Insights & Discussion
Noni fruit and its compounds demonstrate significant potential in cancer therapy by inducing apoptosis, arresting cell cycle, inhibiting angiogenesis, and modulating immune system.
In this study, a systematic review was put forth to scrutinize the therapeutic effectiveness of Morinda citrifolia L., commonly known as Noni, specifically looking into its effects on various forms of cancer. The review employed an extensive search of various scientific databases to gather relevant literature. This included both in vitro and in vivo studies, as well as clinical trials, specifically focusing on the outcomes of Noni fruit and its phytoconstituents - anthraquinones, flavonoids, sugar derivatives, and neolignans - on cancer. A carefully structured keyword and criteria search ensured a robust collection and analysis of data.
The plethora of studies compiled point out to Noni's complex role in cancer therapy, underlining its various bioactive elements and their methods of activity. Significant anticancer and chemopreventive potential of Noni was observed, establishing it as potentially a safe and effective option in cancer prevention and treatment.
Discover Related Insights
Noni, a medicinal plant, has illustrated diverse anticancer properties across different cancer models through numerous mechanisms including antitumor and immunomodulatory activities.
2022 Integrative Cancer Therapies Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent Chanthira Kumar H, Lim XY, Mohkiar FH, Suhaimi SN, Mohammad Shafie N, Chin Tan TY
Anticancer Cancer Noni
A systematic review was undertaken to compile scientific evidence on the anticancer properties of Noni. The process involved the use of predefined search terms across five electronic databases - MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. As a result, 51 clinical and preclinical studies, of which 41 were efficacy and 10 safety studies, were used for this review.
The results of this review demonstrated that Noni exhibited various anticancer properties across differing cancer models. These effects were undertaken through multiple mechanisms ranging from antitumor, antiproliferative, and pro-apoptotic to antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. This underscores the potential value of Noni as a medicinal plant in cancer treatment.