Insights & Discussion
Acupuncture may have a positive impact on clinical pregnancy rate and live birth rate in women undergoing in vitro fertilization (IVF), although the results are limited by the heterogeneity of the current evidence.
This study aimed to assess the efficacy of acupuncture on embryo transfer in women undergoing in vitro fertilization (IVF). A total of 49 randomized controlled trials (RCTs) involving 9422 women were analyzed. The results indicated that acupuncture had a significant positive impact on the clinical pregnancy rate (CPR) and live birth rate (LBR) compared to the control groups (odds ratio [OR]=1.65 for CPR, 1.34 for LBR). Subgroup analyses showed that traditional acupuncture was more beneficial for women aged < 35 years, those receiving ≥ 3 sessions, and those with lower baseline CPR rates in the control group. However, significant heterogeneity was observed among the studies. In conclusion, while there were some benefits of acupuncture in improving CPR and LBR in IVF, the results should be interpreted with caution due to the variability in the current evidence.
Discover Related Insights
Acupuncture appears to be beneficial to women with poor ovarian reserve or with previous unsuccessful attempts of in vitro fertilization with embryo transfer.
2019 Journal of Gynecology Obstetrics and Human Reproduction The effects of acupuncture on pregnancy outcomes of in vitro fertilization with embryo transfer: An interdisciplinary systematic review Gu, Y.-E., Zhang, X., Zhang, Q., et al.
Systematic Review IVF
The present systematic review is designed to summarize the evidence concerning the effect of acupuncture on pregnancy outcomes in vitro fertilization with embryo transfer (IVF-ET). We searched MEDLINE, the Wanfang Database, the China Academic Journal Electronic Full-text Database in the China National Knowledge Infrastructure, and the Index to Chinese Periodical Literature. Randomized controlled trials with intervention groups using acupuncture and control groups consisting of no acupuncture or sham (placebo) acupuncture in IVF-ET treatment were selected. Study characteristics were examined from these studies and an intention-to-treat approach was used to extract outcome data from each study. In total, 31 articles including 4450 women passed our selection criteria. The legitimacy, characteristics, and IVF outcomes of the included trials were summarized. Additional Traditional Chinese Medicine (TCM) theory-based, standardized, large-size, randomized, and multicenter trials are necessary prior to any conclusions being drawn on whether TCM can improve IVF outcomes.
Acupuncture may have a significant effect on clinical pregnancy rates, independent of comparator group, when used in women who have had multiple previous IVF cycles, or where there was a low baseline pregnancy rate.
2019 Reproductive BioMedicine Online Acupuncture performed around the time of embryo transfer: a systematic review and meta-analysis Smith, C. A., Armour, M., Shewamene, Z., et al.
Systematic Review Embryo Transfer Female Fertility IVF
Evidence suggests acupuncture may be effective when compared with no adjunctive treatment, with increased clinical pregnancies and live births, but is not an efficacious treatment when compared with sham controls. Future research should focus on different dosing acupuncture regimens, and exploration of the components of acupuncture that are contributing to improved reproductive outcomes. Increased understanding of these components may have broader application to the care and treatment modalities provided to women undergoing IVF. Further exploration of the effects of acupuncture for women with poorer IVF outcomes is warranted.
Acupuncture performed on the day of embryo transfer has a significant effect on embryo implantation, however, a negative one.
2018 JBRA Assisted Reproduction Does acupuncture the day of embryo transfer affect the clinical pregnancy rate? Systematic review and meta-analysis Schwarze, J.-E., Ceroni, J. P., Ortega-Hrepich, C., et al.
Systematic Review Embryo Transfer IVF
According to our findings, physicians should encourage their patients to avoid undergoing acupuncture on the day of ET, since it diminishes the chances of getting pregnant. It still has to be elucidated the mechanisms by which acupuncture negatively affects embryo implantation.
In conclusion, acupuncture performed on the day of ET has a significant effect on embryo implantation, however, a negative one. Therefore, clinicians should encourage their patients to avoid this technique the day of ET.
Despite some indications of improved clinical pregnancy rates, the overall effectiveness of acupuncture as a treatment for couples with subfertility undergoing assisted reproduction therapy remains inconclusive and requires further high-quality research.
2018 Evidence-Based Complementary and Alternative Medicine Effects of Acupuncture on the Outcomes of Assisted Reproductive Technology: An Overview of Systematic Reviews Xi, J., Chen, H., Peng, Z., et al.
Systematic Review Female Fertility IVF Stress
This abstract summarizes the findings of systematic reviews and meta-analyses assessing the effectiveness of acupuncture in treating couples with subfertility undergoing assisted reproduction therapy (ART). The review included eleven studies published between 2009 and 2017 and examined primary outcomes of live birth and clinical pregnancy, and secondary outcomes of ongoing pregnancy, miscarriage, and adverse events. The results suggest that acupuncture may improve the clinical pregnancy rate in ART patients. However, there was insufficient evidence to support its impact on live birth rate, ongoing pregnancy rates, or miscarriage, mainly due to the low quality of the included studies. The overall effectiveness of acupuncture in treating subfertility during ART remains uncertain, emphasizing the need for further high-quality research and well-reported trials.
Acupuncture improves the clinical pregnancy rate among women undergoing IVF and the IVF outcome results were significantly superior in the acupuncture group when acupuncture was conducted during controlled ovarian hyperstimulation.
2016 Archives of Gynecology and Obstetrics Therapeutic effect of acupuncture on the outcomes of in vitro fertilization: a systematic review and meta-analysis Qian, Y., Xia, X.-R., Ochin, H., et al.
Systematic Review IVF
When the studies were restricted to Asian or non-Asian area patients, compared with traditional acupuncture and other methods, electrical acupuncture yielded better IVF outcomes. Optimal positive effects could be expected using acupuncture in IVF during controlled ovarian hyperstimulation, especially in Asian area. However, as a limitation of this review, most of the included studies did not mention the number of embryos transferred.
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Review(s) Completed, Editorial Evaluation Pending, as of 20 Oct 2021.
—Ve-Vinn L 22 Oct 2021