Insights & Discussion
Discover Related Insights
Morinda citrifolia root extracts display significant antibacterial activity against various bacteria, with the highest impact against Campylobacter spp.
2024 PLOS One In vitro antibacterial activity of Morinda citrifolia extracts against eight pathogenic bacteria species Obeng-Boateng F, Kpordze SW, Addy F
Antibacterial Campylobacter Noni
The study investigates the antibacterial properties of various forms of Morinda citrifolia (root, leaf, and fruit- fresh, dried, and fermented). These were extracted through distilled water and varied concentrations of ethanol(60%, 80%, 100%). The antibacterial assessments were conducted using the agar well diffusion method, utilizing Ciprofloxacin as a positive control. While all forms of the plant showed some degree of antibacterial performance, the root extracts were found to have the most significant influence.
The analysis of the results reveals a variance in antibacterial activity amongst the different extracts and the concentration of the solvents used. Among the solvents, the 100% ethanol extracts showed the most significant zones of inhibition. Certain bacteria, such as Enterococcus faecium, Campylobacter spp., and Bacillus cereus, were found to be more sensitive to the plant extracts. In contrast, Shigella spp. and Klebsiella spp. demonstrated resistance to most of the extracts. The study concludes a promising potential for antibacterial applications of M. citrifolia extracts.
Noni fruit and its compounds demonstrate significant potential in cancer therapy by inducing apoptosis, arresting cell cycle, inhibiting angiogenesis, and modulating immune system.
2024 Phytotherapy Research Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update Kitic D, Miladinovic B, Randjelovic M, Szopa A, Seidel V, Prasher P, et al.
Systematic Review Anticancer Noni
In this study, a systematic review was put forth to scrutinize the therapeutic effectiveness of Morinda citrifolia L., commonly known as Noni, specifically looking into its effects on various forms of cancer. The review employed an extensive search of various scientific databases to gather relevant literature. This included both in vitro and in vivo studies, as well as clinical trials, specifically focusing on the outcomes of Noni fruit and its phytoconstituents - anthraquinones, flavonoids, sugar derivatives, and neolignans - on cancer. A carefully structured keyword and criteria search ensured a robust collection and analysis of data.
The plethora of studies compiled point out to Noni's complex role in cancer therapy, underlining its various bioactive elements and their methods of activity. Significant anticancer and chemopreventive potential of Noni was observed, establishing it as potentially a safe and effective option in cancer prevention and treatment.
Pomegranate juice consumption appears to somewhat enhance inflammatory status and complete blood count in hospitalized COVID-19 patients.
2023 Complementary Therapies in Medicine Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients: A randomized and placebo-controlled trial Yousefi M, Sadriirani M, Mahmoodi S, Samimi B, Pourmahmoudi A, Hosseinikia M, et al.
Randomised Controlled Trial CRP Inflammation
The study was a randomized, double-blinded placebo-controlled trial involving 48 patients and had two parallel arms. As part of their standard hospital care, patients were either given 500 mL of whole pomegranate juice daily or a placebo for a period of 14 days. The researchers focused on measuring inflammatory indicators and complete blood counts both at the start of the study and at the end of the 14-day intervention period.
Following the 14-day intervention, there was a distinguishable decrease in primary outcomes including inflammatory markers such as C reactive protein, interleukin-6, and erythrocyte sedimentation rate in the group that consumed pomegranate juice as compared to the readings before the intervention. In addition, considerable changes were also observed in secondary outcomes such as neutrophils, lymphocytes, platelets, platelets-to-lymphocyte and neutrophils-to-lymphocyte ratios in the pomegranate juice group compared to the parameters before the intervention. Finally, the mean changes in levels of interleukin-6, white blood cells, neutrophils, lymphocyte, platelets, platelets-to-lymphocyte ratio, blood oxygen saturation and MCV were significantly different between the two groups by the end of intervention, while no significant difference was noted in other blood indices.
Noni fruit juice enhances immune system function, primarily by boosting natural killer cell activity and increasing interferon-gamma production, which promotes phagocytosis.
2023 Journal of Biosciences and Medicines The Influence of Noni Fruit Juice on Immune System Function West BJ, Uwaya A, Isami F, Tomida N, Swartz F, Deng S, et al.
Review Article Antioxidant Immunity Noni
The research was conducted using several human, animal, and in vitro studies to gain insight into the immunomodulatory effects of noni fruit juice. They observed the impact on natural killer cell activity and monitored interferon-gamma production to assess improvements in immune function. Further investigation was carried out to identify how noni influences this process, with a focus on kinase 1/2, protein kinase B, and nuclear factor-kappa-beta signaling. In addition, they carried out trials to evaluate the antioxidant properties of noni juice.
The studies showed that noni juice significantly enhances the immune system's function. This was evidenced by an increase in natural killer cell activity, which likely contributes to improved health outcomes and survival times as seen in previous case reports. Furthermore, they saw an increase in interferon-gamma production, known to boost natural killer cell activity and phagocytosis. They also discovered that noni promotes regulatory cytokine expression, which supports immune response. Additionally, noni juice demonstrated considerable antioxidant properties, implying a positive effect on oxidative status, a key player in immune function.
Acupuncture has shown to be potentially beneficial as an alternate or adjunct therapy for patients with Bell's palsy following recovery from COVID-19.
2022 Journal of Complementary and Alternative Medical Research Can Acupuncture be an Adjunct Therapy for Bell’s palsy Post COVID-19? Acupuncture for Bell’s Palsy: A Review Yepthomi T, Somanadhapai S
Review Article Bell's Palsy
In the methodology utilized for this research, an extensive literature search was carried out by two independent investigators. They used multiple sources including PubMed, MEDLINE, Google scholar, LILACS, and the Cochrane Register of Controlled Trials, from the year 2000 up until 2021. They used the keywords: Bell’s Palsy, covid-19, acupuncture, Mucormycosis, vaccine, and steroids. Selected articles were only those published in English and included full-text. The studies included in the review were all randomized controlled trials which compared acupuncture intervention's clinical effects (used alone or add on) with no treatment.
In terms of results, although the methodological quality of most studies was considered generally low, six randomized controlled trials were found to be satisfactory and included in the study. According to the results across these studies, the groups who received acupuncture treatment reported improved outcomes compared to their baseline or control groups. This was evident as no negative side effects were reported. The review therefore indicates that acupuncture could play a beneficial role in treating patients with Bell's palsy post-recovery from COVID-19, particularly those at risk of mucormycosis and other severe health complications.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.