Insights & Discussion
The Chinese herbal formula Erxian decoction appears to be more effective than basic supplements in treating osteoporosis.
A systematic review of six databases was conducted, looking for randomized controlled trials using Erxian decoction in osteoporosis treatment. The trials measured a variety of outcomes, including fracture incidents, changes in bone mineral density, improvements in pain symptoms, alterations in bone biochemical markers, quality of life, and adverse reactions. The timeline encompassed all trials conducted up until September 17, 2016, with no restriction on language.
The results from the eight trials involving a total of 644 patients were analysed. Two separate meta-analyses were conducted. The first compared the effectiveness of the decoction to caltrate tablets in improving bone density in the spine and femoral great trochanter. The second meta-analysis evaluated the decoction plus caltrate tablets and calcitriol in improving the bone density of the femoral neck, and the levels of calcium and phosphorus, when compared to calcitriol and caltrate tablets. The most common side effect was minor cases of gastrointestinal symptoms.
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Clinical studies related to breast cancer have revealed that honey is effective in increasing blood cell counts, interleukin-3 levels, and quality of life.
2023 Antioxidants Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer Martiniakova M, Kovacova V, Mondockova V, Zemanova N, Babikova M, Biro R, et al.
Clinical Study Honey Osteoporosis
In relation to breast cancer, in vitro experiments revealed the anti-proliferative and pro-apoptotic impact of honey on breast cancer cells, as well as their increased apoptosis. Animal studies have shown that honey reduces the number, growth rate, volume, and tumor weight. Findings from clinical trials reported its immunomodulatory properties showing that honey is effective in increasing leukocyte and platelet counts, IL-3 levels, and quality of life. In this context, the potential role of honey and its oligosaccharides as prebiotics for specific beneficial bacteria might be examined in future clinical studies.
Preclinical studies related to osteoporosis have reported favorable effects of honey on cortical and trabecular bone microstructure, bone strength, and oxidative stress.
2023 Antioxidants Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer Martiniakova M, Kovacova V, Mondockova V, Zemanova N, Babikova M, Biro R, et al.
Clinical Study Honey Osteoporosis
Honey is able to protect the bone mainly due to antioxidant and anti-inflammatory properties, primarily through its content of polyphenols, which act on several signaling pathways, resulting in anabolic and antiresorptive effects. From the group of polyphenols, the anti-osteoporotic impact of quercetin, kaempferol, and luteolin was recorded. In addition, vitamin D3 and its hydroxyderivatives with antioxidant properties were also detected in honey. Vitamin D3 supplementation was found to have protective effects on the inhibition of bone loss and BMD in both experimental animals and postmenopausal women.
The compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside from chrysanthemum flowers demonstrated superior antioxidant and anti-osteoporosis effects.
2023 Journal of Science and Technology - HaUI Investigate the antioxidant and anti-osteoporosis activities of compounds isolated from chrysanthemum indicum flowers Le The Hoai, Nguyen Thi Huong, Bui Thi Thu Trang
Experimental Study Antioxidant Osteoporosis
The research involved isolating five compounds from Chrysanthemum indicum L flowers: Syringin, Dihydrosyringin, Benzyl-O-β-D- glucopyranoside, -Phenylethoxy-O--D-glucopyranoside, and (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside. The identification and structure determination of these compounds were performed via the interpretation of their 1D - NMR spectra and comparison to established literature. The collected compounds were then assessed for their antioxidative and anti-osteoporosis activities.
During the analysis of results, it was observed that the compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside exhibited significantly higher antioxidant activity and anti-osteoporosis effects compared to the others. It showed a strong capacity for peroxyl radical scavenging, surpassing the protection offered by the standard Trolox. Dihydrosyringin also demonstrated a good reducing capacity, as indicated by its CUPRAC values. Furthermore, (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside displayed strong inhibitory effects on osteoclast differentiation, indicating its potential as an anti-osteoporosis agent.
Soybean intake can potentially reduce risks of several cancers, type 2 diabetes, osteoporosis, and hot flashes, and it may negatively impact some drug treatments and cause allergies.
2023 Journal of Microbiology and Biotechnology Benefits of Soybean in the Era of Precision Medicine: A Review of Clinical Evidence Kang JH, Dong Z, Shin SH
Review Article Breast Cancer Hot Flushes Osteoporosis
This research primarily involves review and analysis of current clinical studies focusing on the benefits and risks of soybean ingredients. The method appears to be a systematic review of various epidemiological studies which were investigating the correlation between soybean consumption and the risk of developing multiple types of cancers including breast, prostate, colorectal, ovarian, and lung cancers. Besides cancer, other common diseases such as type 2 diabetes, osteoporosis, and menopausal symptoms like hot flashes were also investigated. Moreover, any potential adverse effects of soybean, including its possible detrimental impact on certain drug treatments and its allergenicity, were also factors of study in these clinical evidences.
In the discussion of results, the researchers found a significant inverse association between soybean intake and cancer risks, wherein an increase in the consumption of soybean foods was associated with a reduced likelihood of cancer. Besides showing potential anticancer properties, soybean consumption was found inversely correlated with risks of type 2 diabetes. Soy isoflavones, compounds present in soybeans, also showed potential benefits in the management of osteoporosis and hot flashes. On the other hand, the adverse effects of soybean, including interference with certain drug therapies and causing allergies, were also duly noted. Therefore, the research concludes that while soybean promises several significant health benefits, caution should be exercised for individuals under specific drug treatments or with allergies to soy.
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
2023 PharmaNutrition Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits Tan ST, Tan SS, Tan CX
Review Article Cholesterol High Blood Pressure Isoflavone
Methodology: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. It began with a sophisticated multi-database search, featuring resources like Google Scholar, Scopus, and others. This search targeted articles published from 2017 to March 2023 and used specific keywords for accuracy. Forty-three articles were handpicked from this process after excluding reviews, conference reports, duplicates, inaccessible texts, and any non-English publications.
Discussion of Results: A thorough examination of the chosen articles resulted in the conclusion that soy proteins, soy bioactive peptides, and soy isoflavones are typically safe for human consumption. Furthermore, it was found that the consumption of these compounds may have beneficial effects, potentially lowering risk factors for ailments such as osteoporosis, various cancers, hypertension, atherosclerosis, and more.
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