Melatonin
Recent Insights
Recent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.
Honey Melatonin Serotonin
Acupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion.
Melatonin
Consumption of tart cherry juice can increase exogenous melatonin that is beneficial in improving sleep duration and quality and might be of benefit in managing disturbed sleep.
Cherry Melatonin Sleep
Tart cherry juice blend yielded modest improvements in sleep for older adults with insomnia, exhibiting effects similar to or better than natural products like valerian and melatonin.
Cherry Insomnia Melatonin
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Research Articles
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Acute effects of fresh versus dried Hayward green kiwifruit on sleep quality, mood, and sleep-related urinary metabolites in healthy young men with good and poor sleep quality
2023 Mar 14 Frontiers in Nutrition Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Randomised Controlled Trial Serotonin Kiwifruit SleepConsumption of fresh or dried kiwifruit in the evening improves aspects of sleep quality and mood, potentially mediated through changes in serotonin metabolism.
Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey
2022 Sep 30 Melatonin Research Kim TK, Fabisiak A, Brzeminski P, Reiter RJ, Slominski AT
Review Article Honey Serotonin Melatonin Vitamin DRecent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.
Acute Evening Consumption of Green Kiwifruit in Young Men Enhances Waking Alertness, Mood and Increases 5-Hydroxyindoleacetic Acid in Urine
2022 May 09 NSNZ 2021 Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Randomised Controlled Trial Mood Sleep Kiwifruit SerotoninConsuming New Zealand green kiwifruit improves sleep quality, mood, and increases the concentration of serotonin metabolites.
Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway
2021 Feb Sleep Medicine Reviews Huiberts LM, Smolders KCHJ
These studies revealed mixed results for both sleep and mood. The findings were interpreted based on the previously proposed serotonergic pathway of vitamin D. Implications and challenges for future research regarding the timing of blood sampling, timing and dosage of supplement intake and investigating the response dynamics are discussed.
Clinical Study Randomised Controlled Trial Serotonin SleepEffect of Acupuncture on Pregnancy-Related Insomnia and Melatonin: A Single-Blinded, Randomized, Placebo-Controlled Trial
2020 May 13 Nature and Science of Sleep Foroughinia S, Hessami K, Asadi N, Foroughinia L, Hadianfard M, Hajihosseini A, et al.
Randomised Controlled Trial MelatoninAcupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Consumption of fresh or dried kiwifruit in the evening improves aspects of sleep quality and mood, potentially mediated through changes in serotonin metabolism.
2023 Frontiers in Nutrition Acute effects of fresh versus dried Hayward green kiwifruit on sleep quality, mood, and sleep-related urinary metabolites in healthy young men with good and poor sleep quality Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Randomised Controlled Trial Kiwifruit Serotonin Sleep
A randomized, single-blind crossover study involving 24 men with varying sleep quality levels was conducted. Participants were provided with one of three treatments during their standard evening meal at home: the flesh of two fresh green kiwifruits, dried green kiwifruit powder (with skin and equivalent to the dry matter of two fresh kiwifruits) mixed with water, or a water control. Various factors were evaluated including subjective and objective sleep quality, mood, and urine concentration of several compounds including the serotonin metabolite 5-HIAA, vitamin C, and B-vitamins.
Findings indicated that regardless of sleep quality group, dried kiwifruit consumption was associated with an improvement in morning sleepiness, alertness upon waking, and vigor as compared to the control. Both fresh and dried kiwifruit treatments suggested an improvement in self-esteem and overall mood disturbance. Increase in the urinary concentration of serotonin metabolite was observed with both kiwifruit treatments. Amongst poor sleepers, ease of awakening was notably improved after the intake of dried kiwifruit and showed signs of improvement with fresh kiwifruit. For good sleepers, there seemed to be an improvement in getting to sleep with fresh kiwifruit. Poor sleepers were found to have lower quantities of certain B-vitamins compared to good sleepers. Thus, both dried and fresh kiwifruit consumption with a standard evening meal showed a positive impact on sleep quality and mood.
Recent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.
2022 Melatonin Research Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey Kim TK, Fabisiak A, Brzeminski P, Reiter RJ, Slominski AT
Review Article Honey Serotonin Vitamin D
The identification of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey aligns with their presence in insects and plants. Serotonin and melatonin, integral to tryptophan metabolism, serve diverse roles as hormones, neurotransmitters, and antioxidants. Dopamine and tryptamine, essential neurotransmitters, have broad significance across species. The detection of these molecules in honey, a widely consumed health-promoting substance, enhances its beneficial effects on human health.
The findings highlight the multifaceted composition of honey, encompassing compounds with recognized roles in neurotransmission, antioxidant activity, and hormonal regulation. The presence of these molecules not only broadens honey's spectrum of health benefits for humans but also implies their significance in the intricate physiology of social insects, influencing bee development and colony functions. The co-detection of these compounds with vitamin D3 derivatives further underscores the interconnectedness of honey with insect and plant biology, shedding light on potential synergies that contribute to the diverse positive effects of honey on human health.
Consuming New Zealand green kiwifruit improves sleep quality, mood, and increases the concentration of serotonin metabolites.
2022 NSNZ 2021 Acute Evening Consumption of Green Kiwifruit in Young Men Enhances Waking Alertness, Mood and Increases 5-Hydroxyindoleacetic Acid in Urine Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Randomised Controlled Trial Kiwifruit Mood Serotonin
A total of 24 men, ranging in age and with varying sleep quality were selected for the study, in a single-blind crossover design, which was randomized. Participants were provided three treatments on separate occasions, each differing by 6-8 days: consumption of two fresh kiwifruits, ingesting green kiwifruit powder mixed with water equivalent to two fresh kiwifruits, or a simple water control.
Poor sleepers noted that they woke up more easily after consuming dried kiwifruit, with a similar but less pronounced trend observed when they consumed fresh kiwifruit. Conversely, good sleepers showed a trend towards better sleep initiation with fresh kiwifruit, but not with the dried kiwifruit. Independent of the participants' sleep quality, both fresh and dried kiwifruit largely improved mood and self-esteem. Consumption of dried kiwifruit significantly elevated morning alertness, post-wakening behaviour, and vigour. Both forms of kiwifruit ingestion led to higher urinary concentrations of the serotonin metabolite known as 5-HIAA.
Acupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion.
2020 Nature and Science of Sleep Effect of Acupuncture on Pregnancy-Related Insomnia and Melatonin: A Single-Blinded, Randomized, Placebo-Controlled Trial Foroughinia S, Hessami K, Asadi N, Foroughinia L, Hadianfard M, Hajihosseini A, et al.
Randomised Controlled Trial
Fifty-five of 72 participants completed the study. There was no statistically significant difference regarding PSQI score and 6-sulfatoxymelatonin level between intervention and control groups at the baseline. At the end of the study period, treatment with acupuncture significantly improved the PSQI score with a large effect size of 3.7, as well as 6-sulfatoxymelatonin level with a medium effect size of 0.6 as compared to the control group. No adverse effects were noted during acupuncture sessions and follow-up visits.
Acupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion, and could be recommended as a low-cost and low-risk alternative treatment to pharmacological therapies.
The clinical efficacy of acupuncture appeared to be supported by evidence obtained from basic neuroendocrinological studies.
2013 International Review of Neurobiology Acupuncture for the treatment of insomnia Kaicun Zhao
Systematic Review Insomnia
A number of studies have demonstrated that acupuncture may modulate a wide range of neuroendocrinological factors following stimulation of acupoints. Evidence has suggested that the clinical efficacy of acupuncture in treatment of insomnia is potentially mediated by a variety of neurotransmitters including norepinephrine, melatonin, gamma-aminobutyric acid, and β-endorphin. However, due to the complexity, these findings are far from conclusive. More research is necessary. More rigors methodology and integrated approach to evaluate both clinical and basic research evidence are required for future studies.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey
2022 Sep 30 Melatonin Research Kim TK, Fabisiak A, Brzeminski P, Reiter RJ, Slominski AT
Review Article Honey Serotonin Melatonin Vitamin DRecent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.
Acupuncture for the treatment of insomnia
2013 Jan International Review of Neurobiology Kaicun Zhao
Systematic Review InsomniaThe clinical efficacy of acupuncture appeared to be supported by evidence obtained from basic neuroendocrinological studies.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Acute effects of fresh versus dried Hayward green kiwifruit on sleep quality, mood, and sleep-related urinary metabolites in healthy young men with good and poor sleep quality
2023 Mar 14 Frontiers in Nutrition Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Randomised Controlled Trial Serotonin Kiwifruit SleepConsumption of fresh or dried kiwifruit in the evening improves aspects of sleep quality and mood, potentially mediated through changes in serotonin metabolism.
Acute Evening Consumption of Green Kiwifruit in Young Men Enhances Waking Alertness, Mood and Increases 5-Hydroxyindoleacetic Acid in Urine
2022 May 09 NSNZ 2021 Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Randomised Controlled Trial Mood Sleep Kiwifruit SerotoninConsuming New Zealand green kiwifruit improves sleep quality, mood, and increases the concentration of serotonin metabolites.
Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway
2021 Feb Sleep Medicine Reviews Huiberts LM, Smolders KCHJ
These studies revealed mixed results for both sleep and mood. The findings were interpreted based on the previously proposed serotonergic pathway of vitamin D. Implications and challenges for future research regarding the timing of blood sampling, timing and dosage of supplement intake and investigating the response dynamics are discussed.
Clinical Study Randomised Controlled Trial Serotonin SleepEffect of Acupuncture on Pregnancy-Related Insomnia and Melatonin: A Single-Blinded, Randomized, Placebo-Controlled Trial
2020 May 13 Nature and Science of Sleep Foroughinia S, Hessami K, Asadi N, Foroughinia L, Hadianfard M, Hajihosseini A, et al.
Randomised Controlled Trial MelatoninAcupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion.
Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality
2011 Oct 30 European Journal of Nutrition Howatson G, Bell PG, Tallent J, Middleton B, McHugh MP, Ellis J
Randomised Controlled Trial Sleep Cherry MelatoninConsumption of tart cherry juice can increase exogenous melatonin that is beneficial in improving sleep duration and quality and might be of benefit in managing disturbed sleep.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Randomised Controlled Trial
Consumption of fresh or dried kiwifruit in the evening improves aspects of sleep quality and mood, potentially mediated through changes in serotonin metabolism.
Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Review Article
Recent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits.
Kim TK, Fabisiak A, Brzeminski P, Reiter RJ, Slominski AT
Randomised Controlled Trial
Consuming New Zealand green kiwifruit improves sleep quality, mood, and increases the concentration of serotonin metabolites.
Kanon AP, Giezenaar C, Roy NC, McNabb WC, Henare SJ
Randomised Controlled Trial
Acupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion.
Foroughinia S, Hessami K, Asadi N, Foroughinia L, Hadianfard M, Hajihosseini A, Pirasteh N, Vossoughi M, Vafaei H, Faraji A, Kasraeian M, Doroudchi M, Rafiee Monjezi M, Roozmeh S, Bazrafshan K.
Systematic Review
The clinical efficacy of acupuncture appeared to be supported by evidence obtained from basic neuroendocrinological studies.
Kaicun Zhao
Randomised Controlled Trial
Consumption of tart cherry juice can increase exogenous melatonin that is beneficial in improving sleep duration and quality and might be of benefit in managing disturbed sleep.
Howatson G, Bell PG, Tallent J, Middleton B, McHugh MP, Ellis J
Randomised Controlled Trial
Tart cherry juice blend yielded modest improvements in sleep for older adults with insomnia, exhibiting effects similar to or better than natural products like valerian and melatonin.
Pigeon WR, Carr M, Gorman C, Perlis ML
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Melatonin" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Melatonin" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Melatonin" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Randomised Controlled Trial published in 2023 in the journal Frontiers in Nutrition found that Consumption of fresh or dried kiwifruit in the evening improves aspects of sleep quality and mood, potentially mediated through changes in serotonin metabolism. A randomized, single-blind crossover study involving 24 men with varying sleep quality levels was conducted. Participants were provided with one of three treatments during their standard evening meal at home: the flesh of two fresh green kiwifruits, dried green kiwifruit powder (with skin and equivalent to the dry matter of two fresh kiwifruits) mixed with water, or a water control. Various factors were evaluated including subjective and objective sleep quality, mood, and urine concentration of several compounds including the serotonin metabolite 5-HIAA, vitamin C, and B-vitamins. Findings indicated that regardless of sleep quality group, dried kiwifruit consumption was associated with an improvement in morning sleepiness, alertness upon waking, and vigor as compared to the control. Both fresh and dried kiwifruit treatments suggested an improvement in self-esteem and overall mood disturbance. Increase in the urinary concentration of serotonin metabolite was observed with both kiwifruit treatments. Amongst poor sleepers, ease of awakening was notably improved after the intake of dried kiwifruit and showed signs of improvement with fresh kiwifruit. For good sleepers, there seemed to be an improvement in getting to sleep with fresh kiwifruit. Poor sleepers were found to have lower quantities of certain B-vitamins compared to good sleepers. Thus, both dried and fresh kiwifruit consumption with a standard evening meal showed a positive impact on sleep quality and mood.
A Review Article published in 2022 in the journal Melatonin Research found that Recent revelations of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey expand its health benefits. The identification of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK, AMK, and vitamin D3 derivatives in honey aligns with their presence in insects and plants. Serotonin and melatonin, integral to tryptophan metabolism, serve diverse roles as hormones, neurotransmitters, and antioxidants. Dopamine and tryptamine, essential neurotransmitters, have broad significance across species. The detection of these molecules in honey, a widely consumed health-promoting substance, enhances its beneficial effects on human health. The findings highlight the multifaceted composition of honey, encompassing compounds with recognized roles in neurotransmission, antioxidant activity, and hormonal regulation. The presence of these molecules not only broadens honey's spectrum of health benefits for humans but also implies their significance in the intricate physiology of social insects, influencing bee development and colony functions. The co-detection of these compounds with vitamin D3 derivatives further underscores the interconnectedness of honey with insect and plant biology, shedding light on potential synergies that contribute to the diverse positive effects of honey on human health.
A Randomised Controlled Trial published in 2022 in the journal NSNZ 2021 found that Consuming New Zealand green kiwifruit improves sleep quality, mood, and increases the concentration of serotonin metabolites. A total of 24 men, ranging in age and with varying sleep quality were selected for the study, in a single-blind crossover design, which was randomized. Participants were provided three treatments on separate occasions, each differing by 6-8 days: consumption of two fresh kiwifruits, ingesting green kiwifruit powder mixed with water equivalent to two fresh kiwifruits, or a simple water control. Poor sleepers noted that they woke up more easily after consuming dried kiwifruit, with a similar but less pronounced trend observed when they consumed fresh kiwifruit. Conversely, good sleepers showed a trend towards better sleep initiation with fresh kiwifruit, but not with the dried kiwifruit. Independent of the participants' sleep quality, both fresh and dried kiwifruit largely improved mood and self-esteem. Consumption of dried kiwifruit significantly elevated morning alertness, post-wakening behaviour, and vigour. Both forms of kiwifruit ingestion led to higher urinary concentrations of the serotonin metabolite known as 5-HIAA.
A Randomised Controlled Trial published in 2020 in the journal Nature and Science of Sleep found that Acupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion. Fifty-five of 72 participants completed the study. There was no statistically significant difference regarding PSQI score and 6-sulfatoxymelatonin level between intervention and control groups at the baseline. At the end of the study period, treatment with acupuncture significantly improved the PSQI score with a large effect size of 3.7, as well as 6-sulfatoxymelatonin level with a medium effect size of 0.6 as compared to the control group. No adverse effects were noted during acupuncture sessions and follow-up visits. Acupuncture was shown to significantly improve the sleep quality in pregnant women, possibly through increasing melatonin secretion, and could be recommended as a low-cost and low-risk alternative treatment to pharmacological therapies.
A Systematic Review published in 2013 in the journal International Review of Neurobiology found that The clinical efficacy of acupuncture appeared to be supported by evidence obtained from basic neuroendocrinological studies. A number of studies have demonstrated that acupuncture may modulate a wide range of neuroendocrinological factors following stimulation of acupoints. Evidence has suggested that the clinical efficacy of acupuncture in treatment of insomnia is potentially mediated by a variety of neurotransmitters including norepinephrine, melatonin, gamma-aminobutyric acid, and β-endorphin. However, due to the complexity, these findings are far from conclusive. More research is necessary. More rigors methodology and integrated approach to evaluate both clinical and basic research evidence are required for future studies.
A Randomised Controlled Trial published in 2011 in the journal European Journal of Nutrition found that Consumption of tart cherry juice can increase exogenous melatonin that is beneficial in improving sleep duration and quality and might be of benefit in managing disturbed sleep. Total melatonin content was significantly elevated (P < 0.05) in the cherry juice group, whilst no differences were shown between baseline and placebo trials. There were significant increases in time in bed, total sleep time and sleep efficiency total (P < 0.05) with cherry juice supplementation. Although there was no difference in timing of the melatonin circardian rhythm, there was a trend to a higher mesor and amplitude.
A Randomised Controlled Trial published in 2010 in the journal Journal of Medicinal Food found that Tart cherry juice blend yielded modest improvements in sleep for older adults with insomnia, exhibiting effects similar to or better than natural products like valerian and melatonin. In the pilot study, 15 older adults who were suffering from chronic insomnia but were otherwise healthy participated in a randomized, double-blind, crossover design. The study lasted for 6 weeks, with each participant receiving both the proprietary tart cherry juice blend and a placebo for 2 weeks with a 2-week washout period between the two treatments. Sleep continuity and insomnia severity were evaluated by analyzing 2-week mean values derived from daily sleep diaries and the Insomnia Severity Index respectively. The tart cherry juice blend was found to bring significant improvements in all assessed sleep variables before and after treatment. These improvements were particularly noticed in reducing insomnia severity, specifically the minutes awake after sleep onset, compared to placebo. Sleep latency, total sleep time, or sleep efficiency didn't show any notable improvements compared to placebo. The benefits of the tart cherry juice on sleep for older adults with insomnia were in the range of effect sizes seen in studies using valerian or melatonin, which are the most commonly studied natural products for insomnia. But these effects were considerably less than evidence-based insomnia treatments such as hypnotic agents and cognitive-behavioral therapies.
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