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In women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones.
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A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial
2022 Nov 29 Frontiers in Nutrition Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, et al.
Randomised Controlled Trial Cinnamon Testosterone Metabolic Syndrome FSH Ginger PCOS Insulin Resistance Metformin Ceylon Cinnamon LHIn women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones.
Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats
2022 Sep 22 Antioxidants Kamal DAM, Ibrahim SF, Ugusman A, Mokhtar MH
Network Pharmacology Animal Study PCOS Honey AntioxidantKelulut honey, either alone or in combination with metformin or clomiphene, can alleviate oxidative stress and reproductive and metabolic abnormalities in rats with polycystic ovary syndrome.
Acupuncture combined with metformin versus metformin alone to improve pregnancy rate in polycystic ovary syndrome: A systematic review and meta-analysis
2022 Aug 29 Frontiers in Endocrinology Chen X, Lan Y, Yang L, Liu Y, Li H, Zhu X, et al.
Systematic Review Meta-Analysis PregnancyPCOS patients suggests that combining acupuncture with metformin might enhance pregnancy and ovulation rates, as well as improve insulin resistance.
Effects of Bu Shen Hua Zhuo formula on the LPS/TLR4 pathway and gut microbiota in rats with letrozole-induced polycystic ovary syndrome
2022 Aug 09 Frontiers in Endocrinology Wang Y, Xiao H, Liu Y, Tong Q, Yu Y, Qi B, et al.
The results showed that BSHZF administration was associated with a decrease in body weight, fasting blood glucose, fasting insulin, and testosterone and changes in ovarian morphology in PCOS-model rats. Therefore, the beneficial effects of BSHZF on PCOS pathogenesis are associated with its ability to normalize gut microbiota function and inhibit PCOS-related inflammation.
Animal Study Bu Shen Hua ZhuoThe comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial
2019 Mar 11 Journal of Obstetrics and Gynaecology Mokaberinejad R, Rampisheh Z, Aliasl J, Akhtari E.
The present study concludes that fennel seed infusion plus a dry cupping therapy is effective and safe in reducing the days between two menstrual periods and manages oligomenorrhoea.
Randomised Controlled Trial PCOS CuppingResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
In women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones.
2022 Frontiers in Nutrition A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, et al.
Randomised Controlled Trial Ceylon Cinnamon Cinnamon FSH
In the methodology of the study, 100 women diagnosed with polycystic ovary syndrome were divided into four groups. Each group received a different treatment: cinnamon, ginger, metformin, or placebo. The dosage for these treatments was 500 mg, three times a day, administered over a period of 8 weeks. The participants' sex hormones, weight revelations, along with glycemic and lipid markers were monitored before and after this period. Several participants were disqualified because of unspecified factors, resulting in a final sample size of 83.
In terms of results, all groups saw a decrease in weight and body mass index. The metformin and cinnamon groups specifically had notably decreases in their insulin resistance, meaning that these treatments were effective in improving metabolic health. Additionally, the ginger group experienced a reduction in follicle-stimulating hormone and luteinizing hormone levels unlike the other groups. Testosterone levels were lowered in the metformin and cinnamon groups, but no significant changes in dehydroepiandrosterone were observed in any of the groups. These results indicate the potential use of cinnamon and ginger as alternative treatments in managing polycystic ovary syndrome.
Kelulut honey, either alone or in combination with metformin or clomiphene, can alleviate oxidative stress and reproductive and metabolic abnormalities in rats with polycystic ovary syndrome.
2022 Antioxidants Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats Kamal DAM, Ibrahim SF, Ugusman A, Mokhtar MH
Network Pharmacology Antioxidant Honey PCOS
To examine the effects of Kelulut honey (KH), metformin, and clomiphene on polycystic ovary syndrome (PCOS), female Sprague-Dawley rats were treated with letrozole to stimulate symptoms of PCOS. The rats were then split up into six groups, each group undergoing a different kind of treatment for a period of 35 days, including KH alone, metformin alone, clomiphene alone, KH combined with metformin, and KH combined with clomiphene. The physicochemical characteristics of the honey were assessed using several tests, and its semi-volatile organic compounds were determined via gas chromatography-mass spectrometry.
KH and its combinations with either metformin or clomiphene were found to improve the hormonal profile and ease oxidative stress in the rats. However, while the treatments seemed to improve the oestrus cycle, they reportedly did not affect fasting blood glucose, insulin levels, or body weight in the test subjects.
PCOS patients suggests that combining acupuncture with metformin might enhance pregnancy and ovulation rates, as well as improve insulin resistance.
2022 Frontiers in Endocrinology Acupuncture combined with metformin versus metformin alone to improve pregnancy rate in polycystic ovary syndrome: A systematic review and meta-analysis Chen X, Lan Y, Yang L, Liu Y, Li H, Zhu X, et al.
Systematic Review Pregnancy
The study initially screened 330 relevant articles, eventually including nine randomized controlled trials (RCTs) that met the inclusion criteria. These trials encompassed 1,159 patients with PCOS who underwent acupuncture or acupuncture combined with metformin treatment. Using the GRADE method, a "Summary of Findings" table was employed to evaluate the quality of evidence for various outcome measures. The main results indicated that acupuncture combined with metformin exhibited superiority over metformin alone in terms of pregnancy rate, ovulation rate, and HOMA-IR (insulin resistance). Subgroup analysis highlighted that diagnostic criteria and random methods contributed to heterogeneity in results.
However, the evidence's quality was predominantly low or very low due to study limitations, inconsistencies, and imprecisions. The intervention measures, such as acupuncture methods and treatment parameters, varied substantially among studies. Challenges in contacting original authors and incomplete information posed further limitations. The study suggested potential improvements in pregnancy rate, ovulation rate, and HOMA-IR with acupuncture combined with metformin, but these findings were subject to uncertainties related to diagnostic criteria and overall evidence quality. Consequently, the conclusive efficacy of acupuncture combined with metformin for treating PCOS remains uncertain due to the dearth of high-quality research. The study called for well-designed and well-executed RCTs to address this question under standardized diagnostic criteria and treatment protocols for acupuncture and metformin.
Chinese herbal medicine combined with moxibustion might be beneficial for treating PCOS, and the treatment might improve the therapeutic effects of conventional western medications including clomiphene citrate, oral contraceptives, and/or metformin.
2018 Medicine Oriental herbal medicine and moxibustion for polycystic ovary syndrome Kwon, Chan-Young, Lee, Boram, Park, Kyoung Sun
Systematic Review Chinese Herbal Medicine Moxibustion
According to current evidence, oriental herbal medicine combined with moxibustion might be beneficial for treating PCOS. Moreover, the treatment might improve the therapeutic effects of conventional WMs including clomiphene citrate, OCPs, and/or metformin. However, the findings should be interpreted with great caution, owing to poor methodological quality of the included studies, especially the high risks of selection bias, performance bias, and detection bias. Further larger, high-quality, rigorous RCTs should be conducted in this regard.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Acupuncture combined with metformin versus metformin alone to improve pregnancy rate in polycystic ovary syndrome: A systematic review and meta-analysis
2022 Aug 29 Frontiers in Endocrinology Chen X, Lan Y, Yang L, Liu Y, Li H, Zhu X, et al.
Systematic Review Meta-Analysis PregnancyPCOS patients suggests that combining acupuncture with metformin might enhance pregnancy and ovulation rates, as well as improve insulin resistance.
Oriental herbal medicine and moxibustion for polycystic ovary syndrome
2018 Oct Medicine Kwon, Chan-Young, Lee, Boram, Park, Kyoung Sun
Systematic Review Meta-Analysis Moxibustion Chinese Herbal MedicineChinese herbal medicine combined with moxibustion might be beneficial for treating PCOS, and the treatment might improve the therapeutic effects of conventional western medications including clomiphene citrate, oral contraceptives, and/or metformin.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial
2022 Nov 29 Frontiers in Nutrition Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, et al.
Randomised Controlled Trial Cinnamon Testosterone Metabolic Syndrome FSH Ginger PCOS Insulin Resistance Metformin Ceylon Cinnamon LHIn women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones.
The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial
2019 Mar 11 Journal of Obstetrics and Gynaecology Mokaberinejad R, Rampisheh Z, Aliasl J, Akhtari E.
The present study concludes that fennel seed infusion plus a dry cupping therapy is effective and safe in reducing the days between two menstrual periods and manages oligomenorrhoea.
Randomised Controlled Trial PCOS CuppingEvaluation of Fenugreek (Trigonella foenum-graceum L.), Effects Seeds Extract on Insulin Resistance in Women with Polycystic Ovarian Syndrome
2013 Jan Iranian Journal of Pharmaceutical Research Hassanzadeh Bashtian M, Emami SA, Mousavifar N, Esmaily HA, Mahmoudi M, Mohammad Poor AH
Adjuvant therapy to the fenugreek seeds extract (with metformin) in PCOS women improved the sonographic results and menstrual cyclicity.
Randomised Controlled Trial FenugreekStudy Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Randomised Controlled Trial
In women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones.
Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, Mohammadi-Sartang M, Wong A, Babajafari S, Mazloomi SM
Network Pharmacology
Kelulut honey, either alone or in combination with metformin or clomiphene, can alleviate oxidative stress and reproductive and metabolic abnormalities in rats with polycystic ovary syndrome.
Kamal DAM, Ibrahim SF, Ugusman A, Mokhtar MH
Systematic Review
PCOS patients suggests that combining acupuncture with metformin might enhance pregnancy and ovulation rates, as well as improve insulin resistance.
Chen X, Lan Y, Yang L, Liu Y, Li H, Zhu X, Zhao Y, Long C, Wang M, Xie Q, Li Z, Wu J
Systematic Review
Chinese herbal medicine combined with moxibustion might be beneficial for treating PCOS, and the treatment might improve the therapeutic effects of conventional western medications including clomiphene citrate, oral contraceptives, and/or metformin.
Kwon, Chan-Young, Lee, Boram, Park, Kyoung Sun
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Metformin" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Metformin" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Metformin" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Randomised Controlled Trial published in 2022 in the journal Frontiers in Nutrition found that In women with polycystic ovary syndrome, cinnamon reduced insulin resistance and testosterone levels similar to metformin, and ginger decreased follicle-stimulating and luteinizing hormones. In the methodology of the study, 100 women diagnosed with polycystic ovary syndrome were divided into four groups. Each group received a different treatment: cinnamon, ginger, metformin, or placebo. The dosage for these treatments was 500 mg, three times a day, administered over a period of 8 weeks. The participants' sex hormones, weight revelations, along with glycemic and lipid markers were monitored before and after this period. Several participants were disqualified because of unspecified factors, resulting in a final sample size of 83. In terms of results, all groups saw a decrease in weight and body mass index. The metformin and cinnamon groups specifically had notably decreases in their insulin resistance, meaning that these treatments were effective in improving metabolic health. Additionally, the ginger group experienced a reduction in follicle-stimulating hormone and luteinizing hormone levels unlike the other groups. Testosterone levels were lowered in the metformin and cinnamon groups, but no significant changes in dehydroepiandrosterone were observed in any of the groups. These results indicate the potential use of cinnamon and ginger as alternative treatments in managing polycystic ovary syndrome.
A Network Pharmacology published in 2022 in the journal Antioxidants found that Kelulut honey, either alone or in combination with metformin or clomiphene, can alleviate oxidative stress and reproductive and metabolic abnormalities in rats with polycystic ovary syndrome. To examine the effects of Kelulut honey (KH), metformin, and clomiphene on polycystic ovary syndrome (PCOS), female Sprague-Dawley rats were treated with letrozole to stimulate symptoms of PCOS. The rats were then split up into six groups, each group undergoing a different kind of treatment for a period of 35 days, including KH alone, metformin alone, clomiphene alone, KH combined with metformin, and KH combined with clomiphene. The physicochemical characteristics of the honey were assessed using several tests, and its semi-volatile organic compounds were determined via gas chromatography-mass spectrometry. KH and its combinations with either metformin or clomiphene were found to improve the hormonal profile and ease oxidative stress in the rats. However, while the treatments seemed to improve the oestrus cycle, they reportedly did not affect fasting blood glucose, insulin levels, or body weight in the test subjects.
A Systematic Review published in 2022 in the journal Frontiers in Endocrinology found that PCOS patients suggests that combining acupuncture with metformin might enhance pregnancy and ovulation rates, as well as improve insulin resistance. The study initially screened 330 relevant articles, eventually including nine randomized controlled trials (RCTs) that met the inclusion criteria. These trials encompassed 1,159 patients with PCOS who underwent acupuncture or acupuncture combined with metformin treatment. Using the GRADE method, a "Summary of Findings" table was employed to evaluate the quality of evidence for various outcome measures. The main results indicated that acupuncture combined with metformin exhibited superiority over metformin alone in terms of pregnancy rate, ovulation rate, and HOMA-IR (insulin resistance). Subgroup analysis highlighted that diagnostic criteria and random methods contributed to heterogeneity in results. However, the evidence's quality was predominantly low or very low due to study limitations, inconsistencies, and imprecisions. The intervention measures, such as acupuncture methods and treatment parameters, varied substantially among studies. Challenges in contacting original authors and incomplete information posed further limitations. The study suggested potential improvements in pregnancy rate, ovulation rate, and HOMA-IR with acupuncture combined with metformin, but these findings were subject to uncertainties related to diagnostic criteria and overall evidence quality. Consequently, the conclusive efficacy of acupuncture combined with metformin for treating PCOS remains uncertain due to the dearth of high-quality research. The study called for well-designed and well-executed RCTs to address this question under standardized diagnostic criteria and treatment protocols for acupuncture and metformin.
A Systematic Review published in 2018 in the journal Medicine found that Chinese herbal medicine combined with moxibustion might be beneficial for treating PCOS, and the treatment might improve the therapeutic effects of conventional western medications including clomiphene citrate, oral contraceptives, and/or metformin. According to current evidence, oriental herbal medicine combined with moxibustion might be beneficial for treating PCOS. Moreover, the treatment might improve the therapeutic effects of conventional WMs including clomiphene citrate, OCPs, and/or metformin. However, the findings should be interpreted with great caution, owing to poor methodological quality of the included studies, especially the high risks of selection bias, performance bias, and detection bias. Further larger, high-quality, rigorous RCTs should be conducted in this regard.
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