Heme-Iron

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Chinese Medicine Research Hub

Randomised Controlled Trial

Healthy individuals, including those with low iron stores, show reduced nonheme-iron absorption after iron supplementation, leading to larger iron stores that are sustained over time.

2000 The American Journal of Clinical Nutrition Adaptation in iron absorption: iron supplementation reduces nonheme-iron but not heme-iron absorption from food
Roughead ZK, Hunt JR

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Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Heme-Iron" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Heme-Iron" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Heme-Iron" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Randomised Controlled Trial published in 2000 in the journal The American Journal of Clinical Nutrition found that Healthy individuals, including those with low iron stores, show reduced nonheme-iron absorption after iron supplementation, leading to larger iron stores that are sustained over time. This research was conducted via a randomized, placebo-controlled trial with 57 healthy volunteers (comprising of men and women). The participants' absorption of heme and nonheme iron was measured both prior and subsequent to a 12-week course of iron supplementation achieved through the provision of 50mg iron everyday as ferrous sulphate. Alongside, serum and fecal ferritin were observed during the supplementation period and for six months thereafter. In the initial phase, both heme and nonheme iron absorption had an inverse relation with serum ferritin concentration. With the passage of the 12 week period of iron supplementation, participants, even those with serum ferritin less than 21 microg/L, showed evidence of absorbing less nonheme iron from their diet, but no such change was observed with respect to heme iron from a beef-based meal. Serum ferritin concentration was higher after the supplementation period than after placebo, and this increase remained for more than half a year, barring individuals with low iron stores, in whom the serum ferritin levels returned to their initial numbers within three months. A 2.5-fold increase in fecal ferritin excretion was noted during the supplementation. It becomes evident from these findings that even people with low iron stores adapt by lowering their nonheme iron absorption from food in response to iron supplementation. Despite this adaptation, iron stores appeared to be greater after iron supplementation when compared to placebo, and the difference was sustained across the board, except in the case of people with the lowest iron stores.

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