High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions

2018 Oct 15   Frontiers in Endocrinology   Elibol Birsen, Kilic Ulkan

Recent studies have shown that age-related diseases or endocrine system dysfunctions are associated with an increase in SIRT1 expression levels, but with a decrease in their activity. The oxidative stress produced during these processes may lead to compensatory or protective increase in the SIRT1 expression to deal with the decline of the SIRT1 activity.