Research insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
2023 F&S Science
Network Pharmacology EGCG Uterine Fibroids
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Chinese Medicine Research Hub
Network Pharmacology
Combining Crila with green tea extract (EGCG) has been found to synergistically hinder the growth of human uterine fibroid cells.
2023 F&S Science The combination of natural compounds Crila and epigallocatechin gallate (EGCG) showed enhanced antiproliferative effects on human uterine fibroid cells compared to single treatments.
Bai T, Ali M, Somers B, Yang Q, McKinney S, Al-Hendy A
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Crila" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Crila" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Crila" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Network Pharmacology published in 2023 in the journal F&S Science found that Combining Crila with green tea extract (EGCG) has been found to synergistically hinder the growth of human uterine fibroid cells. In the methodological process, human uterine leiomyoma (HuLM) cells were treated with varying concentrations of Crila, either alone or combined with epigallocatechin gallate (EGCG), employing various tests. Prominently, assays were performed to examine cell proliferation, with additional analyses conducted to measure protein and gene expressions of proliferation markers.
The interaction of Crila and EGCG resulted in a notable reduction in HuLM cell viability, showing an increased inhibitory effect over singular treatments. This decrease in cell proliferation is attributed to a synergistic efficacy derived from using Crila and EGCG in combination. It was notably characterised by the reduced presence of the proliferation marker, proliferating cell nuclear antigen, both at the messenger RNA and protein levels. It was observed that the process does not induce cell apoptosis, implying that the cell viability reduction is primarily due to decreased cell proliferation.
