Insights & Discussion
Ginger can reduce the direct activation of type 3 and 4 afferent nerve fibers by substances such as bradykinin and sensitization of afferent fibers by prostaglandins and cytokines.
Due to a paucity of well-conducted trials, evidence of the efficacy of Z. officinale to treat pain remains insufficient. However, the available data provide tentative support for the anti-inflammatory role of Z. officinale constituents, which may reduce the subjective experience of pain in some conditions such as osteoarthritis. Further rigorous trials therefore seem to be warranted.
Discover Related Insights
Green tea and its compounds, especially catechins, may potentially prevent and treat osteoarthritis due to their potent antioxidant and anti-inflammatory properties.
2020 Longhua Chinese Medicine The possible role of green tea on osteoarthritis: a narrative report Barbalho SM, Goulart RA, Buglio DS, Araujo AC, Guiguer EL
Review Article Anti-Inflammatory Antioxidant Green Tea
The researchers performed an extensive review exploring the potential impact of green tea and its bioactive compounds, chiefly catechins, on osteoarthritis management. Their focus was on the anti-inflammatory and antioxidant abilities of these compounds. Based on the review, such compounds can quell inflammation by blocking various signaling pathways interconnected with inflammatory processes. Specifically, they have the potential to suppress the expression of several cytokines and enzymes related to inflammation.
In addition, green tea was noted for its property to neutralize free radicals, thus averting the formation of harmful reactive oxygen species and countering oxidative stress. While many conventional, non-surgical osteoarthritis therapies can lead to numerous adverse effects, the current review suggests that green tea could serve as a safer alternative. It may be a promising direction in the prevention and management of this chronic, painful, and inflammatory condition, which touches a significant number of people globally.
Tart cherry juice may lessen inflammation, thus reducing pain in women with osteoarthritis, according to changes noted in specific inflammatory serum biomarkers.
2012 Journal of Food Studies Efficacy of Tart Cherry Juice to Reduce Inflammation Biomarkers among Women with Inflammatory Osteoarthritis (OA) Kuehl KS, Elliot DL, Sleigh AE, Smith JL
Randomised Controlled Trial Anti-Inflammatory Cherry CRP
This study used a randomized, double blind, placebo-controlled trial design, involving twenty women with inflammatory osteoarthritis, aged between 40 to 70 years. The participants were given 10.5 ounce bottles of tart cherry juice or a placebo cherry drink to consume twice daily for a span of 21 consecutive days. Pain was assessed at the start and the end of the intervention period. At these same junctures, blood samples were collected to monitor the influence of the juice on serum biomarkers of inflammation: C-Reactive Protein, Interleukin-6, Interleukin-10, and Tumor Necrosis Factor-alpha.
The results depicted that the group consuming tart cherry juice experienced a significant reduction in the serum biomarker, C-Reactive Protein, an indication of lowered inflammation. This is suggestive that tart cherry juice could be an efficient way of reducing inflammation, and subsequently, the pain experienced by women suffering from osteoarthritis.
the principal active ingredient for these effects being gingerols, which has anti-prostaglandin effects
— 31 Aug 2021