Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
How to submit an article:
- Registered users can submit any published journal article that has a unique DOI (Digital Object Identifier) name or link to Research Hub.
- For example, you can paste the full DOI link:
https://doi.org/10.1109/5.771073
or just the DOI name: 10.1109/5.771073
into the field above and click submit.
- The person who is first to submit a valid article to Research Hub will forever be credited for it, and every article submission earns you +6 Research Points.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Pomegranate fruit extract significantly enhances cartilage gene expression and chondrogenesis in human adipose-derived stem cells compared to Avocado/Soybean Unsaponifiable.
Network Pharmacology Avocado Pomegranate
Human adipose-derived stem cells were first isolated, expanded in monolayer culture, and identified, and then seeded on fibrin scaffolds. These cell-impregnated scaffolds were divided into 4 groups: a control group, an Avocado/Soybean unsaponifiable (ASU) group, a Pomegranate Fruit extract (PFE) group, and a mixed ASU/PFE group. Each group was subjected to induction for two weeks with the corresponding substances, except the control group which only received chondrogenic medium.
The levels of cell viability, cartilage gene expression, matrix staining density, and collagen type II proteins in the PFE samples were found to be noticeably greater than other groups. Histological assessments further highlighted higher chondrogenic centers in the PFE group. This indicates that PFE significantly enhances chondrogenesis and cartilage gene expression in these cells, suggesting potential use in cartilage tissue engineering.
View Article
A dietary supplement Avocado/Soybean Unsaponifiables aids in treating Osteoarthritis by preventing cartilage degradation and promoting cartilage repair, thereby reducing pain and enhancing joint functionality.
Review Article Avocado Avocado-Soybean Unsaponifiables Osteoarthritis
Avocado/Soybean Unsaponifiables was studied for its effects on Osteoarthritis. The methodology highlighted its functions, which include inhibiting the release and activity of molecules and pathways that are implicated in OA, as well as those that prevent cartilage degradation. These functions are principally through the prohibition of matrix metalloproteinases and the increase of tissue inhibitors of the catabolic enzymes in question. Additionally, ASU was found to inhibit fibrinolysis by stimulating the expression of plasminogen activator inhibitor. Moreover, its anabolic properties were credited with promoting cartilage repair by stimulating collagen and aggrecan synthesis while inhibiting inflammatory cytokines.
ASU's chondroprotective effects were noted as well; these effects are brought about by correcting growth factor abnormalities, and by simultaneously increasing Transforming Growth Factor-Beta in synovial fluid while decreasing vascular endothelial growth factor. Additionally, it was observed to inhibit cholesterol absorption and biosynthesis, which further contribute to its beneficial role by moderating reactive oxygen species pathology in chondrocytes.
Results indicated that the dietary supplement has significant therapeutic value for those suffering from Osteoarthritis. It reduces pain and stiffness while improving joint function, resulting in less dependency on painkillers. It was found that ASU's preventative measures towards cartilage degradation and its promotion of cartilage repair play essential roles in its efficiency as a treatment for OA.
View Article
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Chinese Medicine Research Hub
Network Pharmacology
Pomegranate fruit extract significantly enhances cartilage gene expression and chondrogenesis in human adipose-derived stem cells compared to Avocado/Soybean Unsaponifiable.
2020 Research in Pharmaceutical Sciences Chondrogenic activity of two herbal products; pomegranate fruit extract and avocado/soybean unsaponifiable
Bahramian H, Teimourinejad A, Hashemibeni B, Salehi H, Mostafavi FS, Kazemi M
Chinese Medicine Research Hub
Review Article
A dietary supplement Avocado/Soybean Unsaponifiables aids in treating Osteoarthritis by preventing cartilage degradation and promoting cartilage repair, thereby reducing pain and enhancing joint functionality.
2014 CARTILAGE Management of Osteoarthritis with Avocado/Soybean Unsaponifiables
Christiansen BA, Bhatti S, Goudarzi R, Emami S
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Articular Cartilage" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Articular Cartilage" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Articular Cartilage" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Network Pharmacology published in 2020 in the journal Research in Pharmaceutical Sciences found that Pomegranate fruit extract significantly enhances cartilage gene expression and chondrogenesis in human adipose-derived stem cells compared to Avocado/Soybean Unsaponifiable. Human adipose-derived stem cells were first isolated, expanded in monolayer culture, and identified, and then seeded on fibrin scaffolds. These cell-impregnated scaffolds were divided into 4 groups: a control group, an Avocado/Soybean unsaponifiable (ASU) group, a Pomegranate Fruit extract (PFE) group, and a mixed ASU/PFE group. Each group was subjected to induction for two weeks with the corresponding substances, except the control group which only received chondrogenic medium.
The levels of cell viability, cartilage gene expression, matrix staining density, and collagen type II proteins in the PFE samples were found to be noticeably greater than other groups. Histological assessments further highlighted higher chondrogenic centers in the PFE group. This indicates that PFE significantly enhances chondrogenesis and cartilage gene expression in these cells, suggesting potential use in cartilage tissue engineering.
A Review Article published in 2014 in the journal CARTILAGE found that A dietary supplement Avocado/Soybean Unsaponifiables aids in treating Osteoarthritis by preventing cartilage degradation and promoting cartilage repair, thereby reducing pain and enhancing joint functionality. Avocado/Soybean Unsaponifiables was studied for its effects on Osteoarthritis. The methodology highlighted its functions, which include inhibiting the release and activity of molecules and pathways that are implicated in OA, as well as those that prevent cartilage degradation. These functions are principally through the prohibition of matrix metalloproteinases and the increase of tissue inhibitors of the catabolic enzymes in question. Additionally, ASU was found to inhibit fibrinolysis by stimulating the expression of plasminogen activator inhibitor. Moreover, its anabolic properties were credited with promoting cartilage repair by stimulating collagen and aggrecan synthesis while inhibiting inflammatory cytokines.
ASU's chondroprotective effects were noted as well; these effects are brought about by correcting growth factor abnormalities, and by simultaneously increasing Transforming Growth Factor-Beta in synovial fluid while decreasing vascular endothelial growth factor. Additionally, it was observed to inhibit cholesterol absorption and biosynthesis, which further contribute to its beneficial role by moderating reactive oxygen species pathology in chondrocytes.
Results indicated that the dietary supplement has significant therapeutic value for those suffering from Osteoarthritis. It reduces pain and stiffness while improving joint function, resulting in less dependency on painkillers. It was found that ASU's preventative measures towards cartilage degradation and its promotion of cartilage repair play essential roles in its efficiency as a treatment for OA.