Liver Enzymes
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Effects of olive oil on hepatic steatosis and liver enzymes: A systematic review
2023 Oct Journal of Functional Foods Ma Y, Ding X, Gu J, Zhou S, Jiang Y
The systematic review concludes that olive oil, used for eating or cooking in randomized controlled trials, demonstrated significant reductions in hepatic steatosis grading through ultrasound and decreases in aspartate transaminase and alanine transaminase levels, suggesting promise in ameliorating hepatic steatosis. However, further investigations are needed to explore the potential effects of different olive oil types or olive polyphenols on chronic liver ailments.
Systematic Review Randomised Controlled Trial
What is the influence of cinnamon supplementation on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials
2021 Jul Phytotherapy Research Mousavi SM, Jayedi A, Bagheri A, Zargarzadeh N, Wong A, Persad E, et al.
This study highlighted the effectiveness of cinnamon in patients with type 2 diabetes and liver enzymes levels.
Systematic Review Meta-Analysis
Efficacy of Hijamat (wet cupping therapy) in Iranian patients with nonalcoholic fatty liver disease: a controlled clinical trial
2020 Apr 9 Turkish Journal of Medical Sciences Bashiri H, Bozorgomid A, Shojaeimotlagh V.
Randomised Controlled Trial
Green tea (Camellia sinensis) for the prevention of cancer
2020 Mar 02 Cochrane Database of Systematic Reviews Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, et al.
Systematic Review Meta-AnalysisGreen tea, containing antioxidative catechins, may possess some beneficial effects in reducing the risk of specific types of cancer.
Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials
2020 Feb 18 Phytotherapy Research Mahmoodi M, Hosseini R, Kazemi A, Ofori‐Asenso R, Mazidi M, Mazloomi SM
Systematic ReviewGreen tea influences liver enzymes differently based on an individual's health status, reducing levels in patients with Nonalcoholic Fatty Liver Disease, but slightly increasing levels in healthy subjects.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Green tea, containing antioxidative catechins, may possess some beneficial effects in reducing the risk of specific types of cancer.
2020 Cochrane Database of Systematic Reviews Green tea (Camellia sinensis) for the prevention of cancer Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, et al.
Systematic Review
The study team performed an extensive review of 142 completed and 2 ongoing studies up to January 2019. These studies encompassed all types of epidemiological studies: experimental (randomised controlled trials) and nonexperimental (observational studies with both cohort and case-control design) that looked into the association of green tea consumption with cancer risk or quality of life, or both. Data extraction and methodological quality assessment of these studies were performed independently by two or more review authors. These efforts were organized and the results summarized according to the type of cancer diagnosis.
The data was sourced from CENTRAL, MEDLINE, Embase, ClinicalTrials.gov, and referenced lists of earlier reviews and included studies. The studies focused on investigating the links between cancer incidence and mortality rates, safety data, quality of life, and green tea consumption.
Numerous studies came with a high degree of methodological quality, based on 'Risk of bias' assessment. The placebos in 11 studies involving a total of 1795 participants were green tea extracts. On another note, the studies indicated some side effects linked to high intakes of green tea with more than a million participants undertaking the non-experimental studies.
Despite inconclusive evidence, experimental and nonexperimental epidemiological studies suggested potential beneficial effects of green tea consumption on the overall risk of cancer or on certain types of cancer. Variations of the beneficial effects of green tea were observable across different cancer types, indicating a decrease in rate ratios (RR) in the highest category of green tea consumption versus the lowest. A detailed analysis based on study design exhibited conflicting results for some types of cancers, showing an increased RR in cohort studies and a decreased or no difference in RR in case-control studies. However, the overall interpretability of these RR estimates was limited by methodological issues, such as low study numbers and inconsistencies with cohort study results. Lastly, it's important to note that the majority of included studies were conducted within populations with a high intake of green tea, mainly Asian, thus limiting the general applicability of the findings to other populations.
Green tea influences liver enzymes differently based on an individual's health status, reducing levels in patients with Nonalcoholic Fatty Liver Disease, but slightly increasing levels in healthy subjects.
2020 Phytotherapy Research Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials Mahmoodi M, Hosseini R, Kazemi A, Ofori‐Asenso R, Mazidi M, Mazloomi SM
Systematic Review
The researchers initiated a comprehensive review and analysis of randomized clinical trials relating to green tea supplementation's effects on liver enzymes. This analysis included forms of green tea supplementation, such as catechin. The information to support this examination was sourced from four medical and health databases and included all trials examining the influence of green tea or its derivatives on specific liver enzymes, including Alanine Transaminase, Aspartate Aminotransferase, Alkaline Phosphatase, and Bilirubin. Altogether, fifteen trials were considered for inclusion in this research.
The study found that while the overall effect of green tea on liver enzymes was nonsignificant, further analysis showed that the impact of green tea on liver enzymes varies depending on an individual's health status. Notably, the use of green tea reduced liver enzyme levels in participants diagnosed with Nonalcoholic Fatty Liver Disease. However, in contrast, a small but statistically significant increase in liver enzyme levels was observed in healthy subjects. These findings suggest that the therapeutic potential of green tea may differ significantly based on an individual's health condition.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Effects of olive oil on hepatic steatosis and liver enzymes: A systematic review
2023 Oct Journal of Functional Foods Ma Y, Ding X, Gu J, Zhou S, Jiang Y
The systematic review concludes that olive oil, used for eating or cooking in randomized controlled trials, demonstrated significant reductions in hepatic steatosis grading through ultrasound and decreases in aspartate transaminase and alanine transaminase levels, suggesting promise in ameliorating hepatic steatosis. However, further investigations are needed to explore the potential effects of different olive oil types or olive polyphenols on chronic liver ailments.
Systematic Review Randomised Controlled TrialWhat is the influence of cinnamon supplementation on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials
2021 Jul Phytotherapy Research Mousavi SM, Jayedi A, Bagheri A, Zargarzadeh N, Wong A, Persad E, et al.
This study highlighted the effectiveness of cinnamon in patients with type 2 diabetes and liver enzymes levels.
Systematic Review Meta-AnalysisGreen tea (Camellia sinensis) for the prevention of cancer
2020 Mar 02 Cochrane Database of Systematic Reviews Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, et al.
Systematic Review Meta-AnalysisGreen tea, containing antioxidative catechins, may possess some beneficial effects in reducing the risk of specific types of cancer.
Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials
2020 Feb 18 Phytotherapy Research Mahmoodi M, Hosseini R, Kazemi A, Ofori‐Asenso R, Mazidi M, Mazloomi SM
Systematic ReviewGreen tea influences liver enzymes differently based on an individual's health status, reducing levels in patients with Nonalcoholic Fatty Liver Disease, but slightly increasing levels in healthy subjects.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Effects of olive oil on hepatic steatosis and liver enzymes: A systematic review
2023 Oct Journal of Functional Foods Ma Y, Ding X, Gu J, Zhou S, Jiang Y
The systematic review concludes that olive oil, used for eating or cooking in randomized controlled trials, demonstrated significant reductions in hepatic steatosis grading through ultrasound and decreases in aspartate transaminase and alanine transaminase levels, suggesting promise in ameliorating hepatic steatosis. However, further investigations are needed to explore the potential effects of different olive oil types or olive polyphenols on chronic liver ailments.
Systematic Review Randomised Controlled TrialEfficacy of Hijamat (wet cupping therapy) in Iranian patients with nonalcoholic fatty liver disease: a controlled clinical trial
2020 Apr 9 Turkish Journal of Medical Sciences Bashiri H, Bozorgomid A, Shojaeimotlagh V.
Randomised Controlled TrialStudies have shown a strong relationship between the level of ferritin and the severity of NAFLD. —Jinnan C 3 Oct 2021
Presentation Slides
Green tea, containing antioxidative catechins, may possess some beneficial effects in reducing the risk of specific types of cancer.
Green tea influences liver enzymes differently based on an individual's health status, reducing levels in patients with Nonalcoholic Fatty Liver Disease, but slightly increasing levels in healthy subjects.
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Studies have shown a strong relationship between the level of ferritin and the severity of NAFLD. —Jinnan C 3 Oct 2021