This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
Insights & Discussion
When combined, Silibinin and Pu-erh tea extract prove more effective in preventing non-alcoholic fatty liver disease than when used individually.
The research used obese mice (ob/ob) and fed them a high-fat diet along with the oral administration of Silibinin, Pu-erh tea extract, or both, over a six-week period. Concurrently, lean mice were used as a control group, consuming a regular diet. The blood chemical index and histopathological evaluations were analyzed to determine the effects of Silibinin and Pu-erh tea extract on the mice, particularly in terms of weight, blood lipid levels, fat metabolism, and inflammatory response.
The results showcased that in comparison to the group of mice suffering from non-alcoholic fatty liver disease, the groups which received either Pu-erh tea extract, Silibinin, or a combination of both exhibited significant reductions in weight and blood lipid levels. Furthermore, both Silibinin and Pu-erh tea extract, whether used alone or in tandem, were found to improve fat metabolism and decrease the inflammatory response to a certain extent. The combined group, however, displayed the strongest efficacy in adjusting fat metabolism and inhibiting oxidative stress. They also revealed the drugs' ability to inhibit fat synthesis and improve cholesterol homeostasis by regulating the expression of specific genes. The combined effect was superior to that of individual usage.
Discover Related Insights
Pu-erh tea was found to lower triglyceride and total cholesterol levels more significantly than green, oolong, or black teas.
2019 Nature Communications Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism Huang, F., Zheng, X., Ma, X. et al.
Experimental Study Cholesterol Digestive Health Fatty Liver Disease
Comparative studies using rodents treated with Pu-erh tea, green tea, and black tea provided supporting evidence that fully fermented Pu-erh tea is more effective in causing hypolipidemic and hypocholesterolemic effects compared to other partially fermented and non-fermented teas.
Pu-erh tea water extracts could potentially enhance liver health and reduce oxidative stress in rats on a high-fat diet.
2016 Food Science and Human Wellness Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet Jingjing Su, Xueqing Wang, Wenjun Song, Xiaoli Bai, Changwen Li
Experimental Study Fatty Liver Disease Pu-Erh Tea
In this study, fifty SD rats were split into five distinct groups and subjected to a high-fat diet. Their body weights were noted daily. Researches measured the serum levels of malondialdehyde (MDA), glucose, catalysts such as alanine aminotransferase and aspartate aminotransferase, nitric oxide synthase, and pyruvate kinase. Besides, hepatic glycogen levels were assessed, along with the activity of liver enzymes like total superoxide dismutase, catalase, and glutathione peroxidase. These measurements were consistently undertaken for a duration of 12 weeks.
The findings showcased a decrease in the body weight and fat index of rats after the administration of Pu-erh tea extract. The reduction in body weight and fat index was accompanied by a decrease in malondialdehyde and nitric oxide synthase levels. Interestingly, there was also a noticeable increase in the activities of hepatic total superoxide dismutase, catalase, and glutathione peroxidase. These findings suggest that the Pu-erh extract might reduce the oxidant stress state, inhabit lipid peroxidation, and protect liver health in rats. Simultaneously, the extracts seemed to boost the production of liver glycogen, enhance the activity of pyruvate kinase, and decrease glucose levels, thereby possibly safeguarding the liver from diseases linked to Type II Diabetes.