seen regarding colonoscopy, pathological examination, and reaction rates when compared with traditional methods. The quality of the evidence used for these conclusions varied, with some being of moderate quality and others deemed low or very low quality.
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