Sedative-Hypnotic

Effects of Green Kiwifruit Peel Extract on Sleep-Wake Profiles in Mice: A Polysomnographic Study Based on Electroencephalogram and Electromyogram Recordings

2022 Nov 09   Nutrients   Kim D, Yoon M, Kim S, Um MY, Cho S

Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach

2020 Nov 24   Scientific Reports   Guo J, Lou MP, Hu LL, Zhang X

BXHP contains a large number of bioactive compounds with different pharmacological properties. Additionally, the present study showed that the sedative-hypnotic effects of BXHP in patients with SD primarily operate via reductions in inflammation and the mediation of immune and CNS neurotransmitters that regulate multiple targets and pathways.

Targets and underlying mechanisms related to the sedative and hypnotic activities of saponin extracts from semen Ziziphus jujube

2020 Jan   Food & Function   Shen CY, Wan L, Zhu JJ, Jiang JG

Both SZJ-I and SZJ-II demonstrated significant sedative-hypnotic activities, as evidenced by shortened immobility time and potentiation of sodium pentobarbital-induced sleep. SZJ-II, with a higher saponin content, exhibited greater potency. SZJ-I and SZJ-II also protected against PCPA-induced neuropathological damages in the brain and modulated neurotransmitter levels (5-HT, dopamine, noradrenaline, glutamate), inflammatory markers (IL-6, IL-1β), and other signaling molecules (nitric oxide, prostaglandin D2) in plasma. Furthermore, SZJ-I and SZJ-II differentially regulated the expression of various receptors and enzymes in the hypothalamus and hippocampus, suggesting multiple mechanisms contributing to their sedative-hypnotic effects.

Chinese medicines with sedative–hypnotic effects and their active components

2016 Oct   Sleep Medicine Reviews   Shi MM, Piao JH, Xu XL, Zhu L, Yang L, Lin FL, et al.

The study concludes that active ingredients from TCM, including alkaloids, terpenoids, volatile oils, flavonoids, lignanoids and coumarins, saponins, and others, exhibit sedative-hypnotic effects. Current research on TCM's treatment of insomnia is discussed, covering aspects such as active ingredients, sources, experimental models and methods, results, and mechanisms. Additionally, Chinese compound prescriptions derived from various single herbs with sedative-hypnotic effects are introduced, and the acting pathways of TCM are explored in terms of regulating central neurotransmitters, influencing sleep-related cytokines, and improving the structure of the central nervous system.

Chinese medicines with sedative–hypnotic effects and their active components

2016 Oct   Sleep Medicine Reviews   Shi MM, Piao JH, Xu XL, Zhu L, Yang L, Lin FL, et al.

The study concludes that active ingredients from TCM, including alkaloids, terpenoids, volatile oils, flavonoids, lignanoids and coumarins, saponins, and others, exhibit sedative-hypnotic effects. Current research on TCM's treatment of insomnia is discussed, covering aspects such as active ingredients, sources, experimental models and methods, results, and mechanisms. Additionally, Chinese compound prescriptions derived from various single herbs with sedative-hypnotic effects are introduced, and the acting pathways of TCM are explored in terms of regulating central neurotransmitters, influencing sleep-related cytokines, and improving the structure of the central nervous system.