Citrus Peel Flavonoids as Potential Cancer Prevention Agents

2020 May   Current Developments in Nutrition   Nooshin Koolaji, Balakrishnan Shammugasamy, Aaron Schindeler, Qihan Dong, Fariba Dehghani, Peter Valtchev

Overall, citrus flavonoids act not only as free radical scavengers but also as modulators of several key molecular events implicated in cell survival and apoptosis. Flavonoids exhibit a remarkable spectrum of biological activities including anti-inflammatory, anticancer, antiproliferation, antiangiogenesis, antioxidant, cell cycle regulation, and antimetastasis effects.

Review Article
Submitted by Jinnan C. 5 Sep 2021 - Added by 23 Sep 2021

Insights & Discussion

Citrus peel flavonoids exhibit a remarkable spectrum of biological activities including anti-inflammatory, anticancer, antiproliferation, antiangiogenesis, antioxidant, cell cycle regulation, and antimetastasis effects.

This review has summarized a selection of the key preclinical and clinical studies that show an anticancer utility for citrus-derived flavonoids. This property is linked to the chemical structures of flavonoids, which can dramatically affect a range of molecular and cellular mechanisms for inhibiting cancer initiation and progression. Overall, citrus flavonoids act not only as free radical scavengers but also as modulators of several key molecular events implicated in cell survival and apoptosis.

— Jinnan C. 23 Sep 2021

Citrus peels are rich in polyphenolic compounds, which are secondary plant metabolites with diverse and essential biological functions
— 23 Sep 2021

Sign In

Sign in to comment on this article.

Sign In Create Account