Insights & Discussion
There is low quality evidence that bitter melon adjunct preparations improved glycemic control in type 2 diabetes mellitus patients.
Ten studies of type 2 diabetes mellitus (n = 1045) were included in the meta-analysis. They had 4–16 weeks follow up and overall moderate to high risk of bias. Compared to placebo, M. charantia monoherbal formulation significantly reduces FPG, PPG and HBA1c with mean difference of − 0.72 mmol/L, (95% CI: −1.33, −0.12), I2 = 14%, − 1.43 mmol/L, (95% CI: −2.18, −0.67), I2 = 0, − 0.26%, (95% CI: -0.49, −0.03), I2 = 0 respectively. M. charantia also lowered FPG in prediabetes (mean difference −0.31 mmol/L, n = 52); the evidence was downgraded to low quality because the study had unclear risk of bias and inadequate sample size. No serious adverse effects were reported.
M. charantia adjunct preparations improved glycemic control in T2DM patients. However, this conclusion is based on low to very low quality evidences for the primary outcomes and sparse data for several safety outcomes, thus, warrant further research. Particularly needed are the researches that focus on standardizing M. charantia formulation and determine its efficacy and safety in clinical trials with adequate sample size, designed with random sequence generation, allocation concealment of intervention and blinding of both research personnel and participants.
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Consuming “Sneznik-1/79” mineral water significantly improves intestinal health and reduces cholesterol in type 2 diabetes patients.
2023 Heliyon The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus Jovicic N, Andjic M, Novakovic J, Jeremic N, Zivkovic V, Srejovic I, et al.
Cohort Study Gut Microbiota Intestinal Peristalsis Mineral Water
The study involved 60 patients with confirmed Type 2 Diabetes, who drank “Sneznik-1/79” mineral water from Serbia daily for 28 days. Researchers conducted standard biochemical tests, including glucose level, lipid profile, and stool analysis. Additionally, blood samples were taken to assess the impact of the water on oxidative stress markers.
Post consumption of “Sneznik-1/79” water, a substantial decrease in total cholesterol levels was noted. Notably, all patients experienced regular daily bowel movements, indicating improved intestinal peristalsis. Half of the participants showed elimination of dysbiosis. Furthermore, there was an increase in antioxidants like superoxide dismutase and reduced glutathione, suggesting enhanced antioxidant capacity. The study highlights “Sneznik-1/79” water as a potential complementary treatment for improving gut health and reducing cholesterol in Type 2 Diabetes patients.
Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases.
2023 Frontiers in Nutrition Eating more sardines instead of fish oil supplementation: Beyond omega-3 polyunsaturated fatty acids, a matrix of nutrients with cardiovascular benefits Santos HO, May TL, Bueno AA
Review Article Cardiovascular Disease Cholesterol High Blood Pressure
The abstract primarily acknowledges the importance of Omega-3 polyunsaturated fatty acids with respect to managing diseases related to heart health and metabolism, for instance, type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. However, these fatty acids are not the sole beneficial component of sardines. Minerals including but not limited to calcium, potassium, and magnesium as well as substances like taurine and arginine found in sardines have a significant role in controlling mild inflammation and oxidative stress which are usually present in cardiovascular diseases and hemodynamic dysfunction.
The results discussed in the abstract suggest a positive correlation between consumption of sardines and potential cardiometabolic benefits. By considering the dose-response relationship effects, a pragmatic approach towards consumption of nutrients was suggested. The intake of sardines was seen not only as a means of Omega-3 supplementation but also as a comprehensive approach to enhancing cardiovascular health. The abstract concludes with an emphasis on the many beneficial nutrients found in sardines besides Omega-3, underlining the need to shift the focus from synthetic supplementation to natural dietary improvement.
Almond consumption has beneficial impacts on cardiovascular diseases, diabetes, obesity, and it can improve cognitive performance and protect against skin aging.
2023 Nutrire Nutritional and health-beneficial values of almond nuts consumption Ouzir M
Review Article Almond Cognitive Function Obesity
The methodology employed in this study included analyzing a range of clinical studies centered on the health benefits linked to the consumption of sweet almond nuts. Various health outcomes correlated with almond consumption were investigated such as body weight, food intake, blood pressure, blood lipid composition, glucose and insulin levels, oxidative status, liver enzymes, and some inflammation biomarkers.
The discussion of the results reveals that almond consumption has been found to create favorable alteration in aspects like body weight, food intake, blood pressure, blood lipid composition, glucose, and insulin levels, as well as oxidative status, liver enzymes, and inflammation biomarkers. These findings highlight the beneficial impact of almonds on multiple health issues including cardiovascular diseases, diabetes, and obesity. Additionally, the consumption of almonds has been associated with improved cognitive performance and protection against skin photodamage and aging.
Soybean intake can potentially reduce risks of several cancers, type 2 diabetes, osteoporosis, and hot flashes, and it may negatively impact some drug treatments and cause allergies.
2023 Journal of Microbiology and Biotechnology Benefits of Soybean in the Era of Precision Medicine: A Review of Clinical Evidence Kang JH, Dong Z, Shin SH
Review Article Breast Cancer Hot Flushes Soybean
This research primarily involves review and analysis of current clinical studies focusing on the benefits and risks of soybean ingredients. The method appears to be a systematic review of various epidemiological studies which were investigating the correlation between soybean consumption and the risk of developing multiple types of cancers including breast, prostate, colorectal, ovarian, and lung cancers. Besides cancer, other common diseases such as type 2 diabetes, osteoporosis, and menopausal symptoms like hot flashes were also investigated. Moreover, any potential adverse effects of soybean, including its possible detrimental impact on certain drug treatments and its allergenicity, were also factors of study in these clinical evidences.
In the discussion of results, the researchers found a significant inverse association between soybean intake and cancer risks, wherein an increase in the consumption of soybean foods was associated with a reduced likelihood of cancer. Besides showing potential anticancer properties, soybean consumption was found inversely correlated with risks of type 2 diabetes. Soy isoflavones, compounds present in soybeans, also showed potential benefits in the management of osteoporosis and hot flashes. On the other hand, the adverse effects of soybean, including interference with certain drug therapies and causing allergies, were also duly noted. Therefore, the research concludes that while soybean promises several significant health benefits, caution should be exercised for individuals under specific drug treatments or with allergies to soy.
Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions.
2023 PharmaNutrition Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits Tan ST, Tan SS, Tan CX
Review Article Cholesterol High Blood Pressure Isoflavone
Methodology: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. It began with a sophisticated multi-database search, featuring resources like Google Scholar, Scopus, and others. This search targeted articles published from 2017 to March 2023 and used specific keywords for accuracy. Forty-three articles were handpicked from this process after excluding reviews, conference reports, duplicates, inaccessible texts, and any non-English publications.
Discussion of Results: A thorough examination of the chosen articles resulted in the conclusion that soy proteins, soy bioactive peptides, and soy isoflavones are typically safe for human consumption. Furthermore, it was found that the consumption of these compounds may have beneficial effects, potentially lowering risk factors for ailments such as osteoporosis, various cancers, hypertension, atherosclerosis, and more.
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