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Pomegranate juice has potential beyond ascorbic acid alone in enhancing iron absorption and assimilation, supporting Ayurveda's proposition of managing iron deficiency anemia with pomegranate.
2020 Plant Foods for Human Nutrition Pomegranate Juice Enhances Iron Dialysability and Assimilation in In-Vitro Cell Free and Cell-Based Models Balasubramani SP, Varghese RK, Vishnuprasad CN, Venkatasubramanian P
Experimental Study Iron Absorption Iron Deficiency Pomegranate
The study applied a cell-free model imitating gastric and intestinal digestive procedures, along with cell-based models (in the form of Caco-2 and HepG2 cells), to evaluate iron dialysability in the presence of pomegranate juice. This method was utilized to observe iron uptake into cells, assessed via cellular ferritin content measures.
Pomegranate juice highly improved iron dialysability in the cell-free model and increased iron uptake and ferritin content in the cells’ models far more than ascorbic acid alone. This result corroborates Ayurveda's claim regarding the beneficial usage of pomegranate in managing iron deficiency anemia, proposing a straightforward remedy to a global health issue. The betterment of iron bioavailability could be due to the synergistic action of various phytochemicals in pomegranate juice, suggesting a multifunctional utility for this natural product.
Pomegranate juice consumption over a short period promotes red blood cell production without significantly changing metabolic health and inflammation markers in healthy individuals.
2017 Experimental and Therapeutic Medicine Effect of pomegranate juice consumption on biochemical parameters and complete blood count Manthou E, Georgakouli K, Deli CK, Sotiropoulos A, Fatouros IG, Kouretas D, et al.
Randomised Controlled Trial Haemoglobin Iron Deficiency Pomegranate
In the methodology of this study, ten healthy subjects (five males and five females averaging 31.8 years of age and weighing an average of 66.2 kg) were split into two groups. One group drank 500 ml of pomegranate juice every day for 14 days, while the other did not. Blood samples were taken from the subjects before and after the experimental period to measure various health markers.
In the discussion of results, it was observed that pomegranate juice intake led to a substantial rise in red blood cell count, hemoglobin levels, and hematocrit levels. However, other complete blood count parameters, and levels of glucose, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and C-reactive protein remained largely unaffected after the juice consumption. This suggests that pomegranate juice only had a substantial effect on increasing erythropoiesis or decreasing degradation in healthy individuals.