Insights & Discussion
Acupuncture was superior to either sham acupuncture or medication (including Itopride, Mosapride, and Domperidone) in relieving the major symptoms of functional dyspepsia.
Acupuncture therapy (including manual and electroacupuncture) achieved statistically significant effect in improving the overall symptoms and quality of life of functional dyspepsia patients comparing to sham acupuncture and is superior to medication (prokinetic agents) in ameliorating the major symptoms of functional dyspepsia (postprandial fullness and early satiation).
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Xiao Yao San can improve symptoms and reduce recurrence rates in patients with disorders of gut-brain interaction.
2022 Frontiers in Pharmacology Efficacy and Safety of Chinese Herbal Medicine Xiao Yao San in Functional Gastrointestinal Disorders: A meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials Liu Q, Shi Z, Zhang T, Jiang T, Luo X, Su X, et al.
Systematic Review Constipation Functional gastrointestinal disorders Irritable Bowel Syndrome
The paper's methodology involved a meta-analysis of randomized controlled trials found in seven databases, up until November 22, 2021. The trials, which totaled 48 all together, were included to determine the efficacy of Xiao-Yao-San in treating disorders of gut-brain interaction (previously known as functional gastrointestinal disorders). A range of measures, including therapeutic efficacy, symptom score, Self-Rating Anxiety Scale score, Self-Rating Depression Scale score, and the recurrence rate, were analysed using both random-effects and fixed-effects models, as well as trial sequential analysis.
In terms of results, Xiao-Yao-San showed a marked improvement in the effective rate of managing disorders of gut-brain interaction compared to western drugs, both when used alone and in combination with western medicine. The paper also found the treatment notably reduced symptom scores, anxiety scores, and depression scores for patients with the disorder. Further, instances of recurrence were also reduced. Overall, Xiao-Yao-San was well tolerated and no serious adverse events were reported in any of the trials included in this analysis.
Chinese herbal medicine shows promising and safe outcomes in relieving functional dyspepsia symptoms and associated psychological disorders.
2022 Frontiers in Neuroscience Chinese Herbal Medicine for Functional Dyspepsia With Psychological Disorders: A Systematic Review and Meta-Analysis Luo X, Wang L, Fang S, Qing X, Jiang T, Yang Y, et al.
Systematic Review Anxiety Chinese Herbal Medicine Depression
The methodology for this research involved a comprehensive search across various libraries and databases, such as PubMed, Embase, Cochrane Library, Web of Science, and various Chinese data sources, seeking randomized controlled trials where functional dyspepsia was treated with Chinese herbal medicine. The aim was to assess the efficacy and safety of this type of treatment for functional dyspepsia. Two researchers independently conducted each stage of the process, from searching the sources, screening the documents, extracting data, and assessing risk biases within the included studies. They used RevMan 5.4 software to do a meta-analysis of the selected research materials.
The discussion of their findings showed that treatment with Chinese herbal medicine significantly alleviated the symptoms of functional dyspepsia, compared to both a placebo group and a group treated with traditional prokinetic agents and flupentixol melitracen. Patients treated with Chinese herbal medicine reported higher total effective rates and lower total symptom scores, along with smaller depression and anxiety scores. The symptoms of functional dyspepsia, in this case, were improved more successfully with Chinese herbal medicine than with other treatment types, without any significant adverse reactions.
Positive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life.
2020 World Journal of Gastroenterology Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review Guo Y, Wei W, Chen JD
GERD
In this systematic review, we pooled randomized controlled trials with mechanistic investigations of acupuncture or electroacupuncture in improving dyspeptic symptoms, and illustrated the existing results that may provide potential explanations for the therapeutic effects. The findings of included studies in this review suggest that acupuncture and electroacupuncture can improve gastric motility and accommodation, regulate gastrointestinal hormones and mental status, and alter certain central and autonomic functions in patients with functional dyspepsia. However, due to limitations in the included articles, high-quality studies with well-planned designs and multiregional investigations are necessary to provide more convincing and credible evidence.
A combination of peppermint oil and caraway oil is an effective and safe short-term treatment for functional dyspepsia.
2019 Evidence-Based Complementary and Alternative Medicine A Combination of Peppermint Oil and Caraway Oil for the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis Juanjuan Li, Lin Lv, Jiaqi Zhang, Lin Xu, Enjin Zeng, Zedan Zhang, et al.
Systematic Review Caraway Digestive Health Peppermint
It is the first attempt to generate RCT data of peppermint oil and caraway oil (POCO) for the treatment of functional dyspepsia. In this meta-analysis, we evaluated the efficacy and safety of POCO based on five RCTs with 578 patients. The results demonstrated that POCO can significantly improve global symptoms of FD, with an NNT of 3 when data from four studies were pooled. The positive and significant efficacy in terms of improvement in epigastric pain was also shown between the two studies. Moreover, the available data have found that the safety profile of POCO is similar to placebo.
The strength of our findings is that no significant heterogeneity was detected across the studies. Besides, study designs of the included trials were fairly similar and the duration of treatment was identical. We used rigorous methodology as follows and believe that the results reflect the best available current evidence. Firstly, our literature search was comprehensive including all RCTs regardless of publication type and language. Besides, we adopted the intention-to-treat analysis on all data to enhance the robustness of the results.
The consumption of kiwifruit with a meal can increase the rate and extent of the hydrolysis of protein.
2014 Nutrients Variation in Gastric pH May Determine Kiwifruit’s Effect on Functional GI Disorder: An in Vitro Study Donaldson B, Rush E, Young O, Winger R
Network Pharmacology Kiwifruit
This in vitro study has shown that in elevated gastric pH conditions, such as may present with compromised gastric function, the addition of kiwifruit protease more than doubled the rate of hydrolysis of meat protein. This novel finding supports the hypothesis that consumption of kiwifruit with a meal can increase the rate and extent of the hydrolysis of protein.
Evidence is also provided that when the added acid concentration decreased from 0.074 M to 0.022 M (HCl), pepsin activity reduced by 50% and kiwifruit activity increased by 300%.
This evidence indicates that kiwifruit may exert its influence on digestion by increasing the extent of protein digestion in the gastric medium when the secretion of pepsin and/or hydrochloric acid is less than optimal. It is reported [12] in a study of 365 healthy subjects, average fasting gastric pH was 2.16 ± 0.11 for men and 2.79 ± 0.18 for women, but in another study of 79 healthy elderly people [13], 11% of the participants recorded fasting gastric pH > 5.0 throughout the study.
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