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Alginate, as a treatment option for laryngopharyngeal reflux, is equally effective as proton pump inhibitors and may serve as a potential alternative treatment.
2022 European Archives of Oto-Rhino-Laryngology Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux: a non-inferiority randomized controlled trial Pizzorni N, Ambrogi F, Eplite A, Rama S, Robotti C, Lechien J, et al.
Randomised Controlled Trial Alginate GERD Magnesium
Researchers employed a non-inferiority randomized controlled trial with fifty participants, all of whom exhibited laryngopharyngeal symptoms. They were divided into two treatment groups; one group received the alginate suspension Gastrotuss in three daily doses, while the other was administered Omeprazole once daily. The Reflux Symptom Index and Reflux Finding Score were used to measure the severity of symptoms both before the treatment and after the two-month treatment period.
It was found that both groups had similar Reflux Symptom Index and Reflux Finding Score values initially. After the two-month treatment, both groups demonstrated significant decrease in these indices, suggesting that the symptoms and signs of laryngopharyngeal reflux were significantly reduced, regardless of the treatment given. The difference between the changes in both Reflux Symptom Index and Reflux Finding Score from the two groups was found to be insignificant, thereby indicating that the effectiveness of Alginate is non-inferior to Proton Pump Inhibitors.
Ginger, peppermint and caraway oil combination showed strong effectiveness in managing upper gastrointestinal complaints, with melatonin and marine alginate demonstrating moderate evidence.
2022 Nutrients Effectiveness of Nutritional Ingredients on Upper Gastrointestinal Conditions and Symptoms: A Narrative Review Schulz RM, Ahuja NK, Slavin JL
Review Article Alginate Caraway GERD
The methodology consisted of a literature review of the scientific studies pertaining to nutritional ingredients for upper gastrointestinal relief. The selection was based on recurring mentions within the literature and frequent appearance in consumer products. A predefined search for specific nutritional ingredients and terms related to upper GI health was conducted in five databases - Embase, Medline, Derwent drug file, ToXfile, and PubMed. A manual search was also undertaken for each ingredient to ensure comprehensive review.
The studies that gained inclusion encompassed 16 human clinical trials assessing nine different ingredients. The products investigated were divided into categories, including botanicals - with sub-categories of fiber and combinations, and non-botanical extracts. Several products demonstrated good potential, others showed promising but moderate results, while some had limited support from the scientific research.